Arbovirus Prediction and Mitigation in the Indo-Pacific

印度-太平洋地区的虫媒病毒预测和缓解

• 批准号: 10429130
• 负责人: Joelle Ivy Rosser
• 金额: $ 19.33万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10429130
• 关键词: 5 year old; Address; Aedes; Arbovirus Infections; Arboviruses; Blood Circulation; Blood specimen; Breeding; Chikungunya fever; Child; Climate; Collection; Communicable Diseases; Communities; Country; Culicidae; Custom; Data; Dengue; Dengue Fever; Dengue Infection; Development Plans; Diagnostic; Disease; Disease Outbreaks; Drainage procedure; Droughts; Emerging Communicable Diseases; Enrollment; Environment; Environmental Risk Factor; Enzyme-Linked Immunosorbent Assay; Epidemiology; Evaluation; Exposure to; Fiji; Floods; Foundations; Future; Goals; Habitats; Hot Spot; Household; Image; Immunoglobulin G; Incidence; Indonesia; Infection; Infectious Disease Epidemiology; Infrastructure; Insecticides; Interdisciplinary Study; Intervention; Island; Knowledge; Laboratories; Life; Life Cycle Stages; Light; Measures; Mentorship; Modeling; Modification; Nested Case-Control Study; Pacific Islands; Pathway interactions; Pattern; Physicians; Randomized Controlled Trials; Research; Resistance; Risk; Risk Factors; Running; Serology test; Site; Slum; Source; Surveillance Modeling; Surveys; System; Testing; Training; Tropical Medicine; Vaccines; Water; World Health Organization; Yellow fever virus; ZIKA; Zika Virus; base; career; career development; chikungunya; chikungunya infection; climate change; climate data; cost; design; disease transmission; experience; global health; high risk; infection rate; infectious disease model; innovation; mathematical model; novel; predictive modeling; programs; prototype; seropositive; transmission process; vector control; water environment; zika fever

Project Summary / Abstract Dengue, a potentially life-threatening disease, has increased 30-fold in the last 50 years. In Indonesia, 1 in 3 children have had a dengue infection by 5 years old. Islands in the Indo-Pacific are highly vulnerable to climate change and water insecurity, two key drivers of arbovirus spread. Predicting and mitigating arbovirus transmission in the Indo-Pacific is critical to addressing the increasing risk of arboviruses in the U.S. In the next several decades, half the U.S. may have habitat suitable for Aedes aegypti and Ae. albopictus, mosquitos which spread dengue, chikungunya, Zika, and yellow fever viruses. Revitalizing Informal Settlements and their Environments (RISE) is a cluster randomized control trial evaluating the benefits of upgrading local water infrastructure in urban slums in Indonesia and Fiji. The RISE intervention is a prototype for future slum upgrading to address climate change and water insecurity throughout the Indo- Pacific. Although the World Health Organization recommends permanent environmental modification as an arbovirus control strategy, this has never before been rigorously tested. RISE provides an important opportunity to evaluate whether this model decreases or inadvertently increases arbovirus transmission. In addition to evaluating a new paradigm for mitigating arbovirus transmission, RISE is an ideal platform to assess gaps in knowledge about environmental drivers of arbovirus transmission. My hypothesis is that modifiable environmental conditions drive arbovirus transmission in these communities. To test this hypothesis, I will leverage the RISE platform to study arbovirus risk factors in this region and evaluate the impact of permanent environmental modification on arbovirus transmission in urban slums. I will also create a mathematical model to simulate arbovirus transmission in this region under a range of climate change and intervention scenarios. I have developed a customized career development plan that aligns with my proposed research. It incorporates both formal and informal training under the mentorship of Drs. LaBeaud and Luby. This training plan draws upon my existing expertise in global health, tropical medicine, and epidemiology; it will enhance my expertise in laboratory diagnostics, geospatial analysis, and mathematical modeling. The planned didactics and technical training included here will provide the foundation necessary to achieve my goal of becoming an academic physician focused on mitigating the spread of infectious diseases in the era of climate change.

项目摘要 /摘要 登革热是一种潜在的威胁生命的疾病，在过去的50年中增加了30倍。在印度尼西亚，三分之一 儿童在5岁时感染了登革热。印度太平洋的岛屿非常容易受到气候 变化和水不安全感，arbovirus的两个关键驱动因素扩散。预测和缓解arbovirus 印度太平洋地区的传播对于解决下一个美国的丁香病毒风险增加至关重要 几十年来，美国一半的栖息地适合埃及埃及和AE。蚊子的白化病 传播登革热，基孔肯雅，寨卡病毒和黄热病病毒。 振兴非正式定居点及其环境（RISE）是一项群集随机对照试验评估 升级印度尼西亚和斐济城市贫民窟的当地水基础设施的好处。上升干预 是未来贫民窟升级的原型，以解决整个印度的气候变化和水不安全感 太平洋。尽管世界卫生组织建议永久性环境修改作为 Arbovirus控制策略，这从未经过严格测试。上升提供了重要的 评估该模型是否会减少还是无意间增加Arbovirus的传播的机会。 除了评估用于缓解Arbovirus传播的新范式外，Rise还成为理想的平台 评估有关Arbovirus传播环境驱动因素的知识的差距。我的假设是 可修改的环境条件驱动这些社区中的Arbovirus传播。为了检验这一假设， 我将利用Rise平台来研究该地区的Arbovirus风险因素，并评估 在城市贫民窟中的Arbovirus传播的永久环境修饰。我还将创建一个 在气候变化范围内模拟该区域中arbovirus传播的数学模型 干预方案。 我已经制定了一项定制的职业发展计划，该计划与我的拟议研究保持一致。它合并 在DRS的指导下，正式和非正式培训。 Labeaud和Lu​​by。该培训计划得出 根据我在全球健康，热带医学和流行病学方面的现有专业知识；它将增强我的专业知识 在实验室诊断，地理空间分析和数学建模中。计划中的教学和技术 这里包括的培训将为实现成为学术的目标提供必要的基础 医生的重点是减轻气候变化时代传染病的传播。