Research Development Core

研究开发核心

• 批准号: 10425455
• 负责人: Ronny Korstanje
• 金额: $ 20.67万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10425455
• 关键词: Affect; Aging; Applications Grants; Award; Biological; Biological Models; Biology of Aging; Budgets; Cells; Collaborations; Communities; Data; Disease; Environment; Faculty; Foundations; Funding; Funding Agency; Genes; Genetic; Geroscience; Goals; Grant; Institution; Laboratories; Lead; Longevity; Mentorship; Molecular; Mus; Pathway interactions; Phenotype; Play; Process; Publications; Research; Research Personnel; Resources; Role; Scientist; Shock; Systems Biology; Talents; Technology; The Jackson Laboratory; Tissues; Work; Writing; age related; biological systems; body system; career; career development; cohort; design; experimental study; healthy aging; innovation; insight; meetings; mouse genetics; programs; research and development; success

RESEARCH DEVELOPMENT CORE PROJECT SUMMARY Understanding the complexity of the aging process and its profound effects across all levels of biological organization will require a strong, interdisciplinary, and diverse supply of talented scientists. The overall goal of The Jackson Laboratory Nathan Shock Center (JAX NSC) Research Development Core is to provide support for career development of junior faculty entering the field of basic aging biology or other investigators who wish to change career direction towards basic aging research. In 2017, the pilot award format was changed from providing funds awarded to two investigators per year ($50,000 each) to an innovative in-kind program where experiments were streamlined for awardees enabling more experiments to be performed for a larger number of investigators within the same budget. During the current funding period, the JAX NSC Research Development Core competitively awarded funding and resources to aging projects across biological systems that resulted in new discoveries, research publications and sources of funding, and helped junior awardees to establish their own independent careers in aging research. Moving forward, these successes will be expanded by providing targeted funding to exciting projects proposed by investigators new to aging research, and by offering a variety of research and intellectual resources to support awardees and other aging investigators in their work. The outstanding institutional resources available at JAX, a premier institution for mouse genetics and systems biology research, will be leveraged to sustain and grow this foundation of researchers at JAX and within the aging community. The Specific Aims are: Aim 1. Fund projects for new investigators in aging research using a competitive pilot award program. Promising investigators new to aging research will be funded through a competitive process so they can generate the data and gain the expertise necessary to support competitive funding applications and a transition to a career in aging biology. Aim 2. Provide resources to support pilot awardees and investigators new to aging research. Access to resources (e.g., aging mice, data, tissues, phenotype platforms, expertise) will be provided to support pilot awardees and other investigators new to aging research. The aging mouse cohorts and phenotyping technologies supported by the JAX NSC present a valuable opportunity for investigators to access material and collect data that might otherwise be prohibitively expensive or difficult to obtain. Aim 3. Provide mentorship and career development opportunities in aging research. Investigators new to aging research will be provided with mentorship by JAX NSC researchers and collaborators. They will also be given opportunities for career development in the aging field via support with the grant writing process, opportunities to participate in aging meetings, and introductions to potential collaborations within the broader aging community. The impact of the Research Development Core is that the pool of investigators devoted to the study of the basic biology of aging will be expanded.

研究开发核心 项目摘要 了解衰老过程的复杂性及其在所有级别的生物学上的深刻影响 组织将需要强大，跨学科和多样化的才华横溢的科学家。总体目标 杰克逊实验室内森冲击中心（JAX NSC）研究开发核心是提供支持 为了进入初级教师的职业发展，进入基本老化生物学领域或其他希望 改变职业方向向基本的衰老研究。在2017年，试点奖的格式从 每年向两名调查人员提供资金（每个50,000美元） 简化了实验，以使获奖者能够进行更多的实验 在相同预算的调查人员。在当前的资金期间，JAX NSC研究开发 核心竞争性地向跨生物系统的衰老项目授予资金和资源，导致 新发现，研究出版物和资金来源，并帮助初级获奖者建立了他们的 自己在衰老研究中的独立职业。展望未来，这些成功将通过提供 针对新手研究的调查人员提出的令人兴奋的项目的有针对性资金，并提供了一种多样性 研究和智力资源以支持获奖者和其他老龄化研究者的工作。这 Jax的杰出机构资源可在鼠标遗传学和系统生物学的主要机构中获得 研究将被利用以维持和发展JAX和衰老的研究人员的基础 社区。具体目的是：AIM 1。使用A的新调查人员资助项目 竞争性飞行员奖计划。新手衰老研究的有前途的调查人员将通过 竞争过程，以便他们可以生成数据并获得支持竞争性必要的专业知识 资金应用程序和向衰老生物学事业的过渡。目标2。提供支持飞行员的资源 获奖者和调查人员迈向衰老研究。获取资源（例如，老化的小鼠，数据，组织， 将提供表型平台，专业知识），以支持试验者和其他熟悉的调查员 研究。 JAX NSC支持的老鼠队列和表型技术提出了有价值的 调查人员的机会访问材料和收集可能过高的数据的材料和收集数据 或难以获得。 AIM 3。提供老龄化研究的指导和职业发展机会。 JAX NSC的研究人员和合作者将提供熟悉衰老研究的研究人员。 他们还将通过赠款写作的支持，为他们提供衰老领域的职业发展的机会 过程，参加衰老会议的机会以及对潜在合作的介绍 更广泛的衰老社区。研究开发核心的影响是研究人员库 致力于研究衰老基本生物学的研究。