FASEB SRC on The Biology of Cilia and Flagella

FASEB SRC 关于纤毛和鞭毛的生物学

• 批准号: 10426069
• 负责人: REBECCA D. BURDINE
• 金额: --
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426069
• 关键词: Academia; Adolescent; Affect; Appetitive Behavior; Area; Basal cell carcinoma; Basic Science; Biological Process; Biology; Blindness; Brain Neoplasms; Cell surface; Cells; Child; Cilia; Clinical Sciences; Collaborations; Congenital Heart Defects; Data; Defect; Development; Diabetes Mellitus; Disease; Educational process of instructing; Educational workshop; Embryonic Development; Ensure; Environment; Fees; Flagella; Focus Groups; Fostering; Foundations; Functional disorder; Funding; Future; G-Protein-Coupled Receptors; Genetic; Goals; Growth; Health; Hospitals; Human; Human Development; Idiopathic scoliosis; Image; Impairment; Industry; Inherited; International; Jeune syndrome; Joubert syndrome; Kidney Diseases; Lead; Leber' s amaurosis; Life Cycle Stages; Light; Link; Male Infertility; Malignant Neoplasms; Methods; Modeling; Molecular; Nephronophthisis; Obesity; Odors; Oral; Organ; Organelles; Parasites; Physicians; Play; Polycystic Kidney Diseases; Polydactyly; Postdoctoral Fellow; Proteins; Publications; Publishing; Research; Research Personnel; Respiratory Tract Infections; Role; Schedule; Science; Scientist; Sensory; Signal Pathway; Signal Transduction; Structural Protein; Syndrome; Techniques; Time; Tissues; Training; Translating; Travel; Trypanosoma; Underrepresented Minority; Virulence; Vision; Woman; base; bone; career; career development; cell motility; ciliopathy; college; developmental disease; genome-wide; human disease; innovation; interest; malformation; medulloblastoma; meeting abstracts; meetings; member; neglect; novel; posters; rapid growth; receptor; response; smoothened signaling pathway; summer research; symposium; trend

Abstract Cilia and flagella are thread-like cell organelles protruding from the cell surface into the environment. Long neglected, research on the biology of cilia has seen tremendous growth over the last two decades as their central role in cellular sensing and human disease emerged. Defective cilia cause multi-organ disorders such as Bardet-Biedl, Meckel Gruber, and Joubert syndrome. Cilia participate in several signaling pathways including vertebrate Hedgehog signaling, which is critical for embryonic development and has been implicated in certain cancers including basal cell carcinomas and medulloblastomas, the most common brain tumor in juveniles. G-protein coupled receptors have key roles in mammalian sensing and signaling and many of the receptors are located in cilia. Sensing of light and odors, for example, occurs in cilia and cilia-based receptors have been implicated in the control of appetite, behavior and vision. Thus, ciliary dysfunction contributes to common diseases such as blindness, diabetes and obesity. The purpose of this proposal is to support the participation of junior scientists studying cilia biology and cilia-related disease at the FASEB Summer Research Conferences on the Biology of Cilia and Flagella in 2019, 2021 and 2023. The FASEB conference on cilia and flagella is the premier international meeting on cilia signaling and cilia-related disease. The conference brings together cell, molecular, and developmental biologists, human geneticists, biochemists, physician scientists and biophysicists with interests ranging from the fundamental biology of cilia to the genetics and molecular mechanisms of human cilia-based diseases and their treatment options. In this proposal, we request funds to support junior scientists and investigators, who have not participated in this FASEB conference before, to attend as speakers to promote growth and innovation of the field. A Meet-the-Experts session will be held at the first day of the meeting to facilitate informal interaction between senior members of the field meet and junior scientists and newcomers. We will invite representatives from industry, foundations, teaching colleges and publishing to participate in three workshops on career development and options in and outside of academia. This international meeting is very well attended by postdocs and early stage investigators as well as established experts in the field. This mix of attendees will further the goal of the conference of generate research collaborations, identify key challenges in the field, and stimulate innovative research on the biology of cilia, cilia-related disease and therapies.

抽象的 纤毛和鞭毛是从细胞表面突出到细胞内的线状细胞器 环境。长期被忽视的纤毛生物学研究在过去几年中取得了巨大的发展 过去二十年，它们在细胞传感和人类疾病中的核心作用逐渐显现。 有缺陷的纤毛会导致多器官疾病，例如 Bardet-Biedl、Meckel Gruber 和 Joubert 综合症。纤毛参与多种信号通路，包括脊椎动物 Hedgehog 信号传导，对胚胎发育至关重要，并与某些癌症有关 包括基底细胞癌和髓母细胞瘤，这是最常见的脑肿瘤 青少年。 G 蛋白偶联受体在哺乳动物传感和信号传导中发挥关键作用 许多受体位于纤毛中。例如，光和气味的感知发生在纤毛中 基于纤毛的受体与食欲、行为和视力的控制有关。 因此，纤毛功能障碍会导致失明、糖尿病等常见疾病 肥胖。该提案的目的是支持年轻科学家参与研究 FASEB 夏季研究会议上的纤毛生物学和纤毛相关疾病 2019 年、2021 年和 2023 年纤毛和鞭毛生物学。 FASEB 关于纤毛和鞭毛的会议是关于纤毛的首要国际会议 信号传导和纤毛相关疾病。会议汇集了细胞、分子和 发育生物学家、人类遗传学家、生物化学家、医学科学家和生物物理学家 兴趣广泛，从纤毛的基础生物学到遗传学和分子生物学 人类纤毛疾病的机制及其治疗方案。在这个提案中，我们 请求资金支持未参与此项目的初级科学家和研究人员 在FASEB会议之前，作为演讲者出席以促进该领域的增长和创新。 会议第一天将举行专家会见会议，以促进非正式会议 现场会议的高级成员与初级科学家和新人之间的互动。我们 将邀请来自行业、基金会、师范学院和出版界的代表 参加三个关于学术界内外职业发展和选择的研讨会。 这次国际会议也有很多博士后和早期研究人员参加 作为该领域的知名专家。与会者的这种组合将进一步推动会议的目标 开展研究合作，确定该领域的关键挑战，并激发创新 纤毛生物学、纤毛相关疾病和治疗的研究。