Vascular Training Grant

血管培训补助金

• 批准号: 10421261
• 负责人: JEFFREY R. BENDER
• 金额: $ 58.25万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10421261
• 关键词: Blood Vessels; Grant; Training

This is the fourth competing renewal application for Yale University’s Vascular Research Postdoctoral T32. Of fellows who have completed training to date, 65% have obtained academic faculty positions and/or careers in science, and many have received independent grant support, strong indicators of program success. The continued goal is to provide laboratory and translational research training for highly qualified, diverse physician (M.D. and M.D./Ph.D.) and Ph.D. postdoctoral fellows in vascular biology, in preparation for careers as independent investigators in blood vessel biology- and medicine-related disciplines. Trainee selection will be based on a commitment to vascular biology and strong prior research experience or potential of same. Applications will be encouraged from clinical and basic science departments, with a nationwide competition for 7 yearly slots. Minority applicants will be specifically solicited through numerous avenues. 38% of the current funding cycle fellows are underrepresented minorities. The training will be mentor-based, also including advisory committees and didactic courses. The minimum duration of training will be 2 years. The Cardiovascular Medicine Division and Yale’s Interdisciplinary Program in Vascular Biology and Therapeutics will be the foundations for the program. A key asset is Yale’s interdisciplinary strength in vascular biology. Departmental affiliations for participating faculty include Cardiovascular Medicine, Immunobiology, Pharmacology, Pathology, Genetics, Bioengineering, Physiology, Cardiothoracic Surgery, and Computational Science. Faculty were chosen based on impressive histories of mentorship, ongoing vascular research productivity, strong extramural support and commitment to serve as mentors within the program. Examples of research opportunities include: (1) molecular determinants and consequences of leukocyte-endothelial cell interactions; (2) molecular imaging of angiogenesis and vascular remodeling utilizing nuclear and MR imaging in animal models; (3) mapping and identification of genes that contribute to the development of vascular disease (arterio-venous malformation, coronary artery disease) in humans; (4) engineering of vascular biomaterials; (5) generation of angiogenic gene regulators for use in clinical trials and (6) novel single cell RNA sequence analytic methods for determination of atherosclerosis-promoting cellular phenotypes. The last of these represents a top tier computational science component newly added to our program. This is a wide range of disease-related vascular research, with key translational components. Trainee progress will be monitored by each mentor, the trainee’s advisory committee and the Program Co-Directors. It is the expectation that we will train future national and international leaders in vascular research. Cardiovascular disease is the leading cause of death in the U.S., and a major cause of mortality world-wide. This program will provide important opportunities for diverse individuals from multiple disciplines to eventually lead high impact efforts at reducing the incidence of, and improving outcomes in, cardiovascular disease.

这是耶鲁大学血管研究博士后T32的第四次竞争续签申请。的 迄今已完成培训的研究员，有65％的人获得了学术教师职位和/或职业 科学，许多人都得到了独立的赠款支持，这是计划成功的有力指标。 持续的目标是为高素质，多样性的实物提供实验室和翻译的研究培训 （M.D.和M.D./ph.d。）和博士学位血管生物学的博士后研究员为职业做准备 血管生物学和医学相关学科的独立研究者。学员的选择将是 基于对血管生物学的承诺和强大的先前研究经验或潜力。 临床和基础科学部门将鼓励申请，并在全国范围内进行竞争 每年7个老虎机。少数民族申请人将通过许多途径进行特殊巩固。当前的38％ 资金周期研究员的人数不足。培训将基于心理，也包括 咨询委员会和教学课程。最低培训时间为2年。 心血管医学部和耶鲁大学血管生物学和治疗学方面的跨学科计划 将是该计划的基础。关键资产是耶鲁大学在血管生物学方面的跨学科力量。 参与教师的系分支机构包括心血管医学，免疫生物学， 药理学，病理学，遗传学，生物工程，生理学，心胸外科手术和计算 科学。根据令人印象深刻的心态，持续的血管研究选择教师 生产力，强大的壁外支持以及对该计划中的导师的承诺。示例的例子 研究机会包括：（1）分子确定剂和白细胞 - 内皮细胞的后果 互动； （2）使用核和MR成像的血管生成和血管重塑的分子成像 在动物模型中； （3）绘制和鉴定有助于血管发展的基因 人类疾病（动脉畸形，冠状动脉疾病）； （4）血管的工程 生物材料； （5）生成用于临床试验的血管生成基因调节剂和（6）新型的单细胞RNA 测定动脉粥样硬化的细胞表型的序列分析方法。最后一个 这些代表了新添加到我们计划中的顶级计算科学组件。这是一个宽阔的 与疾病相关的血管研究范围，具有关键的转化成分。学员的进步将是 受到每个心理，受训者的咨询委员会和计划联合指导的监视。是 期望我们将在血管研究中培训未来的国家和国际领导人。心血管 疾病是美国死亡的主要原因，也是全球死亡率的主要原因。这个程序将 为来自多个学科的潜水员提供重要的机会，以最终引起高影响力 减少心血管疾病的事件并改善结果的努力。