Immunology and Pathogenesis Program Training Grant

免疫学和发病机制计划培训补助金

基本信息

批准号：
10421298
负责人：
ELLEN A ROBEY
金额：
$ 39.82万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10421298
关键词：
Grant Immunology Pathogenesis Training Programs

项目摘要

This competing application for a training program in Immunology and Pathogenesis (IMP) supports the training activities of 15 field-leading scientists whose research centers on immunobiology. The training faculty are all members of the Department of Molecular and Cell Biology (MCB), and each has ample research support and a strong commitment to mentoring. The training program is centered in the MCB Division of Immunology and Pathogenesis, in which most training faculty are members. The IMP Training program focuses on basic immunological mechanisms in the context of infections, cancer and immunopathology. We are motivated by the shared belief that achieving a thorough, basic understanding of recognition, activation, regulation, differentiation and interactions of cells of the immune system will lead to therapies for infectious disease, cancer and other ailments, and that training young investigators in this approach, while providing broad training in basic molecular and cell biology, offers a most productive avenue for enhancing success in this endeavor. The program is strongly committed to recruiting and training students and postdocs from diverse personal backgrounds. The IMP training program will provide a home for trainees in Immunology and Pathogenesis and support for training related activities. We propose support for 4 graduate students and 3 postdoctoral fellows. Graduate students will generally be supported starting in their second year to ensure commitment to the research area and to provide additional information to evaluate their capability of providing exceptional contributions to the program. Postdoctoral trainees will generally be supported starting in their first or second year. In general trainees will be supported for 2 years on the training grant, with additional years supported from other sources. While this training grant is currently in its 5th year, the grant is the successor of an NCI-supported training grant (Molecular Immunology and Tumor Biology Training Program, T32 CA009179), which supported immunology research at Berkeley for 35 years.

这种竞争性应用于免疫学和发病机理的培训计划（IMP）支持15位现场领导科学家的培训活动，其研究中心免疫生物学。培训教师都是分子和细胞系的成员生物学（MCB），每个人都有充分的研究支持和对指导的坚定承诺。该培训计划以MCB免疫学和发病机理为中心，大多数培训教师是成员。 IMP培训计划的重点是基本感染，癌症和免疫病理学的背景下的免疫机制。我们是由共同的信念激励，即对识别，激活，调节，分化和免疫细胞的相互作用系统将导致有关传染病，癌症和其他疾病的疗法，并且在这种方法中培训年轻的调查人员，同时提供基本的广泛培训分子和细胞生物学，为增强成功的最有生产力的途径这项工作。该计划强烈致力于招募和培训学生，来自不同个人背景的博士后。 IMP培训计划将为免疫学和发病机理的受训者以及对培训相关活动的支持。我们为4名研究生和3名博士后研究员提供支持。研究生会通常从第二年开始支持，以确保对研究领域的承诺并提供其他信息来评估其提供卓越的能力对该计划的贡献。一般而言，博士后学员一开始会得到他们的支持第一年或第二年。在一般的学员中，将在培训补助金上支持2年其他来源支持的多年。虽然这笔培训赠款目前处于第五位一年，该赠款是NCI支持的培训赠款的继任者（分子免疫学和肿瘤生物学培训计划，T32 CA009179），该计划支持免疫研究伯克利35年。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

T cell self-reactivity during thymic development dictates the timing of positive selection.

DOI：
10.7554/elife.65435
发表时间：
2021-04-22
期刊：
eLife
影响因子：
7.7
作者：
Lutes LK;Steier Z;McIntyre LL;Pandey S;Kaminski J;Hoover AR;Ariotti S;Streets A;Yosef N;Robey EA
通讯作者：
Robey EA

Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes.

影响 CD8αα 上皮内淋巴细胞胸腺选择的因素。

DOI：
10.1038/s41385-020-0295-5
发表时间：
2021-01
期刊：
MUCOSAL IMMUNOLOGY
影响因子：
8
作者：
Kurd, Nadia S.;Hoover, Ashley;Yoon, Jaewon;Weist, Brian M.;Lutes, Lydia;Chan, Shiao Wei;Robey, Ellen A.
通讯作者：
Robey, Ellen A.

Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway