Basic Sciences Core

基础科学核心

基本信息

批准号：
10417089
负责人：
SANJAY B. MAGGIRWAR
金额：
$ 35.2万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10417089
关键词：
Acquired Immunodeficiency Syndrome Animal Model Antibodies Applications Grants Award Basic Science Binding Biological Assay Budgets Cells Clinical Investigator Collection Computer software Confocal Microscopy Consult Consultations DNA sequencing Data Department chair Development District of Columbia Drug Modelings Drug Screening Education and Outreach Equipment Event Flow Cytometry Fostering Functional Imaging Funding Genomics HIV Image Image Analysis Immunologics Immunology Immunology procedure Individual Institution Interdisciplinary Study Investments Jordan Laboratories Laboratory Scientists Laboratory Technicians Leadership Maintenance Mass Spectrum Analysis Mentors Methods Microbiology Mission Molecular Proteins Proteomics Protocols documentation Proxy RNA analysis Reagent Research Research Personnel Resources Scientist Senior Scientist Series Service provision Services Suggestion Surface Plasmon Resonance System Techniques Technology Tissues Training Training Programs Transmission Electron Microscopy Tropical Medicine Underrepresented Minority United States National Institutes of Health Universities Update Wages Washington Woman Work assay development base cost image reconstruction in silico innovation instrument investigator training microscopic imaging minority investigator molecular imaging new technology next generation sequencing novel outreach programs protein expression protein purification recruit research and development service providers single cell analysis single cell sequencing small molecule transcriptome sequencing translational scientist viral detection virology

项目摘要

BASIC SCIENCES CORE (CORE C) PROJECT SUMMARY Leveraging the collective scientific expertise and resources across the DC CFAR partner institutions, the Basic Sciences Core (BSC) will provide an array of high impact laboratory services and training to HIV investigators in Washington, DC. Under the leadership of NIH-funded senior scientists and with a cadre of DC CFAR- supported Core service providers, the BSC will provide essential virology, immunology, proteomics, imaging and next-generation sequencing services including single cell analysis that foster scientific discovery in HIV research. These services are aimed at assisting investigators to acquire preliminary data for grant applications; conduct funded research protocols; and foster linkages with the SWGs and clinical and translational investigators. For Specific Aim 1, the Core will provide high impact laboratory services to CFAR investigators which will be evaluated routinely and updated or augmented based on user needs, advances in scientific research or the development of new technologies. For Specific Aim 2, the Core will provide training through individual-level technical support and larger CFAR-wide events. These include the hands-on Core service laboratory “open house” series and the annual Core Service Providers Research Day. The Core leadership will also collaborate with the Developmental Core to provide mentoring to basic science investigators; encourage submissions for pilot and transitioning investigator awards and microgrants; and strengthen multi-disciplinary research efforts. Lastly, consistent with the overall mission of the DC CFAR, the Core will focus on outreach to women and underrepresented minority investigators to assist their development as independent HIV laboratory scientists.

基础科学核心（核心 C）项目概要利用 DC CFAR 合作伙伴机构的集体科学专业知识和资源，基本科学核心 (BSC) 将为艾滋病毒研究人员提供一系列高影响力的实验室服务和培训在 NIH 资助的资深科学家和 DC CFAR 的骨干人员的领导下。支持核心服务提供商，平衡计分卡将提供必要的病毒学、免疫学、蛋白质组学、成像以及下一代测序服务，包括促进艾滋病毒科学发现的单细胞分析这些服务旨在协助研究人员获取拨款申请的初步数据；开展资助的研究方案；并促进与 SWG 以及临床和转化的联系对于具体目标 1，核心将为 CFAR 调查人员提供高影响力的实验室服务。将定期对其进行评估，并根据用户需求、科学进步进行更新或增强对于具体目标 2，核心将通过以下方式提供培训。个人级别的技术支持和更大的 CFAR 范围内的活动，其中包括实践核心服务。实验室“开放日”系列和年度核心服务提供商研究日。还与发展核心合作，为基础科学研究人员提供指导，鼓励；提交试点和过渡研究者奖励和小额赠款；并加强多学科合作；最后，与 DC CFAR 的总体工作一致，核心将重点关注外展活动妇女和代表性不足的少数族裔调查员协助他们发展成为独立的艾滋病毒实验室科学家。