Basic Sciences Core

基础科学核心

基本信息

批准号：
10417089
负责人：
SANJAY B. MAGGIRWAR
金额：
$ 35.2万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10417089
关键词：
Acquired Immunodeficiency Syndrome Animal Model Antibodies Applications Grants Award Basic Science Binding Biological Assay Budgets Cells Clinical Investigator Collection Computer software Confocal Microscopy Consult Consultations DNA sequencing Data Department chair Development District of Columbia Drug Modelings Drug Screening Education and Outreach Equipment Event Flow Cytometry Fostering Functional Imaging Funding Genomics HIV Image Image Analysis Immunologics Immunology Immunology procedure Individual Institution Interdisciplinary Study Investments Jordan Laboratories Laboratory Scientists Laboratory Technicians Leadership Maintenance Mass Spectrum Analysis Mentors Methods Microbiology Mission Molecular Proteins Proteomics Protocols documentation Proxy RNA analysis Reagent Research Research Personnel Resources Scientist Senior Scientist Series Service provision Services Suggestion Surface Plasmon Resonance System Techniques Technology Tissues Training Training Programs Transmission Electron Microscopy Tropical Medicine Underrepresented Minority United States National Institutes of Health Universities Update Wages Washington Woman Work assay development base cost image reconstruction in silico innovation instrument investigator training microscopic imaging minority investigator molecular imaging new technology next generation sequencing novel outreach programs protein expression protein purification recruit research and development service providers single cell analysis single cell sequencing small molecule transcriptome sequencing translational scientist viral detection virology

项目摘要

BASIC SCIENCES CORE (CORE C) PROJECT SUMMARY Leveraging the collective scientific expertise and resources across the DC CFAR partner institutions, the Basic Sciences Core (BSC) will provide an array of high impact laboratory services and training to HIV investigators in Washington, DC. Under the leadership of NIH-funded senior scientists and with a cadre of DC CFAR- supported Core service providers, the BSC will provide essential virology, immunology, proteomics, imaging and next-generation sequencing services including single cell analysis that foster scientific discovery in HIV research. These services are aimed at assisting investigators to acquire preliminary data for grant applications; conduct funded research protocols; and foster linkages with the SWGs and clinical and translational investigators. For Specific Aim 1, the Core will provide high impact laboratory services to CFAR investigators which will be evaluated routinely and updated or augmented based on user needs, advances in scientific research or the development of new technologies. For Specific Aim 2, the Core will provide training through individual-level technical support and larger CFAR-wide events. These include the hands-on Core service laboratory “open house” series and the annual Core Service Providers Research Day. The Core leadership will also collaborate with the Developmental Core to provide mentoring to basic science investigators; encourage submissions for pilot and transitioning investigator awards and microgrants; and strengthen multi-disciplinary research efforts. Lastly, consistent with the overall mission of the DC CFAR, the Core will focus on outreach to women and underrepresented minority investigators to assist their development as independent HIV laboratory scientists.

基本科学核心（核心C）项目摘要利用DC CFAR合作伙伴机构的集体科学专业知识和资源，这是基本的科学核心（BSC）将向艾滋病毒调查人员提供一系列高影响力实验室服务和培训在华盛顿特区。在NIH资助的高级科学家的领导下，并拥有DC CFAR的干部支持的核心服务提供商，BSC将提供必需的病毒学，免疫学，蛋白质组学，成像以及下一代测序服务，包括促进艾滋病毒科学发现的单细胞分析研究。这些服务旨在协助调查人员获取赠款申请的初步数据；进行资助的研究方案；并建立与SWG的联系以及临床和翻译调查人员。对于特定目标1，核心将为CFAR调查人员提供高影响力实验室服务它将根据用户需求进行定期评估，更新或增强，科学的进步研究或新技术的发展。对于特定目标2，核心将通过个人水平的技术支持和更大的CFAR范围活动。这些包括动手核心服务实验室“开放日”系列和年度核心服务提供商研究日。核心领导将还与发展核心合作，为基础科学研究者提供心理；鼓励试点和过渡调查员奖和微电磁的提交；并加强多学科研究工作。最后，与DC CFAR的整体任务一致，核心将重点放在外展上妇女和代表性不足的少数群体调查员以独立艾滋病毒实验室的发展协助其发展科学家。