Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education

培养转化糖生物学家：糖科学培训与临床教育的结合

• 批准号: 10418674
• 负责人: RICHARD D CUMMINGS
• 金额: $ 95.85万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10418674
• 关键词: Address; Appointment; Blood; Boston; Clinical; Clinical Medicine; Dana-Farber Cancer Institute; Development; Disease; Education; Educational workshop; Ensure; Faculty; Funding; General Hospitals; Glycobiology; Goals; Growth; Heart Diseases; Hospitals; Human Biology; Individual; Instruction; Israel; Knowledge; Laboratories; Lung; Massachusetts; Medical; Medical center; Mentors; NCI Scholars Program; Pediatric Hospitals; Postdoctoral Fellow; Principal Investigator; Program Development; Research; Research Personnel; Resources; Scientist; Sleep; Teaching Hospitals; Technical Expertise; Training; Translational Research; Universities; Woman; base; career; career development; clinical care; design; experience; forging; human disease; medical schools; multidisciplinary; programs; skills

ABSTRACT Currently there are very few individuals that can place clinical medicine within the framework of glycoscience, and vice versa. The key to bridging this translational chasm is to support the development of scientists with requisite interdisciplinary knowledge and experience by providing training in glycosciences concomitantly with education in human biology, altogether framed by an appreciation of human diseases and clinical urgency. This application addresses this need by pioneering a multi-disciplinary career development program in glycosciences within the context of clinical medicine that will create a cadre of “Translational Glycobiologists,” individuals who will perform glycoscience-based inquiry inspired by medical necessity. Fundamentally, this goal will be accomplished by equipping Program Scholars with the requisite intellectual background and the necessary lab skills in the glycosciences, together with an in-depth appreciation of clinical issues. To this end, we will build partnerships between experienced glycoscience researchers and clinicians within the Harvard teaching hospitals to nurture Program Scholar training in glycoscience principles and technical skills integrated with clinical knowledge and practice. The combination of Principal Investigators dedicated to this goal (Drs. Sackstein, Chaikof, and Cummings), together with the assembled faculty and the extraordinary hospital resources, makes this program ideal for career development in Translational Glycobiology. By design, the program capitalizes on the long tradition of translational research within the Brigham & Women’s Hospital, the Beth Israel Deaconess Medical Center, the Massachusetts General Hospital, the Boston Children’s Hospital, and the Dana-Farber Cancer Institute, as well as within the greater Harvard Medical School and Harvard University. Through coursework and seminars, Program Scholars will gain glycoscience knowledge with concomitant development of technical knowledge and skills in both primary laboratory settings and workshops. To ensure development across both scientific and clinical spectrums, each Program Scholar will be jointly mentored by a Research Mentor for lab-based project-oriented glycoscientific training and a Clinical Mentor for hospital-based clinical education. In addition, each Program Scholar will have a dedicated Career Mentor that will further support the Scholar transition towards career independence. Scholar appointments will be for two years (maximum three years), and we anticipate a total of ten Scholars over the duration of the funding period, with four Scholars being junior faculty clinicians and six Scholars being senior post-doctoral fellows. We believe that this unique combination of glycoscience education, laboratory instruction, clinical exposures, and mentoring will launch a cadre of biomedical investigators that will accelerate the growth of glycoscience, and, more importantly, will create needed glycoscience-based breakthroughs that will transform clinical care for disorders of heart, lung, blood, and sleep, and for many, many other diseases.

抽象的 目前，很少有人可以将临床医学放在糖科学框架内， 反之亦然。桥接这种翻译鸿沟的关键是支持科学家的发展 必要的跨学科知识和经验，通过与糖基镜同时提供培训 人类生物学的教育，完全由对人类疾病和临床紧迫性的欣赏。 该申请通过开创了一项多学科职业发展计划，以解决这一需求 在临床医学背景下的糖基镜会创建“转化糖生物学家”的干部， 受到必要医疗启发的基于糖科学的调查的个人。从根本上讲，这 目标将通过为计划学者提供必要的智力背景和 糖基镜的必要实验室技能，以及对临床问题的深入欣赏。对此 最后，我们将在经验丰富的聚​​糖研究人员和临床医生之间建立伙伴关系 哈佛教学医院为护士计划学者培训血糖原理和技术技能 与临床知识和实践融为一体。专门为此的主要研究人员的结合 目标（Sackstein博士，Chaikof和Cummings）以及组装的教师和非凡的 医院资源使该计划非常适合转化糖生物学的职业发展。经过 设计，该计划利用了杨百翰和妇女中翻译研究的悠久传统 医院，贝丝以色列女执事医疗中心，马萨诸塞州综合医院，波士顿 儿童医院和达纳 - 法伯癌症研究所以及大哈佛大学 学校和哈佛大学。通过课程和半少数，计划学者将获得糖科学 与在两个主要实验室环境中伴随的技术知识和技能的发展知识 和讲习班。为了确保科学和临床光谱之间的发展，每个计划学者 将由研究导师共同修复基于实验室的面向项目的糖科学培训和 基于医院的临床教育的临床导师。此外，每个课程学者都将有一个专门的 职业导师将进一步支持学者向职业独立性过渡。学者 约会将持续两年（最多三年），我们预计 资金期限的持续时间，四个学者是初级临床医生，六位学者是高级 博士后研究员。我们认为，聚糖教育，实验室的独特组合 指导，临床暴露和心理，将启动一群生物医学研究人员 加速糖基科学的生长，更重要的是，将创建基于糖基的所需 突破将改变心脏，肺，血液和睡眠障碍的临床护理，以及许多人的突破 许多其他疾病。

项目成果

Plasmodium knowlesi (Pk) Malaria: A Review & Proposal of Therapeutically Rational Exchange (T-REX) of Pk-Resistant Red Blood Cells.

• DOI: 10.3390/tropicalmed8100478
• 发表时间: 2023-10-20
• 期刊: Tropical medicine and infectious disease
• 影响因子: 2.9
• 作者: Jajosky RP;Wu SC;Jajosky PG;Stowell SR
• 通讯作者: Stowell SR

The impact of ABO and RhD blood types on Babesia microti infection.

• DOI: 10.1371/journal.pntd.0011060
• 发表时间: 2023-01
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8

Hypoxia Controls the Glycome Signature and Galectin-8-Ligand Axis to Promote Protumorigenic Properties of Metastatic Melanoma.

• DOI: 10.1016/j.jid.2022.07.033
• 发表时间: 2023-03
• 期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY
• 影响因子: 6.5
• 作者: Chakraborty, Asmi;Perez, Mariana;Carroll, Jordan D.;Antonopoulos, Aristotelis;Dell, Anne;Ortega, Liettel;Mohammed, Norhan B. B.;Wells, Michael;Staudinger, Caleb;Griswold, Anthony;Chandler, Kevin B.;Marrero, Cristina;Jimenez, Ramon;Tani, Yoshihiko;Wilmott, James S.;Thompson, John F.;Wang, Wei;Sackstein, Robert;Scolyer, Richard A.;Murphy, George F.;Haslam, Stuart M.;Dimitroff, Charles J.
• 通讯作者: Dimitroff, Charles J.

Multidimensional separation and analysis of alpha-1-acid glycoprotein N-glycopeptides using high-field asymmetric waveform ion mobility spectrometry (FAIMS) and nano-liquid chromatography tandem mass spectrometry.

使用高场不对称波形离子迁移谱 (FAIMS) 和纳米液相色谱串联质谱法对 α-1-酸性糖蛋白 N-糖肽进行多维分离和分析。

• DOI: 10.1007/s00216-022-04435-3
• 发表时间: 2023
• 期刊: Analytical and bioanalytical chemistry
• 影响因子: 4.3
• 作者: Chandler,KevinBrown;MarreroRoche,DanielE;Sackstein,Robert
• 通讯作者: Sackstein,Robert

Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance.

Cosmc 缺陷会破坏 B 细胞耐受性，从而导致自发性自身免疫。

• DOI: 10.1126/sciadv.abg9118
• 发表时间: 2021-10-08
• 期刊: Science advances
• 影响因子: 13.6
• 作者: Zeng J;Aryal RP;Stavenhagen K;Luo C;Liu R;Wang X;Chen J;Li H;Matsumoto Y;Wang Y;Wang J;Ju T;Cummings RD
• 通讯作者: Cummings RD