A Vevo 3100 Small Animal Ultrasound Machine for the University of Cincinnati

辛辛那提大学的 Vevo 3100 小动物超声机

• 批准号: 10418086
• 负责人: Albert Phillip Owens III
• 金额: $ 40.98万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10418086
• 关键词: 4D Imaging; Anatomy; Animals; Aortic Diseases; Blood Vessels; Cardiac; Cardiovascular system; Clinical Research; Communities; Contract Services; Direct Service Costs; Doctor of Philosophy; Echocardiography; Frequencies; Funding; Future; Heart; Heart Diseases; Heart Rate; Human; Image; Institutes; Kidney Diseases; Lead; Lung; Lung diseases; Measurement; Medical; Morphologic artifacts; Mus; Noise; Oncology; Publications; Reproducibility; Request for Proposals; Research; Research Personnel; Resolution; Scientist; Services; System; Technology; Time; Transducers; Ultrasonography; United States National Institutes of Health; Universities; Visualization; clinical care; cost; end of life; experience; high resolution imaging; improved; in vivo; instrument; repaired; technology development; ultrasound

Project Title: A Vevo 3100 Small Animal Ultrasound Machine for the University of Cincinnati PROJECT SUMMARY/ABSTRACT The current proposal requests funding for upgrading our VisualSonics Vevo 2100 small animal ultrasound machine to a Vevo 3100 system, to be housed and used in the University of Cincinnati Heart, Lung, and Vascular Institute. This system will support the NIH-funded research community at the University of Cincinnati spanning a broad range of investigators from the fields of cardiovascular research in the heart and aorta, lung and kidney diseases, and oncology. The extremely fast heart rate in mice necessitates the use of high frame rates and exceptionally high frequency transducers capable of rapid and high-resolution image acquisition, thus commercially available echocardiography systems for human clinical care and research cannot readily be adapted to provide the temporal and spatial resolution required for detailed assessment of cardiac anatomy and function in mice. At the time of purchase for our original machine (June 2010), the Vevo 2100 system represented the state-of-the-art technology in small animal echocardiography and ultrasound applications that were critical for our researchers to achieve in vivo measurements in their experimental applications and has resulted in more than 60 publications over the last 11 years. Importantly, acquisition of the Vevo 3100 system will markedly improve image quality via the reduction of speckle noise and artifacts allowing for more accurate and reproducible measurements, introduce 4D imaging providing more accurate functional cardiac measurements, and allow faster echocardiography (ECG)-gated kilohertz visualization or EKV, allowing for increased temporal and spatial resolution. Moreover, the Vevo 2100 has received an end-of-life notice from the VisualSonics Corporation and will no longer be maintained, serviced, or repaired as of December 2023. As such, the upgrade to the Vevo 3100 is requested to maintain the high level of in vivo analytics in animal studies at the University of Cincinnati, which are critical to dozens of investigators on the medical campus and open to the University’s other 150 NIH-funded investigators with upwards of 180 million dollars of NIH support annually. Our requested system will be operated by a Ph.D. scientist with 12 years’ experience in all aspects of small animal ultrasonography and this machine is fully supported by the University of Cincinnati to cover the cost of service contracts and technology development to help minimize the direct cost of services to the investigators. Together, proposed use of this instrument will support and enhance existing and future NIH-funded projects and lead to new directions of research for future projects.

项目名称：辛辛那提大学的VEVO 3100小动物超声机 项目摘要/摘要 当前的提案要求资助升级我们的Visualsonics VEVO 2100小动物超声 机器到VEVO 3100系统，将在辛辛那提大学，肺和 血管研究所。该系统将支持辛辛那提大学NIH资助的研究社区 跨越心脏和主动脉中心血管研究领域的广泛研究者，肺 和肾脏疾病和肿瘤学。小鼠的心率极快，需要使用高框架 速率和极高的频率传感器，能够快速和高分辨率图像采集， 因此，可用于人类临床护理和研究的市售超声心动图系统不能轻易地 适应为详细评估心脏解剖所需的临时和空间分辨率 和小鼠的功能。在我们的原始机器购买时（2010年6月），VEVO 2100系统 代表小动物超声心动图和超声应用的最先进技术 对于我们的研究人员在实验应用中实现体内测量至关重要，并且 在过去的11年中，有60多个出版物。重要的是，获取VEVO 3100系统 通过降低斑点噪声和伪影，将显着提高图像质量，从而更准确 和可再现的测量值，引入4D成像提供更准确的功能性心脏 测量并允许更快的超声心动图（ECG）进行kilohertz的可视化或EKV，从而允许 增加临时和空间分辨率。此外，VEVO 2100收到了寿命末通知 截至2023年12月，Visualsonics Corporation将不再维护，维修或维修。 此类，要求对VEVO 3100进行升级，以维持动物研究中的高水平体内分析 在辛辛那提大学（University of Cincinnati），这对于医疗校园的数十名调查人员至关重要 该大学的另外150名NIH资助的调查人员每年有超过1.8亿美元的NIH支持。 我们要求的系统将由博士学位运营。在小型方面拥有12年经验的科学家 辛辛那提大学的动物超声检查和这台机器得到了完全支持 服务合同和技术开发，有助于最大程度地减少对调查人员的直接服务成本。 共同提议使用该工具将支持并增强现有和未来的NIH资助项目 并导致未来项目的研究新方向。