General Motor Control Mechanisms and Disease Training Program

一般运动控制机制和疾病训练计划

基本信息

批准号：
10413880
负责人：
Mark D Bevan
金额：
$ 26.71万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-15 至 2023-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10413880
关键词：
Disease Training Programs motor control

项目摘要

PROJECT SUMMARY/ABSTRACT The ability to initiate, execute, and terminate movement effectively is critical for survival but is impaired in a range of debilitating diseases. Precisely how the nervous system encodes movement and how this neural machinery is compromised by disease remain poorly understood. A primary mission of the neuroscience community is to fill these gaps in our knowledge and translate this new information into better clinical practice. To carry this multi-generational effort forward, it is critical that early career scientists are well- trained. They need a firm grasp of what we know and don't know, experimental skills at the molecular, cellular, and systems levels, and dedication to rigorous, quantitative, and ethical research. With these goals in mind, a group of 30 world-leading basic, clinical and translational motor control scientists have come together under the directorship of Dr. D. James Surmeier to deliver a training program for pre- and post- doctoral scientists committed to motor control research at Northwestern University (NU). The goals of the NU General Motor Control Mechanisms and Disease Training Program (GMCMD-TP) are: 1) to educate trainees in basic, translational, and clinical motor systems neuroscience at the molecular, cellular, and systems levels; 2) to provide trainees with the conceptual, technical, and quantitative skillsets necessary to address major questions, challenge dogma and make impactful research discoveries; 3) to encourage trainees to consider the disease relevance of their research and its translational potential; 4) to instill in trainees a deep commitment to rigorous, ethical, and responsible research; 5) to enhance trainees' skills in communicating their research; 6) to give trainees opportunities to advance their career goals so that we support the next generation of leaders in the field of motor control. Pre-doctoral trainees in the NU Interdepartmental Neuroscience (NUIN) program and the Neural Engineering track of the Biomedical Engineering program, and post-doctoral trainees in the laboratories of program faculty are eligible for the GMCMD-TP. The GMCMD-TP consists of: 1) a core course covering each aspect of the motor system, entitled “The Neural Control of Movement”; 2) monthly seminars by preceptors on their motor control research programs; 3) training and consultation in statistics; 4) an annual retreat where all members of the NU motor control research community come together to communicate and discuss their research; 5) a movement disorders journal club for basic scientists and clinicians; 6) opportunities for shadowing movement disorder clinicians; 7) several annual research center days, each focused on a specific motor control disease. In addition, GMCMD-TP trainees utilize Individual Development Plans and NU professional development programs to further promote career advancement. Each year up to 4 pre-doctoral and 3 post- doctoral trainees will be eligible for direct support for 1-2 years. Trainees in GMCMD-TP labs who do not receive direct support are offered the same training.

项目摘要/摘要有效发起，执行和终止运动的能力对于生存至关重要，但在一系列衰弱的疾病。正是神经系统如何编码运动以及这种中性疾病损害机械仍然知之甚少。神经科学的主要任务社区将在我们的知识中填补这些空白，并将这些新信息转化为更好的临床实践。为了实现这一多代努力，至关重要的是，早期的职业科学家是很好的训练有素。他们需要对我们所知道的和不知道的东西，分子的实验技能，细胞和系统水平以及对严格，定量和道德研究的奉献精神。有这些目标众议院，一组30个世界领先的基本，临床和翻译的运动控制科学家来了在D. James Surmeier博士的主任下共同为前后的培训计划博士科学家致力于西北大学（NU）进行运动控制研究。目标的目标 NU通用运动控制机制和疾病训练计划（GMCMD-TP）为：1）教育基本，翻译和临床运动系统的学员在分子，细胞和系统级别； 2）为受训者提供所需的概念，技术和定量技能解决主要问题，挑战教条并进行有影响力的研究发现； 3）鼓励学员考虑其研究的疾病相关性及其转化潜力； 4）灌输学员对严格，道德和负责任的研究做出了深刻的承诺； 5）提高学员的技能传达他们的研究； 6）为学员提供促进职业目标的机会，以便我们支持运动控制领域的下一代领导者。 NU的博士前学员部门跨部门神经科学（NUIN）计划和生物医学的神经工程轨迹工程课程和课程教师实验室的博士后学员有资格 GMCMD-TP。 GMCMD-TP包括：1）涵盖电机系统各个方面的核心课程，名为“运动的神经控制”； 2）每月下水道通过其电动机控制的受体研究计划； 3）统计培训和咨询； 4）年度务虚会 NU运动控制研究社区聚集在一起进行交流和讨论他们的研究； 5）a 基础科学家和临床医生的运动障碍俱乐部； 6）阴影的机会运动障碍临床医生； 7）几个年度研究中心日，每个研究中心都集中在特定电机上控制疾病。此外，GMCMD-TP培训人员利用个人开发计划和NU专业人员开发计划，以进一步促进职业发展。每年最多4个前博士前和3个博士学员将有资格获得1 - 2年的直接支持。 GMCMD-TP实验室的学员接收直接支持提供相同的培训。

项目成果

期刊论文数量（67）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Intrinsic electrophysiology of mouse corticospinal neurons: a class-specific triad of spike-related properties.

小鼠皮质脊髓神经元的内在电生理学：尖峰相关特性的类特异性三联体。

DOI：
10.1093/cercor/bhs184
发表时间：
2013
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
0
作者：
Suter,BenjaminA;Migliore,Michele;Shepherd,GordonMG
通讯作者：
Shepherd,GordonMG

Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects.

DOI：
10.1016/j.brainres.2014.01.010
发表时间：
2014-03-06
期刊：
BRAIN RESEARCH
影响因子：
2.9
作者：
Khodr, Christina E.;Becerra, Amanda;Han, Ye;Bohn, Martha C.
通讯作者：
Bohn, Martha C.

Stabilization of Ca current in Purkinje neurons during high-frequency firing by a balance of Ca-dependent facilitation and inactivation.

DOI：
10.4161/chan.3.6.9838
发表时间：
2009-11
期刊：
Channels (Austin, Tex.)
影响因子：
0
作者：
Benton MD;Raman IM
通讯作者：
Raman IM

Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor.

DOI：
10.1038/mp.2010.78
发表时间：
2011-10
期刊：
MOLECULAR PSYCHIATRY
影响因子：
11
作者：
Xu, J.;Cohen, B. N.;Zhu, Y.;Dziewczapolski, G.;Panda, S.;Lester, H. A.;Heinemann, S. F.;Contractor, A.
通讯作者：
Contractor, A.

Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells.