Neuroimaging Core

神经影像核心

基本信息

批准号：
10413838
负责人：
KEJAL KANTARCI
金额：
$ 100.52万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10413838
关键词：
African American Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Amyloid beta-Protein Autopsy Award Biological Classification Clinic Clinical Clinical Trials Collaborations Communities Complex Confidentiality of Patient Information Data Data Analyses Dementia Dementia with Lewy Bodies Deposition Development Diagnosis Diagnostic Education and Outreach Elderly Enrollment Faculty Florida Frontotemporal Lobar Degenerations Genetic Risk Goals Image Imaging technology Impaired cognition Lead Light Magnetic Resonance Imaging Multimodal Imaging Nerve Degeneration Neurodegenerative Disorders Operations Research Participant Pathology Patients Positron-Emission Tomography Procedures Process Proteins Protocols documentation Quality Control Race Research Research Personnel Research Project Grants Resources Role Sensitivity and Specificity Site Staging Standardization Symptoms Training Training Support alpha synuclein career catalyst cerebrovascular lesion cerebrovascular pathology cohort data management data resource design diagnostic criteria education research fluorodeoxyglucose positron emission tomography high resolution imaging image processing imaging biomarker imaging program imaging study individual patient innovation innovative technologies multimodal neuroimaging neuroimaging neuroimaging marker neuropathology next generation nonalzheimer dementia outreach pre-clinical programs protein TDP-43 racial diversity radioligand recruit sex risk single photon emission computed tomography tau Proteins

项目摘要

PROJECT DESCRIPTION/ABSTRACT – NEUROIMAGING CORE The primary goal of the Neuroimaging Core is to provide imaging biomarker data for diagnostic classification and staging of AD and other dementias, for research projects and clinical trials on ADRC participants, through a harmonized multimodality neuroimaging program at the Mayo Clinic Rochester (MCR) and Mayo Clinic Florida (MCF) sites. A cohort of African American participants from the MCF will be recruited in order to enhance the racial diversity of the multimodality neuroimaging program in the ADRC. The aims of the Neuroimaging Core include: 1) Establishing and maintaining a harmonized MRI, β-amyloid, tau, and FDG PET and DaTScan SPECT imaging program for the Mayo Clinic ADRC, and operating a standardized quality control, image processing and data analysis program for the ADRC cohorts including the African American Cohort in MCF; 2) Support imaging studies and supply imaging biomarker data to the research projects and clinical trials, and the National Alzheimer's Coordinating Center (NACC), while protecting patient confidentiality when sharing high-resolution images; 3) Educating the research community, training, supporting, and enhancing the careers of the next generation of investigators in the aging and dementia neuroimaging biomarkers field. Neuroimaging Core will collaborate with the Clinical Core and the Outreach and Education Core on recruitment of clinically characterized African American participants to imaging studies, with the Neuropathology Core on autopsy confirmation of imaging findings, with the Data Management Core on sharing of the imaging biomarker data with the research community, and with the Research Education Component on training junior faculty. It is expected that the Neuroimaging Core will impact ADRC research operations and National Alzheimer's Coordinating Center (NACC) as an advanced imaging biomarker data resource.

项目描述/摘要 - 神经影像核心神经成像核心的主要目标是提供成像生物标志物数据以进行诊断用于研究项目和ADRC的临床试验的AD和其他痴呆症的分类和分期参与者，通过梅奥诊所罗切斯特的统一多模式神经影像学计划（MCR）和Mayo Clinic Florida（MCF）地点。来自MCF的非裔美国人参与者将是为了增强ADRC中多模式神经影像计划的种族多样性而招募。神经影像学核心的目的包括： 1）建立和维持统一的MRI，β-淀粉样蛋白，TAU和FDG PET和DATSCAN Mayo Clinic ADRC的SPECT Imaging计划，并运行标准化质量控制，包括非裔美国人在内的ADRC队列的图像处理和数据分析计划 MCF的队列； 2）支持成像研究并为研究项目和临床提供成像生物标志物数据试验和国家阿尔茨海默氏症协调中心（NACC），同时保护患者共享高分辨率图像时的机密性； 3）教育研究社区，培训，支持和增强下一步的职业衰老和痴呆症神经成像生物标志物领域的研究者产生。神经影像核心将与临床核心以及外展和教育核心合作招募临床表征非裔美国人参与者成像研究，神经病理学核心对成像发现的尸检确认，并具有数据管理核心与研究社区以及研究教育共享成像生物标志物数据培训初级教师的组成部分。预计神经影像核心将影响ADRC研究运营和国家阿尔茨海默氏症协调中心（NACC）作为高级成像生物标志物数据资源。