Administrative Core

行政核心

• 批准号: 10413093
• 负责人: SCOTT A SMALL
• 金额: $ 77.47万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10413093
• 关键词: Administrator; Advisory Committees; Advocacy; Alzheimer' s Disease; Alzheimer' s disease therapeutic; Awareness; Bioethics; Biological; Charge; Cholesterol Homeostasis; Collaborations; Data; Development; Disease; Environment; Exercise; Fostering; Funding; Genetic; Goals; Immune response; Institution; Intervention; Leadership; Mind; Mission; Monitor; National Institute on Aging; Neurologic; Neuropsychology; Outreach Research; Participant; Pathogenicity; Pathway interactions; Patient Care; Patient Recruitments; Patients; Process; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Time; Training; Universities; Vision; Work; career; cell repository; community center; cooperative study; education research; flexibility; high standard; imaging biomarker; innovative technologies; interdisciplinary collaboration; meetings; outreach; prevent; programs; ranpirnase; recruit; trafficking

ADMINISTRATIVE CORE PROJECT SUMMARY/ABSTRACT The general goals of this application for a new P30 ADRC at Columbia University include creating an infrastructure for research on AD and related disorders, fostering interdisciplinary collaborations across many departments, providing a rich training environment, and supporting outreach and patient recruitment. More globally, the goals of our Center will extend to include participation in national coordinating efforts, working with the national network of AD centers, and working with the National Institute on Aging and other organizations in their advocacy efforts. Embedded within the general goals, the Center’s thematic goal will be on better understanding the three biological pathways now considered to act as pathogenic drivers in AD: An ‘immune response’ pathway, a ‘cholesterol metabolism’ pathway, and an ‘endosomal trafficking’ pathway. Both the general and thematic goals were conceived with NAPA’s ambitious milestones in mind-- to prevent or treat AD and related disorders, to optimize patient care, to extend patient support, and to enhance public awareness. The Administrative Core will act as the executive governing body of the Center that, with the guidance of its various committees, will provide the vision and leadership necessary to achieve the Center’s general and thematic goals. The Core will implement this vision by exercising managerial oversight over all aspects of the Center, which includes assuring the highest standards of scientific and bioethical conduct, and a judicious use of resources and funds. More specifically, the Core will achieve its goals by: Directing regular meeting with the Center’s Core leaders and administrators; working with an external and internal advisory committee; assuring delivery of data and biospecimens to investigators and to national consortia; and assuring and enhancing the Center’s community outreach and research education mission.

行政核心项目摘要/摘要 该应用程序在哥伦比亚大学进行新的P30 ADRC的一般目标包括创建一个 用于广告和相关疾病的研究基础架构，促进许多跨学科合作 部门，提供丰富的培训环境，并支持外展和患者招募。更多的 在全球范围内，我们中心的目标将扩展到包括参与国家协调努力，与之合作 全国广告中心网络，并与国家老化研究所和其他组织合作 他们的倡导努力。中心的主题目标嵌入了一般目标中，将会更好 了解现在被认为是AD中充当致病驱动因素的三种生物学途径：“免疫” 反应途径，“胆固醇代谢”途径和“内体贩运”途径。两者 纳帕的雄心勃勃的里程碑构想了一般和主题目标，以防止或治疗广告 以及相关疾病，以优化患者护理，扩大患者支持并提高公众意识。 行政核心将充当中心的执行机构，在其指导下 各种委员会将提供实现该中心将军的必要愿景和领导 主题目标。核心将通过操作管理管理的各个方面来实现这一愿景 中心，其中包括确保科学和生物伦理行为的最高标准以及明智的使用 资源和资金。 更具体地说，核心将通过：与中心的核心领导者定期会议来实现其目标 和管理员；与外部和内部咨询委员会合作；确保数据交付和 对调查人员和国家宪法的生物测量；并确保和增强中心社区 外展和研究教育任务。