Resilience, cultural alignment, and social support in brain aging: Data from the Strong Heart Study

大脑衰老过程中的复原力、文化一致性和社会支持：来自强心研究的数据

• 批准号: 10408836
• 负责人: Astrid M Suchy-Dicey
• 金额: $ 59.02万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408836
• 关键词: Address; Adult; Age; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Anger; Anthropology; Behavioral; Cardiovascular Diseases; Characteristics; Chronic; Chronic stress; Clinic; Clinical; Cognition; Cohort Studies; Communities; Consent; Contracts; Data; Data Analyses; Data Collection; Dementia; Development; Discrimination; Emotional; Emotions; Environment; Epidemiology; Event; Failure; Family; Female; Funding; Health; Heart; Hostility; Impaired cognition; Individual; Inflammation; Knowledge; Life; Life Stress; Link; Longitudinal cohort; Machine Learning; Mediating; Medical Genetics; Mental Depression; Methods; Modeling; National Heart, Lung, and Blood Institute; Navajo; Nerve Degeneration; Neuropsychology; Outcome; Participant; Patient-Centered Care; Persons; Philosophy; Population; Poverty; Protocols documentation; Psychosocial Factor; Public Health; Quality of life; Recording of previous events; Reporter; Research; Resources; Risk; Social Network; Social support; Socioeconomic Factors; Spirituality; Stress; Time; Trauma; Tribes; Underserved Population; United States National Institutes of Health; Work; Youth; aging brain; base; bullying; clinical examination; cognitive function; cognitive reserve; cohort; disability; eligible participant; epidemiology study; experience; healthy aging; heterogenous data; improved; instrument; intergenerational; machine learning classification; male; mortality; novel; optimism; practical application; psychosocial; public health intervention; recruit; resilience; screening; sex; sociodemographics; socioeconomics; theories; trait; tribal community

ABSTRACT When life stresses are especially intense, chronic, or overwhelming, deleterious health effects can occur, including inflammation, cardiovascular disease, disability, depression, low quality of life, and dementia. In this context, resilience can be defined as the ability to maintain a healthy aging trajectory despite adverse conditions of stress. American Indians (AI) have a unique history and ongoing experience of trauma and disparities in environmental and socioeconomic conditions, which amplify daily stresses and contribute to health risks. Despite these adverse circumstances, remarkable resilience has been described in AI populations. Recent work by our group suggests that social support and alignment with Native culture correlate with lower levels of stress, negativity, anger, hostility, depression, mortality, and cardiovascular disease. However, our findings on cultural alignment are limited, and none has yet explored associations of resilience and social support. It remains an open question whether neurodegenerative conditions such as Alzheimer's disease and related dementias (ADRD) can result from chronic stress, or whether individual psychosocial characteristics such as resilience can mediate such risk. We propose to address these knowledge gaps by efficiently leveraging an existing effort funded by the NHLBI in the Strong Heart Study, a longitudinal cohort of AI adults from 13 tribal communities across the US. The existing contract covers recruitment, consenting, and basic clinical examination of 3,000 eligible participants in 2022-2024; we propose to augment the limited protocol by administering additional psychosocial and neuropsychological instruments on resilience, social support, cultural identity and alignment, and cognition. Our Specific Aims are to: describe associations of individual resilience among AI adults with identity and self-regard, social support, and cultural alignment, by age and sex; evaluate resilience, social support, and cultural features in relation to ADRD; and use machine learning to develop explanatory models of resilience and dementia. Our study has the potential to advance epidemiologic knowledge of modifiable psychosocial conditions in a vulnerable, underserved population, and consequently to offer a clearer picture of the relative contributions of psychosocial, behavioral, interpersonal, and socioeconomic factors related to ADRD.

抽象的 当生活压力特别紧张，慢性或压倒性时，可能会发生有害的健康影响， 包括炎症，心血管疾病，残疾，抑郁症，生活质量低和痴呆症。在这个 上下文，弹性可以定义为尽管条件不良，但仍能保持健康的衰老轨迹 压力。美洲印第安人（AI）具有独特的历史和持续的创伤和差异经验 环境和社会经济状况，这会扩大日常压力并导致健康风险。尽管 在AI人群中描述了这些不利的情况，显着的弹性。我们最近的工作 小组表明，社会支持和与天然文化的一致性与压力水平较低相关， 消极，愤怒，敌对，抑郁，死亡率和心血管疾病。但是，我们关于文化的发现 一致性是有限的，而且还没有探索韧性和社会支持的关联。它仍然是一个 开放问题神经退行性疾病（例如阿尔茨海默氏病和相关痴呆症）是否存在 （ADRD）可能是由于慢性压力而引起的，或者是诸如韧性之类的个人社会心理特征是否可以 调解这种风险。我们建议通过有效利用现有的努力来解决这些知识差距 由NHLBI资助在强大的心脏研究中，来自13个部落社区的AI成年人的纵向队列 整个美国。现有合同涵盖了3,000的招聘，同意和基本临床检查 2022 - 2024年合格的参与者；我们建议通过管理其他 关于弹性，社会支持，文化身份和一致性的心理和神经心理学工具， 和认知。我们的具体目的是：描述AI成年人与 身份和自我叙述，社会支持和文化结盟，按年龄和性别来划分；评估弹性，社会 支持和与ADRD有关的文化特征；并使用机器学习来开发 弹性和痴呆症。我们的研究有可能提高对可修改的流行病学知识 在脆弱，服务不足的人群中的社会心理状况，因此可以更清楚地了解 与ADRD有关的社会心理，行为，人际和社会经济因素的相对贡献。