Training in Basic Research on Aging and Age-Related Disease

衰老和年龄相关疾病基础研究培训

• 批准号: 10407581
• 负责人: Judith Campisi
• 金额: $ 65.34万
• 依托单位: BUCK INSTITUTE FOR RESEARCH ON AGING
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407581
• 关键词: Aging; Basic Science; Disease; Training; age related

PROJECT SUMMARY Age is the largest single risk factor for the majority of diseases seen in clinics throughout the U.S. Demo- graphic calculations predict that eliminating any single age-related disease would produce only a modest in- crease in human health span (years of healthy life) or life span. However, postponing or decreasing the rate of aging would retard the course of multiple age-related diseases and thus substantially increase health span and likely life span. Our ability to develop rational approaches to preventing or intervening in the debilitating and costly consequences of aging depends crucially on a thorough understanding of the causes of aging and how they interact with the etiology of specific age-related diseases. Training young scientists to integrate research on basic aging mechanisms with mechanisms of specific age-related diseases is a critical objective of this ap- plication. The long-term goal of this training program is to provide exceptional young scientists with the broad knowledge, skills and interactions they will need to mitigate, through research, the enormous human and finan- cial burdens caused by aging and age-related diseases. This program will train postdoctoral fellows to become future leaders in aging research. Each year, the program will train 10 talented postdoctoral scientists who will conduct research for a 2-year period in one or more of 36 laboratories headed by outstanding preceptors at the Buck Institute for Research on Aging, Lawrence Berkeley National Laboratory, University of California, Berke- ley and Stanford University. Trainees will participate in research projects that include basic mechanisms of cellular stress responses, protein homeostasis, genomic and epigenomic stability, stem cell maintenance, bio- energetics and energy metabolism and hormonal, growth factor and nutrient signaling pathways. They will uti- lize a variety of model systems including yeast, round and flat worms, fruit flies, fish, mice and human cells and tissues. And they will focus on an array of age-related diseases including Alzheimer's, Parkinson's and Hun- tington's diseases, stroke, cardiac and vascular dysfunction, cancer, diabetes, osteoporosis and sarcopenia. Trainees will be instructed in state-of-the-art techniques in genomics, epigenomics, drug screening, proteomics and metabolomics, as well as genetics, biochemistry, structural biology, cell biology, and cell and organismal imaging. They will receive the benefits of diverse seminar series and other scientific events and frequent net- working opportunities. They will also attend courses in specialized scientific topics, as well as courses or dis- cussion groups on geriatric medicine, ethics, presentation skills, proposal and manuscript writing, and laborato- ry management skills. The program will fill an important national and international need for high-quality ad- vanced training that integrates basic aging research with research on age-related disease.

项目摘要 年龄是美国诊所中大多数疾病的最大危险因素 图形计算预测，消除任何与年龄相关的疾病只会产生适度 人类健康跨度（健康的生命年）或寿命的折痕。但是，推迟或降低 衰老会阻碍多种年龄相关疾病的过程，从而大大增加健康范围 可能的寿命。我们开发理性方法的能力，以防止或干预衰弱的和 衰老的昂贵后果至关重要地取决于对衰老原因的彻底理解以及如何 它们与特定年龄相关疾病的病因相互作用。培训年轻科学家整合研究 关于具有特定年龄相关疾病机制的基本老化机制，是该问题的关键目标 盘子。 该培训计划的长期目标是为杰出的年轻科学家提供广泛的 他们将需要进行的知识，技能和互动，以减轻研究 由衰老和与年龄有关的疾病引起的cial负担。该计划将训练博士后研究员成为 衰老研究的未来领导者。每年，该计划将培训10位才华横溢的博士后科学家 在36个实验室中的一个或多个由未杰出受体的实验室中的一个或多个进行研究的研究 劳伦斯·伯克利国家实验室，加利福尼亚大学劳伦斯·伯克利国家实验室衰老研究所 莱和斯坦福大学。受训人员将参加包括包括基本机制的研究项目 细胞应激反应，蛋白质稳态，基因组和表观基因组稳定性，干细胞维持，生物 能量和能量代谢以及激素，生长因子和营养信号通路。他们会 利兹各种模型系统，包括酵母，圆形和扁平蠕虫，果蝇，鱼，小鼠和人类细胞，以及 组织。他们将专注于一系列与年龄有关的疾病，包括阿尔茨海默氏症，帕金森氏症和匈奴 廷顿的疾病，中风，心脏和血管功能障碍，癌症，糖尿病，骨质疏松症和肌肉减少症。 学员将接受基因组学，表观基因组学，药物筛查，蛋白质组学的最先进技术的指导 以及代谢组学以及遗传学，生物化学，结构生物学，细胞生物学以及细胞和生物 成像。他们将获得各种研讨会系列和其他科学事件的好处，并经常进行网络 工作机会。他们还将参加专业科学主题的课程，课程或分读 关于老年医学，道德，演示技巧，建议和手稿写作的狂暴群体以及劳动 RY管理技能。该计划将满足对高质量广告的重要国家和国际需求 将基本衰老研究与与年龄相关疾病的研究相结合的训练训练。