Training in the Neurobiology of Aging and Alzheimer's Disease

衰老和阿尔茨海默病的神经生物学培训

• 批准号: 10407596
• 负责人: MICHAEL J. FORSTER
• 金额: $ 39.14万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407596
• 关键词: Aging; Alzheimer' s Disease; Neurobiology; Training

Summary With the “graying of America” we are faced with the need to address the ever increasing number of individuals in our society who have age-associated nervous system diseases and conditions. To address this problem, we need multidisciplinary approaches to facilitate the discovery of the mechanisms, treatments and prevention of these diseases. Active, integrated research-based training of pre-doctoral students is a key to re-supplying the research personnel needed to address these biomedical health care issues in a sustainable manner. Herein we propose to continue a successful pre-doctoral program at the University of North Texas Health Science Center (UNTHSC) that focuses on the neurobiology of aging. During this funding cycle we supported 33 fellows, of whom 22 completed their training and their Ph.D. The trainees were very productive and published 46 peer-reviewed papers to date; we also trained 7 (of 33 = 21.2%) minority students. Importantly, we increased our retention/graduation rate from 84.6% in the prior 5-year funding period to 100% in the most recent funding cycle. The proposed training program will enhance an already strong and successful training program in the neurobiology of aging. The continuation of our predoctoral training program is proposed, as our Institute for Healthy Aging has matured through the addition of faculty and continued funding of program project grants, such as that led by the PI, Dr. Meharvan Singh. Such growth has facilitated more basic, translational and clinical research into the causes, treatment and prevention of brain aging and Alzheimer's Disease at the UNTHSC. Collectively, these new initiatives create a stimulating environment for the training of predoctoral students in the neurobiology of aging. Unique and innovative features of the training program for the next period of funding include: (1) Several experiential learning opportunities to include the Geriatrics Skills Lab and the Translational Aging & Alzheimer's Disease Research Program; (2) our continued emphasis on diversity training, that resulted in greater than 20% minority participation in the training program; 3) Career counseling and interview skill development program, 4) techniques in neuroscience program; 5) our institutional support which will expand those students who will have access to some or all of this training program; 6) our focus on the development of research excellence and leadership among our trainees; and 7) our Mentoring-the-Mentor Program which trains junior faculty in mentoring trainees under the guidance of a senior faculty. Collectively, these attributes of our Neurobiology of Aging Training Program has produced an outstanding program of training that we wish to continue.

概括 随着“美国的老龄化”，我们面临着解决日益增加的问题的需要。 我们社会中患有与年龄相关的神经系统疾病和状况的个人。 为了解决这个问题，我们需要多学科的方法来促进发现 这些疾病的机制、治疗和预防基于积极、综合的研究。 博士后培养是补充科研人才的关键 我们在此建议以可持续的方式解决这些生物医学保健问题。 继续在北德克萨斯大学健康科学学院成功完成博士前课程 中心（UNTHSC）专注于衰老的神经生物学。 资助了 33 名研究员，其中 22 人完成了培训并获得博士学位。 迄今为止，我们已发表了 46 篇经过同行评审的论文，成果非常丰富；我们还培训了 7 篇（共 33 篇） 21.2%) 重要的是，我们的保留率/毕业率从 2018 年的 84.6% 提高了。 在最近的资助周期中将之前 5 年的资助期限提高到 100%。 该计划将加强已经强大且成功的神经生物学培训计划 建议继续开展我们的博士前培训计划，作为我们的老龄化研究所。 通过增加教师和持续资助项目，健康老龄化已经成熟 项目资助，例如由 PI Meharvan Singh 博士领导的项目资助，这种增长促进了更多。 脑部病因、治疗和预防的基础、转化和临床研究 UNTHSC 的老龄化和阿尔茨海默氏病总体而言，这些新举措创造了一个新的目标。 为衰老神经生物学博士前学生的培训提供刺激的环境。 下一期资助的培训计划独特和创新的特点包括：（1） 一些体验式学习机会，包括老年病学技能实验室和 转化衰老与阿尔茨海默病研究计划；(2) 我们持续强调 多元化培训，使超过 20% 的少数族裔参与培训计划； 3) 职业咨询和面试技巧发展计划，4) 神经科学技术 5）我们的机构支持将扩大那些有机会接触的学生 该培训计划的部分或全部；6）我们注重卓越研究的发展； 学员中的领导力；以及 7) 我们培训初级学员的导师计划 总的来说，这些属性是在高级教师的指导下指导学员的。 我们的衰老神经生物学培训计划制定了出色的培训计划 我们希望继续下去。