Mechanisms that underlie cross-modal sensory plasticity - Diversity Research Supplements to Promote Diversity in Health-Related Research

跨模式感觉可塑性的机制 - 促进健康相关研究多样性的多样性研究补充

• 批准号: 10404187
• 负责人: BING YE
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404187
• 关键词: Affect; Animals; Behavioral Model; Complement; Cues; Development; Drosophila genus; Ensure; FMRP; Financial compensation; Future; Genes; Goals; Grant; Habitats; Health; Individual; Individual Differences; Knowledge; Larva; Learning; Mission; Modality; Molecular; Neurodevelopmental Disorder; Neurons; Nociceptors; Oral; Parents; Perception; Positioning Attribute; Public Health; Research; Research Activity; Sensory; Sensory Deprivation; Synaptic Transmission; System; Training; Training Support; United States National Institutes of Health; Writing; behavioral plasticity; career; experience; improved; mature animal; molecular modeling; multimodality; multisensory; nervous system disorder; parent grant; relating to nervous system; sensory stimulus; sensory system; skills; somatosensory; synaptic inhibition

PROJECT SUMMARY Sensory experiences during development profoundly influence sensory processing in mature animals. Since most of an animal’s sensory experiences are multimodal, the activity of one sensory modality often causes long-term changes in another modality. Such cross-modal plasticity not only leads to compensation for sensory functions in the case of sensory deprivation, but also allows normal individuals to respond properly to sensory stimuli in their unique habitats or situations and contributes to individual’s differences in the perception of multisensory cues. Despite the importance of cross-modal plasticity, the underlying circuit and molecular mechanisms are poorly understood. The objective of the parent grant R01NS104299 is to identify the mechanisms that underlie cross-modal plasticity in the developing somatosensory system of Drosophila larvae, and provide circuit and molecular models for guiding future studies in other species. The central hypothesis is that gentle mechanosensory inputs during development strengthen serotonergic inhibition of the synaptic transmission from nociceptors to multisensory second-order neurons (MSONs), which is achieved through specific genes in the MSONs. The requested Research Supplement to Promote Diversity in Health-Related Research will support the training of an outstanding postbaccalaureate. The research proposed will supplement the originally proposed studies to ensure the successful attainment of its aims. Two studies are proposed to supplement the original Aim 2: (1) determine whether FMRP is required for cross-model behavioral plasticity; and (2) determine whether cross-modal plasticity affects neural ensemble activities. These research activities will expand the research experiences of the supplementee. Moreover, they will provide opportunities for her to learn scientific writing, oral presentation skills, and networking. These training will position her strongly for a health-related research career.

项目摘要 发育过程中的感觉体验深刻影响成熟动物的感觉处理。自从 动物的大多数感觉体验都是多模式的，一种感官方式的活动通常是原因 另一种方式的长期变化。这种跨模式的可塑性不仅会导致补偿 在感官剥夺的情况下，感觉功能，但也允许普通个人做出正确的反应 在其独特的栖息地或情况下进行感官刺激，并有助于个人在 多感官提示的感知。尽管具有跨模式可塑性的重要性，但基础电路和 分子机制知之甚少。父母授予R01NS104299的目的是确定 果蝇发展中的体感系统中跨模式可塑性的基础的机制 幼虫，并提供电路和分子模型，用于指导其他物种的未来研究。中央 假设是发育过程中温和的机制输入更强的血清能抑制 从伤害感受器到多感觉二阶神经元（MSON）的突触传播， 通过MSON中的特定基因实现。要求的研究补充以促进多样性 在与卫生有关的研究中，将支持培训出色的后核后龙。研究 拟议的将补充最初提出的研究，以确保成功实现其目标。 提出了两项​​研究以补充原始目标2：（1）确定是否需要FMRP 跨模型行为可塑性； （2）确定跨模式可塑性是否影响神经合奏 活动。这些研究活动将扩大补品的研究经验。而且， 他们将为她提供学习科学写作，口头演示技巧和网络的机会。 这些培训将在与健康相关的研究职业中强烈定位。