Coordinating an ACE studying IgG4-related diseases

协调 ACE 研究 IgG4 相关疾病

• 批准号: 10394915
• 负责人: SHIV Subramaniam PILLAI
• 金额: $ 8.4万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10394915
• 关键词: Autoimmune; Autoimmune Diseases; Autoimmunity; Cells; Characteristics; Chromatin; Code; Collaborations; Communities; Country; Data; Databases; Disease; Ensure; Equipment and supply inventories; Fruit; General Hospitals; Goals; Hospitals; Hour; Human; IgG4; Immune; Immunology; Institutes; Location; Massachusetts; Mediating; Michigan; Patients; Pilot Projects; Principal Investigator; Research; Research Personnel; Resources; Sampling; Systemic Scleroderma; Techniques; Time; Tissues; data sharing; interest; meetings; member; microbial community; next generation sequencing; programs; sample collection; symposium; tool; working group

Project Summary This Administrative Core will mediate three functions. As part of the first function it will help coordinate the Principal Project, the Collaborative Project and the Pilot Project. At a fixed time on the first Monday of every month the project coordinator and the Investigators and Co- investigators of the three projects will meet face to- face or by conference call at Massachusetts General Hospital to chart progress and coordinate studies and sample collection. These meetings will expand on ongoing regular monthly meetings currently being held. A second goal of this Core will be to make available tools of Human Immunology research to other investigators at MGH studying autoimmune disorders other than lgG4-Related Disease including Next Gen sequencing for repertoire, expertise with investigating immune cells and tissues in depth, cell storage and profiling techniques. The ACE program coordinator will regularly inform the broader MGH community of the time and location of the monthly meetings and an hour will be set aside by the Principal Investigator to meet clinicians and other investigators at the MGH who seek to interact. These interactions will also facilitate some of the studies of the Principal Project on the causes of IgG4 related disease and systemic sclerosis. The third goal of this Core and its coordinator will be to generate a portal for interaction with other ACEs and to share information on Immune repertoires, microbial community characteristics and chromatin data with other groups working across the country on autoimmunity, not necessarily restricted to other ACEs.

项目概要 该行政核心将协调三项职能。作为第一个功能的一部分，它将有所帮助 协调主体项目、合作项目和试点项目。在固定时间 每个月的第一个星期一，项目协调员、调查员和合作者 这三个项目的研究人员将在马萨诸塞州进行面对面或电话会议 总医院绘制进度图并协调研究和样本收集。这些 会议将扩大目前正在举行的每月定期会议的范围。第二个进球 该核心的目的是向其他人提供人类免疫学研究的工具 MGH 的研究人员研究 IgG4 相关疾病以外的自身免疫性疾病 包括下一代测序库、研究免疫细胞的专业知识和 组织深度、细胞储存和分析技术。 ACE 项目协调员将 定期向 MGH 社区通报每月会议的时间和地点 首席研究员将留出一个小时来会见临床医生和其他人员 麻省总医院的调查人员寻求互动。这些互动也将促进一些 主要项目关于 IgG4 相关疾病和系统性硬化症的原因的研究。 该核心及其协调员的第三个目标是生成一个与 其他 ACE 并分享有关免疫库、微生物群落的信息 与全国其他小组合作研究特征和染色质数据 自身免疫，不一定限于其他 ACE。