Molecular Genetics Resource Core

分子遗传学资源核心

基本信息

批准号：
10394249
负责人：
Charles Chavkin
金额：
$ 44.71万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10394249
关键词：
Adenovirus Vector Behavioral Biological Models CRISPR/Cas technology Canis familiaris Cell physiology Cells Communities Consultations Development Disease Dissection Educational workshop Evolution Excision Functional disorder Gene Expression Gene Targeting Generations Genetic Genetic Techniques Glutamates Goals Imaging technology Investigation Mediating Methodology Methods Molecular Molecular Genetics Monitor Monkeys Mus National Institute of Drug Abuse Neuraxis Neuropeptides Opiate Addiction Opioid Pathway Analysis Post-Translational Protein Processing Postdoctoral Fellow Potassium Channel Process Proteomics Rattus Research Research Personnel Research Support Resolution Resources Scientist Services Signal Transduction Specificity Standardization Substance Use Disorder Synaptic Transmission Training Training and Education Transgenic Organisms Translations Universities Validation Viral Viral Vector Washington addiction base career delivery vehicle design drug of abuse gamma-Aminobutyric Acid genetic approach genetic resource graduate student high resolution imaging improved in vivo in vivo imaging innovation neural circuit new technology next generation novel optogenetics promoter protein transport ranpirnase sensor tool undergraduate student vector virus genetics

项目摘要

Molecular Genetics Resource Core – Summary The Molecular Genetics Resource Core (MGRC) will provide a variety of services for the University of Washington Center for Excellence in Opioid Research. We will provide state-of-the-art viral vectors for neural circuit dissection, generate numerous viral-based CRISPR/Cas9 targeting vectors for in vivo molecular circuit analysis, and provide access to platforms for the viral delivery of novel sensors and actuators developed by UW addiction researchers. The UW MGRC will also generate novel mouse lines for UW addiction researchers and provide access to existing mouse lines for researcher initiated investigations. A major provision of the UW MGRC will be hands on training in molecular genetics techniques for graduate students, postdoctoral fellows, and qualified undergraduates. We will also provide a Summer Workshop for the education and training of UW addiction research trainees. Collectively the resources, education, and training provided by the UW MGRC will facilitate the rapid dissemination of cutting-edge research on the molecular and genetic basis of opioid addiction and prepare the next generation of scientists for careers in substance use disorder research.

分子遗传学资源核心 – 摘要分子遗传学资源核心（MGRC）将为大学提供各种服务华盛顿阿片类药物研究卓越中心我们将为神经提供最先进的病毒载体。电路解剖，为体内分子电路生成大量基于病毒的 CRISPR/Cas9 靶向载体分析，并提供对由病毒式传播的新型传感器和执行器开发的平台的访问华盛顿大学成瘾研究人员还将为华盛顿大学成瘾研究人员培育新的小鼠品系。并为研究人员发起的调查提供现有的小鼠品系的访问权，这是华盛顿大学的一项主要规定。 MGRC 将为研究生、博士后、我们还将为华盛顿大学的教育和培训提供暑期研讨会。威斯康辛大学 MGRC 提供的资源、教育和培训将共同提供给成瘾研究学员。促进阿片类药物分子和遗传基础的前沿研究的快速传播成瘾并为下一代科学家从事物质使用障碍研究的职业做好准备。