Core A: Administrative Core

核心A：行政核心

基本信息

批准号：
10394315
负责人：
Alexander Bukreyev
金额：
$ 36.12万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10394315
关键词：
Address Administrator Advisory Committees Biometry Clinical Management Collaborations Communication Containment Core Facility Coronavirus Data Decision Making Dengue Development Ebola virus Electronic Mail Ensure Evaluation Evaluation Research Experimental Designs Funding Future Genetic Transcription Goals Grant Human Resources Immune response Infection Information Dissemination Institution Intellectual Property Investigation Knowledge Laboratories Lead Leadership Marburgvirus Medical Mission Molecular National Institute of Allergy and Infectious Disease Occupational activity of managing finances Online Systems Pediatric Hospitals Policies Preparation Process Productivity Progress Reports Reporting Research Research Personnel Research Project Grants Resource Allocation Resources Scientific Evaluation Scientist Security Site Site Visit Strategic Planning Structure System Texas United States National Institutes of Health Universities Vertebrates Videoconferencing Virus Diseases Work biosafety level 4 facility experience meetings member novel strategies operation pathogenic virus product development programs synergism

项目摘要

ADMINISTRATIVE CORE (Core A): PROJECT SUMMARY/ABSTRACT The Administrative Core is responsible for the strategic planning, overall management, and coordination of the Program Project (P01) “Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus”. It provides governance, financial oversight, and operational management functions to facilitate the execution of the overall research plan, thereby enabling the Program to fulfill its mission to characterize the transcriptional, posttranscriptional, and posttranslational mechanisms following Ebola virus infection that lead to the dysregulated immune response. The Administrative Core will provide an organizational and programmatic structure to promote research productivity and synergy through scientific interactions. The Core will provide oversight in setting priorities, including decision-making processes involving the continual evaluation of research by the PIs and an advisory board. Core personnel will ensure that the Program includes biostatistical rigor and is compliant with issues involving the use of vertebrate animals, select agents, and BSL-4 facilities, and will ensure that regulatory expertise is available for future product development activities. Management activities are carried out with the advice of the External Advisory Committee in close collaboration with Core leadership. Emails, teleconferencing, and videoconferencing are maximally utilized to facilitate communication between the University of Texas Medical Branch, the lead institution for the P01, and participating institutions.

行政核心（核心 A）：项目摘要/摘要行政核心负责战略规划、总体管理和协调计划项目（P01）“埃博拉病毒免疫反应失调的分子机制”。提供治理、财务监督和运营管理职能，以促进执行总体研究计划，从而使该计划能够履行其表征转录、埃博拉病毒感染后的转录后和翻译后机制导致失调的免疫反应将提供组织性和程序性的。核心将提供通过科学互动提高研究生产力和协同作用的结构。监督确定优先事项，包括涉及持续评估研究的决策过程由 PI 和顾问委员会负责，确保该计划包括生物统计的严谨性和准确性。遵守涉及脊椎动物使用、选定制剂和 BSL-4 设施的问题，并将确保监管专业知识可用于未来的产品开发活动。根据外部咨询委员会的建议并与核心领导层密切合作进行。最大限度地利用电子邮件、电话会议和视频会议来促进双方之间的沟通德克萨斯大学医学分部、P01 的牵头机构和参与机构。