Training Grant on Alzheimer's Disease and ADRD at Indiana University

印第安纳大学阿尔茨海默病和 ADRD 培训补助金

• 批准号: 10393637
• 负责人: GARY E. LANDRETH
• 金额: $ 49.45万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393637
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Grant; Indiana; Training; Universities

The overall goal of the program is to provide multidisciplinary training in Alzheimer’s disease and AD-related dementias (AD/ADRD) to predoctoral and postdoctoral trainees, producing a critically-needed translational workforce for developing effective treatments. The Indiana University School of Medicine (IUSM) is nationally recognized for AD/ADRD research. IUSM-associated centers include the Indiana Alzheimer’s Disease Research Center, the National Cell Repository for Alzheimer’s Disease, the Indiana Center for Neuroimaging, the Regenstrief Institute and the Center for Aging Research. Importantly, the NIA recently funded the MODEL-AD Center, the Alzheimer’s Disease Drug Discovery Center, and the IUSM-directed Longitudinal Early-Onset Alzheimer’s Disease Study. IUSM has invested significantly in state-of-the-art facilities, instrumentation, and the hiring of 10 new AD/ADRD faculty over the past 4 years. This T32 application has enlisted 25 participating faculty with a broad range of expertise including data science, non-invasive imaging, the development and study of animal models, genomics, epidemiology, drug development and discovery, and clinical studies and trials. These faculty are exceptional mentors and are funded at $42M total ($1.69M/faculty annually). This application requests funding for 4 pre- and 4 post-doctoral trainees. We will recruit trainees with diverse backgrounds and train them in AD/ADRD research with contemporary approaches and methodologies using state-of-the-art instrumentation. The predoctoral trainees are graduate students in the Medical Neuroscience Graduate Program, recruited from the IUSM Indiana Biomedical Gateway graduate program and the MD/PhD program. Targeted recruiting of postdoctoral trainees with diverse backgrounds is achieved informally, through our website, and at national and regional meetings. Enrollment in the MedNeuro Graduate Program has doubled since 2017 and the number of postdoctoral fellows with participating faculty has increased from 4 to 27. The predoctoral training program consists of foundational course work in neuroscience, neurodegenerative diseases, and data science along with elective studies. Postdoctoral trainees are offered didactic training in data science. The NIA-sponsored centers and resources at IUSM allow trainees to work on new disease models, advanced drug-discovery technologies, and in clinical settings. This positions trainees to conduct innovative basic, translational, and clinical AD/ADRD research.

该计划的总体目标是在阿尔茨海默氏症中提供多学科培训 疾病和与广告相关的痴呆症（AD/ADRD） 生产急需的翻译员工队伍，以开发有效的治疗方法。这 印第安纳大学医学院（IUSM）因广告/ADRD研究而受到全国认可。 IUSM相关的中心包括印第安纳州阿尔茨海默氏病研究中心， 阿尔茨海默氏病的国家细胞存储库，印第安纳州神经影像中心， 雷恩斯特里夫研究所和老化研究中心。重要的是，NIA最近资助了 AD型中心，阿尔茨海默氏病药物发现中心和IUSM定向 纵向早期发作的阿尔茨海默氏病研究。 IUSM已在最先进的设施，工具和 在过去的4年中，雇用10个新的广告/ADRD教师。该T32申请已入伍25 参与具有广泛专业知识的教师，包括数据科学，无创的 动物模型，基因组学，流行病学，药物的成像，发展和研究 开发和发现以及临床研究和试验。这些教师很出色 导师，总计为4200万美元（每年16.9万美元/教师）。 该申请要求为4位前和4名博士后学员提供资金。我们将招募 具有潜水员背景的学员，并与当代的广告/ADRD研究一起培训 使用最先进的仪器的方法和方法。托管前学员 是从IUSM招募的医学神经科学研究生课程的研究生 印第安纳州生物医学网关研究生计划和MD/PhD计划。有针对性的招聘 通过我们的网站，非正式地实现了具有潜水员背景的博士后学员的 以及在国家和地区会议上。 Medneuro研究生课程的注册 自2017年以来翻了一番，与参加教师的博士后研究员数量 从4增加到27。 专业培训计划包括神经科学的基础课程， 神经退行性疾病和数据科学以及选修研究。博士后学员 在数据科学方面提供了教学培训。 IUSM的NIA赞助中心和资源使学员可以从事新的工作 疾病模型，晚期药物发现技术和临床环境。这个位置 学员进行创新的基础，翻译和临床广告/ADRD研究。