Tuberculosis & HIV Co-Infection Training Program in Kenya

结核

• 批准号: 10392506
• 负责人: Thomas R Hawn
• 金额: $ 28.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10392506
• 关键词: Address; Bacillus; Biometry; Cause of Death; Childhood; Collaborations; Country; Coupled; Educational workshop; Epidemic; Epidemiology; Fellowship; Goals; HIV; HIV Infections; HIV/TB; Health; Infection prevention; Kenya; Laboratories; Leprosy; Lung diseases; Medical Research; Mentors; Mycobacterium tuberculosis; Pediatric Research; Persons; Pharmaceutical Preparations; Pharmacotherapy; Public Health; Recording of previous events; Research; Research Institute; Research Personnel; Research Project Grants; Scientist; Training; Training Programs; Treatment Protocols; Tuberculosis; Universities; Vaccines; Washington; Work; co-infection; combat; doctoral student; interest; macrophage; next generation; novel; programs; supportive environment; training opportunity

Abstract Tuberculosis (TB) is the leading cause of death in people living with HIV infection (PLHIV). Despite the discovery of Mycobacterium tuberculosis (Mtb) over 100 years ago and the availability of effective drugs for over 60 years, there remain formidable hurdles for controlling TB including the lack of a highly efficacious vaccine, long drug treatment regimens, prevention of infection, and killing dormant bacilli within macrophages. To address these problems, novel research and public health strategies need to be developed and coupled with enhanced training and local capacity building in high TB endemic countries. Kenya is one of 30 TB high burden countries which together constitute over 80% of global TB cases. The University of Nairobi (UoN), the Kenya Medical Research Institute (KEMRI) and the University of Washington (UW) propose a new TB-HIV Training Program (TBHTP) to address these needs. The TBHTP includes close partnerships in Kenya with the Ministry of Health National Tuberculosis Leprosy and Lung Disease Program (MoH NTLP), and the Kenya Pediatric Research Consortium (KEPRECON) – the research organization affiliated with the Kenya Pediatric Association (KPA). The primary goal of our program is to collaboratively develop training opportunities to address local needs in training and research capacity building. This partnership builds on a 35- year history of collaboration and training in HIV research between UW, KEMRI, and UoN. Although this partnership has been highly successful, TB has not been a high priority or focused goal of previous efforts. To build the capacity of KEMRI and the University of Nairobi (UoN) to conduct TB and TB-HIV co-infection research, we propose to implement a long-term training degree-earning track, a medium-term training non- degree track, and a short-term training track. During the 5-year period, we will train 5 UW MPH, 5 UoN Fellowship in Epidemiology, and 5 UoN PhD students working at KEMRI, UoN, or the MoH. We will also train 10 medium term non-degree scientists who have interest and potential in TB research will attend UW and take coursework in epidemiology and biostatistics or work in a laboratory for one to three months before returning to Kenya and engaging in a mentored research project. Finally, we will conduct short term workshops and provide on-line courses to build a critical mass of trained researchers who will create a supportive environment for research in TB. Together, these training opportunities will enhance local capacity and train the next generation of leaders who will discover novel research and public health strategies to combat the TB epidemic in Kenya.

抽象的 结核病（TB）是艾滋病毒感染患者（PLHIV）死亡的主要原因。尽管有 在100年前发现结核分枝杆菌（MTB），并有效的药物可用于 在60多年来，仍存在控制结核病的巨大障碍，包括缺乏高效 疫苗，长期药物治疗方案，预防感染和杀死巨噬细胞中休眠的细菌。 为了解决这些问题，需要制定并结合新颖的研究和公共卫生策略 在高结核病基因体国家中，通过增强的培训和本地能力建设。肯尼亚是30汤匙高高之一 伯宁国家共同占全球结核病案件的80％以上。内罗毕大学（UON）， 肯尼亚医学研究所（KEMRI）和华盛顿大学（UW）提出了新的 TB-HIV培训计划（TBHTP）以满足这些需求。 TBHTP包括密切合作伙伴关系 肯尼亚与卫生部国家结核病麻风病和肺部疾病计划（MOH NTLP）和 肯尼亚儿科研究联盟（Keprecon） - 肯尼亚的研究组织 小儿协会（KPA）。我们计划的主要目标是协作开发培训 解决培训和研究能力建设中当地需求的机会。这种伙伴关系建立在35- UW，Kemri和UON之间的艾滋病毒研究合作与培训的年度历史。虽然这个 合作伙伴关系非常成功，结核病并不是先前努力的高优先事项或重点目标。到 建立Kemri和内罗毕大学（UON）进行结核病和TB-HIV共同感染的能力 研究，我们建议实施长期培训学位培训轨道，一种中期培训非 - 学位轨道和短期培训轨道。在5年期间，我们将训练5个UW MPH，5 UON 流行病学研究金，以及在Kemri，Uon或MOH工作的5名UON博士学位学生。我们还将训练 在TB研究中具有有趣且潜力的10个中学期非学位科学家将参加UW并参加 流行病学和生物统计学课程或在实验室工作一到三个月，然后才返回 肯尼亚并参与研究项目。最后，我们将进行短期研讨会，并提供 在线课程建立大量受过训练的研究人员，他们将为 结核病研究。这些培训机会将共同提高当地能力并培训下一个 一系列领导者将发现新颖的研究和公共卫生策略来对抗结核病 肯尼亚流行病。