Radiographic markers of clinical function in Cervical Spondylotic Myelopathy

脊髓型颈椎病临床功能的放射学标志物

• 批准号: 10395736
• 负责人: Zachary A Smith
• 金额: $ 17.82万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10395736
• 关键词: Aftercare; Age; Anatomy; Biological Markers; Biomechanics; Cervical; Cervical spine; Clinical; Degenerative Disorder; Diagnostic radiologic examination; Disease; Goals; Head; Image; Injury; Magnetic Resonance Imaging; Neuromechanics; Operative Surgical Procedures; Pain; Patients; Posture; Process; Prognosis; Recovery; Research Proposals; Roentgen Rays; Role; Spinal; Spinal Cord Diseases; Spinal Diseases; Spinal Injuries; Standardization; Testing; Work; aging population; clinically relevant; disability; improved

Project Summary Cervical spondylotic myelopathy (CSM) is a common degenerative condition of the cervical spine that leads to pain and progressive spinal injury. Primary drivers of clinical injury in CSM include forward head posture (a biomechanical process) and spinal compression (a neuromechanical process). The current proposal seeks to define clinically-relevant radiographic biomarkers, using standard X-ray and Magnetization Transfer-MRI images, to investigate the role of head posture and spinal compression in CSM patients and age-matched controls. These biomarkers will then be directly correlated to anatomically-specific tests of clinical function, including pain, disability, strength, and coordination. The long-term goal is to develop standardized radiographic values and thresholds that can be used to identify appropriate surgical candidates and predict prognosis.

项目概要 脊髓型颈椎病 (CSM) 是一种常见的颈椎退行性疾病，可导致 疼痛和进行性脊柱损伤。 CSM 临床损伤的主要驱动因素包括头部前倾姿势（a 生物力学过程）和脊柱压缩（神经力学过程）。目前的提案旨在 使用标准 X 射线和磁化转移 MRI 定义临床相关的放射线生物标志物 图像，研究 CSM 患者和年龄匹配的头部姿势和脊柱受压的作用 控制。然后，这些生物标志物将与临床功能的解剖学特异性测试直接相关， 包括疼痛、残疾、力量和协调性。长期目标是发展标准化 放射照相值和阈值可用于识别合适的手术候选者并预测 预后。

项目成果

Degenerative cervical myelopathy: establishing severity thresholds for neuromotor dysfunction in the aging spine using the NIH Toolbox Assessment Scale.

退行性脊髓型颈椎病：使用 NIH 工具箱评估量表建立老化脊柱神经运动功能障碍的严重阈值。

• DOI: 10.1007/s11357-023-00983-3
• 发表时间: 2024
• 期刊: GeroScience
• 影响因子: 5.6
• 作者: Muhammad,Fauziyya;Hameed,Sanaa;Haynes,Grace;Mohammadi,Esmaeil;Khan,AliF;Shakir,Hakeem;Smith,ZacharyA
• 通讯作者: Smith,ZacharyA

Utility of MRI in Quantifying Tissue Injury in Cervical Spondylotic Myelopathy.

• DOI: 10.3390/jcm12093337
• 发表时间: 2023-05-08
• 期刊: JOURNAL OF CLINICAL MEDICINE
• 影响因子: 3.9
• 作者: Khan, Ali Fahim;Haynes, Grace;Mohammadi, Esmaeil;Muhammad, Fauziyya;Hameed, Sanaa;Smith, Zachary A. A.
• 通讯作者: Smith, Zachary A. A.