Radiographic markers of clinical function in Cervical Spondylotic Myelopathy

脊髓型颈椎病临床功能的放射学标志物

• 批准号: 10194621
• 负责人: Zachary A Smith
• 金额: $ 17.91万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10194621
• 关键词: Aftercare; Age; Algorithms; Anatomy; Anterior; Area; Biological Markers; Biomechanics; Cervical; Cervical spine; Clinical; Complex; Data; Degenerative Disorder; Demyelinations; Descending Spinal Cord Tract; Diagnosis; Diagnostic radiologic examination; Disease; Fatty acid glycerol esters; Functional disorder; Gender; Goals; Head; Image; Individual; Injury; Intervention; Laboratories; Length; Magnetic Resonance Imaging; Measurement; Measures; Medical Care Costs; Methods; Motor; Muscle; Muscle Fatigue; Neck; Nervous System Physiology; Nervous System Trauma; Neuromechanics; Neuronal Injury; Neurons; Normal Range; Operative Surgical Procedures; Outcome; Pain; Patients; Pattern; Population; Posture; Process; Prognosis; Proprioception; Recovery; Research Proposals; Resolution; Roentgen Rays; Role; SF-36; Sensory; Skeletal muscle structure of neck; Spinal; Spinal Cord; Spinal Cord Diseases; Spinal Diseases; Spinal Injuries; Spinal cord injury; Standardization; Surface; Symptoms; Testing; Training; United States National Institutes of Health; Upper Extremity; Vertebral column; Work; aged; aging population; base; chronic pain; clinical pain; clinically relevant; disability; improved; indexing; negative affect; nerve injury; operation; pain score; patient population; postoperative recovery; research clinical testing; skill acquisition; spasticity; spinal cord compression; spinal pathway; spinal tract; statistics; white matter

Project Summary Cervical spondylotic myelopathy (CSM) is a common degenerative condition of the cervical spine that leads to pain and progressive spinal injury. Primary drivers of clinical injury in CSM include forward head posture (a biomechanical process) and spinal compression (a neuromechanical process). The current proposal seeks to define clinically-relevant radiographic biomarkers, using standard X-ray and Magnetization Transfer-MRI images, to investigate the role of head posture and spinal compression in CSM patients and age-matched controls. These biomarkers will then be directly correlated to anatomically-specific tests of clinical function, including pain, disability, strength, and coordination. The long-term goal is to develop standardized radiographic values and thresholds that can be used to identify appropriate surgical candidates and predict prognosis.

项目摘要 颈脊椎脊髓病（CSM）是颈椎的常见退化疾病，导致 疼痛和进行性脊柱损伤。 CSM临床损伤的主要驱动因素包括前头姿势（a 生物力学过程）和脊柱压缩（神经力学过程）。当前的提议试图 使用标准的X射线和磁化转移MRI定义临床上与临床相关的X线照相生物标志物 图像，研究CSM患者中头部姿势和脊柱压缩的作用并匹配年龄 控件。然后，这些生物标志物将与临床功能的解剖学特异性测试直接相关， 包括疼痛，残疾，力量和协调。长期目标是开发标准化 可用于识别适当手术候选者并预测的射线照相值和阈值 预后。