Regional Biocontainment Laboratory (RBL) Upgrade for Colorado State University (CSU)

科罗拉多州立大学 (CSU) 区域生物防护实验室 (RBL) 升级

• 批准号: 10393892
• 负责人: Karen Marie Dobos
• 金额: $ 330万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393892
• 关键词: 2019-nCoV; Address; Aging; Basic Science; Certification; Charge; Colorado; Communicable Diseases; Communities; Containment; Coupled; Diagnostic Reagent; Disease; Disease Outbreaks; Emerging Communicable Diseases; Environment; Equipment; Extramural Activities; Funding; Health care facility; Home; Infectious Diseases Research; Investments; Laboratories; Middle East Respiratory Syndrome Coronavirus; Modernization; Process; Readiness; Research; Research Personnel; Risk; Safety; Services; System; Testing; Therapeutic; Time; Tuberculosis; Universities; Vaccines; ZIKA; animal care; biodefense; cost; emerging pathogen; pathogen; public health emergency; repaired; response; success; 2019-nCoV; Address; Aging; Basic Science; Certification; Charge; Colorado; Communicable Diseases; Communities; Containment; Coupled; Diagnostic Reagent; Disease; Disease Outbreaks; Emerging Communicable Diseases; Environment; Equipment; Extramural Activities; Funding; Health care facility; Home; Infectious Diseases Research; Investments; Laboratories; Middle East Respiratory Syndrome Coronavirus; Modernization; Process; Readiness; Research; Research Personnel; Risk; Safety; Services; System; Testing; Therapeutic; Time; Tuberculosis; Universities; Vaccines; ZIKA; animal care; biodefense; cost; emerging pathogen; pathogen; public health emergency; repaired; response; success

Project Abstract: The realization that our national and global communities are at risk from intentional, incidental, or emergent release of an infectious disease catalyzed our nation's commitment to invest in national and regional biocontainment laboratories as part of our public health and emergency preparedness system. The foothills campus at Colorado State University is home to one of these regional biocontainment laboratories, the Rocky Mountain Regional Biocontainment Laboratory (RMRBL). This laboratory was built in 2007, opened in 2008, and was the first of 12 designated laboratories to operate with select agent use certification. In the 14 years since its opening, our facility has thrived as a center of biodefense and emerging infectious disease research, responding to threats from re-emergent diseases, such as tuberculosis, and emerging infectious diseases, such as Middle East Respiratory Syndrome coronavirus, Zika, and notably, Severe Acute Respiratory Syndrome Coronavirus 2. This facility is truly unique in its capacity as it supports BSL3/ASBL3 and BSL2 basic research of a large number of emerging and re-emerging pathogens, and at the same time, supports the GLP/GMP testing and manufacturing of products (diagnostic reagents, vaccines, and therapeutics) in a BSL3 environment. Despite the RMRBL's success and strengths, a sole reliance on institutional commitment and service charges to investigators to support the costs of 1) operational and safety requirements of the facility; 2) animal care facilities and husbandry dedicated to infectious diseases; and 3) specialized equipment upgrades and repairs, present a major challenge to this facility's ability to remain at the forefront of research in pathogens of high consequence. The proactive and professional management of the RMRBL, and strong extramural funding of infectious diseases research at Colorado State University have allowed us to navigate these challenges; however, the continued aging of the facility coupled with the major costs of modernization and major facility and specialized equipment upgrades threaten the sustainability of the RMRBLs capacity to support state-of-the-art infectious disease research. In this application, we propose three aims that respectively address the needs to 1) upgrade operational and safety requirements of the facility, 2) maintain animal care facilities and husbandry dedicated to infectious diseases, and 3) modernize specialized equipment via strategic investments. The specific items selected under each aim as a critical investment were selected via a prioritization process that sought input from the major RMRBL and institutional stake holders and were determined to have the greatest impact on uninterrupted and accelerated research on high-containment pathogens and response to infectious disease outbreaks.

项目摘要： 意识到，我们的民族和全球社区受到故意，附带或 紧急释放一种传染病促进了我们国家投资国民的承诺 作为我们公共卫生和紧急紧急情况的一部分，区域生物疗法实验室 准备系统。科罗拉多州立大学的Foothills校园是其中之一 落基山地区生物培养业实验室区域生物疗养实验室 （rmrbl）。该实验室建于2007年，于2008年开业，是指定的12个 实验室使用Select Agent使用认证。自开业以来的14年中，我们 设施已成为生物化和新兴传染病研究的中心， 应对重新出现疾病的威胁，例如结核病和新兴的感染力 疾病，例如中东呼吸综合征冠状病毒，寨卡病毒，尤其是严重 急性呼吸综合症冠状病毒2。该设施的能力确实是独一无二的 支持大量新兴和重新出现的BSL3/ASBL3和BSL2基础研究 病原体以及同时支持GLP/GMP测试和制造产品 （诊断试剂，疫苗和治疗剂）在BSL3环境中。尽管有RMRBL的 成功和优势，唯一依赖机构承诺和服务费用 调查人员支持1）设施的运营和安全要求； 2） 动物护理设施和致力于传染病的饲养； 3）专业 设备升级和维修，对该设施保持在该设施的能力提出了重大挑战 高后果病原体研究的最前沿。积极主动 RMRBL的管理以及在 科罗拉多州立大学允许我们应对这些挑战。但是，继续 该设施的老化以及现代化和主要设施的主要成本以及 专业设备升级威胁了RMRBLS支持能力的可持续性 最先进的传染病研究。在此应用程序中，我们提出了三个目标 分别满足需要1）升级设施的操作和安全要求， 2）维护动物护理设施和致力于传染病的饲养，以及3） 通过战略投资对专业设备进行现代化。选择的特定项目 每个目标都是通过优先级的过程选择的，该过程寻求从 主要的RMRBL和机构股权持有人，并决心具有最大的影响 关于对高传输病原体的不间断和加速研究以及对 传染病暴发。