Research Resources and Workforce Development for the Rocky Mountain Regional Biocontainment Laboratory at Colorado State University

科罗拉多州立大学落基山区域生物防护实验室的研究资源和劳动力发展

• 批准号: 10793907
• 负责人: Karen Marie Dobos
• 金额: $ 275.15万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793907
• 关键词: 2019-nCoV; Acceleration; Address; Adult; American; Animal Husbandry; Biocompatible Materials; Bioterrorism; COVID-19; Cells; Chronic; Climate; Collaborations; Colorado; Communicable Diseases; Communication; Competence; Dedications; Development; Diagnostic; Disease; Domestic Animals; Education; Educational process of instructing; Educational workshop; Emergency Situation; Emerging Communicable Diseases; Ensure; Environment; Equipment; Event; Evolution; Face; Fellowship; Foundations; Funding; Goals; Grant; Health system; In Vitro; Infection; Infectious Agent; Information Technology; Infrastructure; Investments; Laboratories; Lead; Learning; Maintenance; Mission; Modeling; Modernization; Monkeypox; Monoclonal Antibodies; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Operations Research; Pathogenicity; Performance; Persons; Procedures; Public Health; Qualifying; Reagent; Research; Research Personnel; Research Support; Resource Development; Resources; Rodent; Safety; Scholars Program; Secure; Security; Services; Structure; System; Talents; Technology; Therapeutic; Toxin; Training; Training Programs; Training and Education; Translating; Tuberculosis; Universities; Vaccines; Vision; Work; Workforce Development; Zoonoses; aged; base; biodefense; biosafety level 3 facility; biosecurity; combat; coronavirus disease; design; improved; in vivo; industry partner; innovation; instrument; laboratory facility; mass spectrometric imaging; molecular mass; operation; outreach; pandemic disease; pandemic pathogen; pandemic potential; pathogen; professional atmosphere; programs; recruit; research facility; response; spillover event; success; symposium; usability; vaccine development; visiting scholar

Project Summary: The Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University (CSU) has been responsive to the national RBL mission to: 1) “Conduct research on biodefense and emerging infectious disease agents”; 2) “Be available and prepared to assist national, state, and local public health efforts in the event of a bioterrorism or infectious disease emergency” since its opening and full commissioning in 2008. Researchers at the RMRBL and their collaborators rapidly pivoted in response to the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), working on host-derived therapeutics, vaccines, and identifying other potential zoonotic reservoirs as spillover opportunities in wildlife and domestic animals. Our researchers similarly pivoted this past year to work on countermeasures in response to the re-emergence of Mpox, while also continuing to address high consequence pathogens that have chronically plagued public health systems, such as Mycobacterium tuberculosis, the causative agent of Tuberculosis. Beyond our demonstrated ability to rapidly address research and research service needs on pathogens with pandemic potential, our team contributes to training, outreach, and access of our facility via sponsored fellowships, visiting scholars’ programs, workshops, conferences, and through collaborations. Despite these gains, our RMRBL BSL3 suites are aged, requiring constant investments to maintain safe, secure and compliant BSL3 facilities. RMRBL BSL3 researchers, support staff, and biosafety professionals are vulnerable to the strain of the work environment, limited resources, funding gaps, and opportunities to engage in less risky fields equipped with cutting edge technologies. In this application, we respond to the challenges facing the RMRBL BSL3 laboratories with 3 Cores. Core 1 includes an improved management structure, systematic replacement of deprecating scientific instruments, and comprehensive and proactive maintenance of existing facilities needs to ensure compliance and continuous functioning. Operation of the RMRBL BSL3 is additionally enhanced to improve the working environment and increase consistency for operations research support and animal husbandry staff. Core 2’s initiatives seek to develop training programs responsive to adult learning and education best practices, ensuring improved safety and safety compliance in persons working in the BSL3. Biosecurity upgrades will improve the safety and security climate in anticipation of new national standards, and integration between research teams and the office of Biosafety in constructing and training in technical standard operating procedures will accelerate safe performance and technical competence. Finally, Core 3 synthesizes our research strengths to develop a uniquely qualified Biocontainment Research Resources Core, bringing together opportunities to exploit team talent and perform innovative research. Combined, our three Cores ensure that the RMRBL BSL3 facilities are always ‘warm ready’ – to face and combat the next pathogenic pandemic threat.

项目摘要：科罗拉多州落基山地区生物防护实验室 (RMRBL) 大学 (CSU) 一直响应国家 RBL 使命：1)“开展生物防御和生物防御研究” 2) “随时准备好协助国家、州和地方公众 自其开业和全面启动以来，在发生生物恐怖主义或传染病紧急情况时的卫生努力” 2008 年投入使用。RMRBL 的研究人员及其合作者迅速转向以应对 严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 的出现，作用于宿主来源 治疗方法、疫苗以及确定其他潜在的人畜共患病宿主作为野生动物的溢出机会 我们的研究人员去年也同样致力于研究应对措施。 应对 Mpox 的重新出现，同时继续解决造成严重后果的病原体 长期困扰公共卫生系统，例如结核分枝杆菌，它是结核病的病原体 超越我们所证明的快速满足研究和研究服务需求的能力。 具有大流行潜力的病原体，我们的团队通过以下方式为培训、外展和进入我们的设施做出贡献 赞助奖学金、访问学者项目、研讨会、会议以及合作。 尽管取得了这些成就，我们的 RMRBL BSL3 套件已经过时，需要不断的投资来维护安全、 安全且合规的 BSL3 设施是 RMRBL BSL3 研究人员、支持人员和生物安全专业人员。 容易受到工作环境压力、资源有限、资金缺口和参与机会的影响 在配备尖端技术的风险较小的领域，我们应对挑战。 面对具有 3 个核心的 RMRBL BSL3 实验室，核心 1 包括改进的管理结构， 系统地更换报废的科学仪器，并进行全面主动的维护 现有设施需要确保 RMRBL BSL3 的合规性和持续运行。 进一步增强以改善工作环境并提高运筹学的一致性 Core 2 的举措旨在制定适合成人的培训计划。 学习和教育最佳实践，提高安全和安全合规性，确保工作人员 BSL3 升级将改善新国家的安全和安保氛围。 标准以及研究团队和生物安全办公室在建设和培训方面的整合 最后，技术标准操作程序将提高安全性能和技术能力。 Core 3 综合了我们的研究优势，开发了独特且合格的生物防护研究 资源核心，汇集了开发团队人才和进行创新研究的机会。 我们的三个核心相结合，确保 RMRBL BSL3 设施始终处于“准备就绪”状态 – 面对和 对抗下一次致病性大流行威胁。