2022 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference and Seminar

2022年纤溶酶原激活和细胞外蛋白水解戈登研究会议暨研讨会

基本信息

批准号：
10386008
负责人：
MATTHEW J FLICK
金额：
$ 2.3万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-20 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10386008
关键词：
Achievement Aging Alteplase Area Basic Science Biology Blood Circulation Blood Vessels Cardiovascular Diseases Cardiovascular Physiology Cerebrovascular Disorders Clinic Clinical Clinical Research Coagulation Process Collaborations Communicable Diseases Communities Data Development Diagnosis Disease Educational process of instructing Ensure Environment Fostering Functional disorder Funding Goals Growth Hematopoiesis Holidays Homeostasis Immunity Individual Infection International Ischemic Stroke Knowledge Lead Location Malignant Neoplasms Matrix Metalloproteinases Metabolic Diseases Metabolism Musculoskeletal Diseases Natural regeneration Nervous System Physiology Neuraxis Neurodegenerative Disorders Obesity Organ Participant Pathologic Pathologic Processes Pathway interactions Peptide Hydrolases Persons Physicians Physiological Processes Plasmin Plasminogen Plasminogen Activator Play Postdoctoral Fellow Prevention Process Proteins Proteolysis Recombinants Research Research Personnel Role Scientist Stroke System Therapeutic Tissues Translating Trauma Tumor Biology Underrepresented Populations Woman Women&apos s Group Work angiogenesis career cerebrovascular clinically relevant expectation experience extracellular frontier graduate student human disease improved inhibitor meetings mid-career faculty nervous system disorder new technology novel strategies peer peer networks pre-doctoral recruit stem cell biology symposium therapeutic target

项目摘要

Summary Partial support is requested for graduate students and post-doctoral fellows, and junior and midcareer faculty to participate in the Gordon Research Seminar and Conference (GRS/GRC) entitled “Plasminogen Activation and Extracellular proteolysis”, which will be held in Ventura, CA on February 5-6 and 6-11, 2022, respectively. This will be the 18th GRC, as the conference has been held continuously every two years since 1990. The focus of the 2022 GRC will be on mechanisms and therapeutic targets of extracellular proteolytic enzymes, including plasmin(ogen), plasminogen activators, coagulation proteases, matrix-metalloproteinases (MMPs), their precursors, inhibitors, and effectors. Recent data suggest that the expression of proteases in circulation and the extravascular compartments of tissues is tied to numerous pathological processes. Our invited speakers and discussion leaders will present their recent and emerging work across a spectrum of basic science and clinical topics, including cardiovascular disease, aging, cerebrovascular function, metabolic diseases, musculoskeletal and neurodegenerative diseases, cancer, infection and immunity, tissue remodeling and regeneration, as well as trauma. Priority will be placed on highlighting both the role these proteins play as disease modifiers as well the utility of employing or targeting these factors for diagnosis and therapy. One of the major goals for the 2022 GRC meeting is translating basic research into the clinic. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of research, with a strong emphasis on equity of opportunity and inclusion of individuals across all demographic metrics. Additional efforts will be committed to recruit women and scientists of underrepresented groups as session leaders and speakers for both the GRS and GRC. Indeed, an intended strength of this meeting will be the interaction and networking of the young scientists in the field, with the discussion leaders and the speakers. The associated GRS, which is a younger feature of the conference, will provide a unique opportunity for trainees and beginning scientists to present their research and share the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers and the GRC Chairs, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current unpublished research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.

概括要求为研究生和博士后研究员提供部分支持，以及初级和中级教师参加戈登研究研讨会和会议（GRS/GRC）的标题为“纤溶酶原激活和细胞外蛋白水解”，将分别于2022年2月5日至6日和6-11在加利福尼亚州的文图拉举行。这将是第18个GRC，因为自1990年以来，一次会议每两年一次举行一次。 2022 GRC的重点将放在细胞外蛋白水解酶的机制和治疗靶标上包括纤溶酶（OGEN），纤溶酶原活化剂，凝结蛋白酶，基质 - 绝素蛋白酶（MMP），它们的前体，抑制剂和效果。最近的数据表明蛋白酶在循环中的表达组织的血管外室与许多病理过程有关。我们的邀请演讲者和讨论负责人将介绍他们最近的新兴工作科学和临床主题，包括心血管疾病，衰老，脑血管功能，代谢疾病，肌肉骨骼和神经退行性疾病，癌症，感染和免疫学，组织重塑和再生以及创伤。优先考虑这些蛋白质扮演的角色疾病修饰符以及将这些因素用于诊断和治疗的实用性。之一 2022年GRC会议的主要目标是将基础研究转化为诊所。与会者会根据邀请和在线提交的申请中选择。他们将被选为代表潜水员研究范围，非常强调机会平等和个人包容所有人人口指标。将努力招募妇女和代表性不足的科学家小组作为GRS和GRC的会议负责人和演讲者。确实，这是一个预期的优势会议将是该领域年轻科学家的互动和网络，与讨论领导者和演讲者。相关的GRS是会议的年轻特征，将提供独特的受训者的机会并开始科学家展示他们的研究并分享GRC的经验。这两天的开创性将由研究生和博士后研究员组织研究人员和GRC椅子，将允许纤溶酶原活化领域的初级研究人员和细胞外蛋白水解聚集在一起，讨论他们当前未发表的研究，同时建立与同行的非正式网络可能会导致一生的合作和科学成就。