Translational Genomics and Precision Medicine in Cancer Training Program

癌症转化基因组学和精准医学培训计划

• 批准号: 10380570
• 负责人: ANN M KILLARY
• 金额: $ 25.57万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380570
• 关键词: Genomic medicine; Malignant Neoplasms; Training Programs; precision medicine; translational genomics

PROJECT SUMMARY There is a critical need to train the next generation of translational cancer researchers in light of a new era of genomic medicine and big data. We must ensure that scientists are trained in the areas of highest need for translation of data and experiments into clinical practice. This proposal builds on an existing interdisciplinary education and research training program developed at MD Anderson Cancer Center, where we have a single mission to eliminate cancer, in order to expand and enhance the training of outstanding predoctoral and postdoctoral fellows using an innovative curriculum and multidisciplinary approach centered on core competencies in state-of-the-art areas of translational research. Objectives: 1) to provide a comprehensive program with both depth and breadth in areas important to the future of translational cancer research including translational genomics and precision medicine approaches, early detection and prognosis of cancer, as well as diagnostic applications; 2) to recruit top predoctoral and postdoctoral fellows interested in a career in translational cancer research in this area; 3) to provide fellows with an innovative environment, infrastructure, faculty and administrative support to allow them to make significant contributions to the field and further the mission of the MD Anderson Cancer Center. Rationale: Translational Genomics and Precision Medicine in Cancer (TGP) Training Program: The TGP program will provide the necessary education and training as well as infrastructure and oversight to develop innovative, big data genome scientists. A highly competitive selection process will identify outstanding candidates and ensure diversity in the process. Qualified candidates, in addition to a mentored research experience by one of our outstanding training grant faculty, will gain individualized, interdisciplinary training in core competency areas critical to the future of translational science in a postgenome world. Design of T32 Program: The T32 will offer 3 postdoctoral and 1 predoctoral fellowships designed around core competencies which include: 1) translational cancer research, to gain exposure to mechanistic studies in translational research and their importance to the human organism; 2) precision medicine to gain experience in state-of-the-art approaches to diagnose and treat cancer patients; 3) translational genetics and genomics to gain competency in understanding and implementation of cancer precision medicine; 4) bioinformatics, to learn how to read and interpret large datasets; and 5) exposure to clinical grand rounds, tumor boards, and industrial collaborations. Key activities include: grant writing workshops, NIH grant development, and focused mentoring. All trainees will be required to have strong interest in cancer research and for postdoctorates, experience in cancer research. Training duration will be 2 years for postdoctoral and up to 3 years for predoctoral fellows with training faculty associated with UT MD Anderson Cancer Center and with the UT Graduate School of Biomedical Sciences.

项目概要 鉴于新时代，迫切需要培训下一代转化癌症研究人员 基因组医学和大数据。我们必须确保科学家在最需要的领域接受培训 将数据和实验转化为临床实践。该提案建立在现有的跨学科 MD 安德森癌症中心开发的教育和研究培训计划，我们有一个单一的 以消灭癌症为己任，扩大和加强优秀博士前和博士生培养 博士后研究员使用以核心为中心的创新课程和多学科方法 最先进的转化研究领域的能力。 目标：1）在对未来重要的领域提供具有深度和广度的综合课程 转化癌症研究，包括转化基因组学和精准医学方法，早期 癌症的检测和预后以及诊断应用； 2）招募顶尖博士生和 对这一领域的转化癌症研究感兴趣的博士后研究员； 3）为研究员提供 创新的环境、基础设施、师资和行政支持，使他们能够取得重大成就 对该领域的贡献并进一步实现 MD 安德森癌症中心的使命。 基本原理：癌症转化基因组学和精准医学 (TGP) 培训计划：TGP 该计划将提供必要的教育和培训以及基础设施和监督，以发展 创新的大数据基因组科学家。竞争激烈的选拔过程将甄选出优秀的 候选人并确保过程中的多样性。合格的候选人，除了指导研究之外 我们一位杰出的培训资助教师的经验，将获得个性化、跨学科的培训 核心能力领域对于后基因组世界中转化科学的未来至关重要。 T32项目的设计：T32将提供围绕核心设计的3个博士后和1个博士前奖学金 能力包括：1）转化癌症研究，接触以下领域的机制研究： 转化研究及其对人体的重要性； 2）精准医疗，积累经验 诊断和治疗癌症患者的最先进方法； 3）转化遗传学和基因组学获得 理解和实施癌症精准医学的能力； 4）生物信息学，学习如何 读取和解释大型数据集； 5) 接触临床大查房、肿瘤委员会和工业 合作。主要活动包括：拨款写作研讨会、NIH 拨款开发和重点指导。 所有学员都需要对癌症研究有浓厚的兴趣，对于博士后来说，需要有以下方面的经验： 癌症研究。博士后培训期限为2年，博士前研究员培训期限最长为3年 与 UT MD 安德森癌症中心和 UT 生物医学研究生院相关的培训师资 科学。

项目成果

Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer.

• DOI: 10.2196/26601
• 发表时间: 2021-06-17
• 期刊: JMIR medical informatics
• 影响因子: 3.2
• 作者: Enriquez JS;Chu Y;Pudakalakatti S;Hsieh KL;Salmon D;Dutta P;Millward NZ;Lurie E;Millward S;McAllister F;Maitra A;Sen S;Killary A;Zhang J;Jiang X;Bhattacharya PK;Shams S
• 通讯作者: Shams S

Game of clones: Battles in the field of carcinogenesis.

• DOI: 10.1016/j.pharmthera.2022.108251
• 发表时间: 2022-09
• 期刊: PHARMACOLOGY & THERAPEUTICS
• 影响因子: 13.5
• 作者: Rahal, Zahraa;Sinjab, Ansam;Wistuba, Ignacio I.;Kadara, Humam
• 通讯作者: Kadara, Humam

Tumor suppressor DEAR1 regulates mammary epithelial cell fate and predicts early onset and metastasis in triple negative breast cancer.

• DOI: 10.1038/s41598-022-22417-4
• 发表时间: 2022-11-14
• 期刊: Scientific reports
• 影响因子: 4.6

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes.

• DOI: 10.1038/s41587-020-00795-2
• 发表时间: 2021-05
• 期刊: Nature biotechnology
• 影响因子: 46.9
• 作者: Gao R;Bai S;Henderson YC;Lin Y;Schalck A;Yan Y;Kumar T;Hu M;Sei E;Davis A;Wang F;Shaitelman SF;Wang JR;Chen K;Moulder S;Lai SY;Navin NE
• 通讯作者: Navin NE

Generation of An Endogenous FGFR2-BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells.

在胆管细胞中使用单质粒 CRISPR/Cas9 编辑生成内源 FGFR2-BICC1 基因融合/58 兆碱基倒置。

• DOI: 10.3390/ijms21072460
• 发表时间: 2020
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Reicher,Andreas;Harris,AntoneickaL;Prinz,Felix;Kiesslich,Tobias;Wei,Miaoyan;Öllinger,Rupert;Rad,Roland;Pichler,Martin;Kwong,LawrenceN
• 通讯作者: Kwong,LawrenceN