Training in Clinical and Epidemiological Research for Liberia (TRACER)

利比里亚临床和流行病学研究培训（TRACER）

• 批准号: 10376045
• 负责人: JEFFREY N MARTIN
• 金额: $ 23.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-10 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10376045
• 关键词: Acute; Applications Grants; Biometry; California; Clinical; Clinical Research; Collaborations; Communicable Diseases; Communities; Country; Doctor of Philosophy; Ebola; Ebola Hemorrhagic Fever; Educational process of instructing; Emerging Communicable Diseases; Enrollment; Environment; Epidemic; Epidemiology; Etiology; Fever; Funding; Goals; Healthcare; Home; Human Resources; Infectious Diseases Research; Infrastructure; Institutes; International; Liberia; Liberian; Malaria; Mentors; Mentorship; Needs Assessment; Public Health; Publications; Research; Research Design; Research Personnel; Research Training; San Francisco; Targeted Research; Technology; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vision; Writing; base; career; epidemiology study; experience; investigator training; low and middle-income countries; metagenomic sequencing; programs; research study; skills; success

Training in Clinical and Epidemiological Research (TRACER) in Liberia (2018 Fogarty D43 Global Infectious Disease Research Training Grant Application) ABSTRACT The University of California, San Francisco (UCSF), in collaboration with the National Public Health Institute of Liberia (NPHIL), the University of Liberia, and NIH/PREVAIL, proposes a research training program to provide aspiring young investigators in Liberia with comprehensive didactic, mentored, and experiential training in clinical and/or epidemiological research targeting the etiology of acute febrile illness (AFI), emerging infectious diseases (EID)/Ebola and malaria. Our overall goal is to develop a cadre of well-trained investigators who can become part of a sustainable, independent clinical/ epidemiological research and training enterprise in the region. The 2014-2016 Ebola epidemic highlighted the severe lack of health care infrastructure and human resources in the country; Liberia is the 8th poorest country in the world. Our specific aims, based on our experience in Liberia, the country’s main public health infectious disease priorities, and the results of a D71-funded needs assessment, are to: 1)Train selected Liberians in clinical/epidemiological research by enrolling them into the UCSF Master’s in Clinical Research (MCR) (N=2) and the PhD program in Epidemiology and Translational Science (N=1); 2) Support graduated trainees to pursue their research careers in Liberia, and to begin teaching others; 3) Promote research on EID/Ebola, acute febrile illness, and malaria, and advance UCSF-Liberian collaborative research; 4) Support and train more advanced Liberian investigators to become effective mentors, and to write grant applications. The MCR program has successfully developed skills of young investigators for the last 20 years, including trainees from lower and middle income countries, nearly 90% of whom have gone onto successful research careers. Both the MCR and PhD programs focus on providing fundamental and advanced skills in research study design and implementation, biostatistics, analysis, epidemiology, and publication and presentation of research. Our experience has demonstrated that success requires intensive mentorship and a supportive in-country environment with research opportunities when trainees return home. UCSF has a strong malaria and EID research community to support trainees and is using cutting-edge metagenomics sequencing technology to determine causes of AFI. We will also make use of the existing research environment and infrastructure at NIH/PREVAIL in Liberia, and at NPHIL. Our shared vision is for Liberia to ultimately develop its own internationally competitive high-quality training program in clinical research.

利比里亚的临床和流行病学研究（Tracer）培训 （2018 Fogarty D43全球传染病研究培训赠款应用程序） 抽象的 加利福尼亚大学旧金山大学（UCSF）与国家公众合作 利比里亚卫生研究所（NPHIL），利比里亚大学和NIH/PRIPAIL，提案 研究培训计划，为利比里亚有抱负的年轻调查员提供全面 教学，指导和经验丰富的临床和/或流行病学研究的培训 急性发热疾病（AFI）的病因，新兴的传染病（EID）/埃博拉病毒和疟疾。 我们的总体目标是培养培训良好的调查人员的干部，他们可以成为 该地区可持续的，独立的临床/流行病学研究和培训企业。 2014 - 2016年埃博拉病毒的流行强调了严重缺乏医疗保健基础设施和 该国的人力资源；利比里亚是世界上第八个最贫穷的国家。我们的具体 目的是根据我们在利比里亚的经验，该国主要的公共卫生传染病 优先事项以及D71资助的需求评估的结果是：1）火车选定的利比里亚人 在临床/流行病学研究中，通过将其招募到UCSF临床上 研究（MCR）（n = 2）和流行病学和转化科学的博士学位计划（n = 1）； 2）支持毕业生在利比里亚从事研究事业的支持，并开始教学 其他的; 3）促进对开斋节/埃博拉病毒，急性高热病和疟疾的研究，并进步 UCSF-Liberian合作研究； 4）支持和培训更先进的利比里亚人 调查人员成为有效的导师并撰写赠款申请。 MCR计划 在过去的20年中，已成功发展了年轻调查人员的技能，包括受训者 来自中低收入国家，几乎有90％的成功 研究事业。 MCR和博士学位课程都侧重于提供基本和 研究研究设计和实施，生物统计学，分析的高级技能， 流行病学以及研究的出版和介绍。我们的经验证明了 这一成功需要密集的精神制，并且需要一个支持的国内环境 学员回家时的研究机会。 UCSF患有强大的疟疾和开斋节 研究社区支持受训者，并正在使用尖端的宏基因组学测序 确定AFI原因的技术。我们还将利用现有的研究 NIH/利比里亚和NPHIL的环境和基础设施。我们共同的愿景是 利比里亚最终制定自己的国际竞争性高质量培训计划 在临床研究中。