Early life trauma and aging using a long-lived animal model

使用长寿动物模型研究早期生命创伤和衰老

• 批准号: 10369990
• 负责人: Daniella E. Chusyd
• 金额: $ 13.06万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-15 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10369990
• 关键词: Address; Adult; Age; Aging; Animal Model; Applications Grants; Area; Autoimmune Diseases; Award; Awareness; Behavior; Biological; Caring; Child; Childhood; Chronology; Cognition; Conflict (Psychology); Development; Diabetes Mellitus; Disease; Disease Progression; Disease susceptibility; Doctor of Philosophy; Dose; Early-life trauma; Education; Effectiveness; Elephants; Emotional; Endocrine system; Endocrinology; Environment; Ethics; Ethnic Origin; Excision; Exercise; Exposure to; Family; Family member; Food; Fostering; Genetic; Goals; Hand; Health; Heart Diseases; Human; Immune system; Individual; Intelligence; Interruption; Intervention; K-Series Research Career Programs; Lead; Learning; Life; Life Expectancy; Longevity; Malignant Neoplasms; Memory; Mentorship; Methods; Modeling; Morbidity - disease rate; Mothers; Natural experiment; Nervous system structure; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Orphan; Orphanages; Outcome; Parasites; Parents; Persons; Physiological; Population; Post-Traumatic Stress Disorders; Predisposition; Prevalence; Property; Public Health; Randomized; Research; Research Personnel; Risk; Sampling; Science; Scientist; Smoking; Socioeconomic Status; Source; Stroke; System; TP53 gene; Ticks; Time; Training; Training Activity; Trauma; Variant; Water; Work; Zambia; adverse childhood events; affiliative behavior; allostasis; allostatic load; antisocial behavior; behavioral health; biological adaptation to stress; career development; cognitive function; cognitive task; design; early life exposure; experience; experimental study; feasibility testing; healthy aging; improved; innovation; insight; inter-individual variation; life history; mortality; pilot test; psychobiology; psychologic; response; sex; skills; social; social health determinants; social learning; social norm; standard care; stressor; trait

PROJECT SUMMARY/ABSTRACT Training: My research over the past eight years has focused primarily on elephant endocrinology, health, and aging. The work has shown that there are many similarities between elephants and humans (e.g., morbidities, life history, socialness, emotional complexity), and that leveraging information gathered by studying elephants may improve human health and aging. The proposed K01 career development training plan builds on that experience but identifies three areas that require additional training: (1) develop expertise in psychobiology and behavior, (2) enhance skills in aging science and methods, and (3) build skills in designing and implementing randomized experiments. Accordingly, we propose intensive topical mentorship, focused coursework, and contextual learning through the proposed research. This K01 will provide protected time to receive the needed training to enhance my expertise in these three areas and will propel me to becoming an independent research scientist focusing on healthy aging. Research: People who have endured adverse childhood experiences (ACEs) have increased risk of developing physical and psychological diseases later in life. They are 1.6 to 2.4 times more likely to develop obesity, cancer, heart disease, stroke, and diabetes as adults, and life expectancy is reduced by up to 20 years. Understanding how ACEs lead to disease in adulthood is important for developing interventions to interrupt disease progression. The proposed K01 attempts to address this need through the following objectives: to demonstrate the value of using the elephant as a model for human aging, and elucidating how early-life trauma influences an individual’s biological and social trajectory. Like humans, calves are highly reliant and bonded to their mother, and can suffer post-traumatic stress disorder after witnessing her killing. The poaching of random elephants for their tusks has provided a natural experiment to compare highly traumatized orphaned elephants with non-orphaned elephants in regard to their allostatic load, biological age, cognition, and disease susceptibility. This will be the first study that we are aware of that uses the elephant to understand the implications of early-life trauma, while also implementing a randomized experiment. The proposed K01 will not only demonstrate the value of the elephant to further understand human aging, but it will elucidate how early-life trauma influences an individual’s biological and social trajectory. Summary: Findings from this study will inform an R01 grant application to expand the study of early-life trauma and aging using the elephant. This K01 will develop my new expertise in psychobiology, aging, and randomized experiments. At the end of this award, I will be a leading independent scientist conducing innovative research in the field of aging.

项目概要/摘要 培训：过去八年我的研究主要集中在大象内分泌学、健康和 这项工作表明大象和人类之间有许多相似之处（例如，疾病、 生活史、社交性、情感复杂性），以及利用通过研究大象收集的信息 拟议的 K01 职业发展培训计划以此为基础。 经验，但确定了需要额外培训的三个领域：（1）发展心理生物学方面的专业知识和 行为，(2) 增强衰老科学和方法的技能，(3) 培养设计和实施的技能 因此，我们建议进行强化主题指导、重点课程作业和 通过拟议的研究进行情境学习将提供受保护的时间来接收所需的信息。 培训以增强我在这三个领域的专业知识，并将推动我成为一名独立研究人员 专注于健康老龄化的科学家：经历过不良童年经历的人。 (ACE) 增加了晚年患身体和心理疾病的风险，为 1.6 至 2.4。 成年后患肥胖、癌症、心脏病、中风和糖尿病的可能性以及预期寿命增加一倍 最多可缩短 20 年。了解 ACE 如何导致成年期疾病对于发育非常重要。 拟议的 K01 试图通过以下方式满足这一需求。 以下目标：展示使用大象作为人类衰老模型的价值，并阐明 早期生命创伤如何影响个体的生物和社会轨迹，与人类一样，小牛也具有高度的影响。 对母亲的依赖和依恋，在目睹母亲被杀后可能会患上创伤后应激障碍。 随机偷猎大象以获取象牙提供了一个自然实验来比较遭受高度创伤的大象 孤儿象与非孤儿象的动态负荷、生物年龄、认知和 这将是我们所知的第一项利用大象来了解疾病易感性的研究。 早期生活创伤的影响，同时也实施了一项随机实验，所提出的 K01 不会。 仅展示大象对于进一步了解人类衰老的价值，但它将阐明早期生命如何 摘要：这项研究的结果将为我们提供信息。 一项 R01 拨款申请，旨在利用大象扩大早期生命创伤和衰老的研究。 在这个奖项结束时，我将发展我在心理生物学、衰老和随机实验方面的新专业知识。 成为在衰老领域进行创新研究的领先独立科学家。