Mentoring and Research in Biobehavioral Aspects of Pediatric Pain

小儿疼痛生物行为方面的指导和研究

• 批准号: 10370988
• 负责人: LAURA E SIMONS
• 金额: $ 19.67万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370988
• 关键词: Adolescent; Affective; Award; Caring; Characteristics; Child; Childhood; Clinical; Clinical Trials; Cognitive; Collaborations; Communication; Coupled; Data; Data Analyses; Development; Disabled Children; Ensure; Ethical Issues; Evaluation; Family; Focus Groups; Funding; Future; Health; Health Services Accessibility; Healthcare; Intervention; Interview; Leadership; Legal; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Musculoskeletal Pain; Neurosciences; Outcome; Pain; Pain management; Parents; Participant; Patients; Pediatric Research; Personal Satisfaction; Persons; Physical therapy; Physicians; Process; Provider; Psychology; Recovery; Research; Research Methodology; Research Personnel; Resources; Scientist; Sentinel; Site; Teenagers; Time; Training; Translating; United States National Institutes of Health; Work; Youth; biobehavior; biopsychosocial; career development; chronic musculoskeletal pain; chronic pain; clinical care; cohort; digital health; evidence base; expectation; experience; human subject; improved; improved outcome; innovation; multidisciplinary; multimodality; neglect; neuroimaging; next generation; opioid epidemic; patient engagement; patient oriented; patient oriented research; recruit; response; skills; success; theories; virtual; years lived with disability

Project Summary The overall objective of this K24 application is to expand my current patient-oriented research (POR) and mentoring to integrate patient engagement from research to dissemination of care to improve the biobehavioral care of youth with chronic MSK pain. This award will provide the crucial protected time to enhance my quality and quantity of mentoring of junior investigators focused on POR including current K awardees, future T-32 fellows, and clinical fellows (physician and psychology). My currently supported POR encompasses translating targeted biopsychosocial assessments into mechanistically informed treatment approaches for optimal clinical care, coupled with pain neuroscience psychology that leverages experimental and neuroimaging methods to gain a mechanistic understanding of cognitive and affective processes that coalesce with function in children with chronic pain and their parents. All projects leverage the ubiquity of digital health to enhance patient access and reach. Our lab has world-leading expertise in theory- and mechanism-oriented research for patients and their families. The new direction of research to be supported through this award focuses on gaining new expertise in scientifically rigorous qualitative and codesign methods to partner with patients and their families across all stages of research. This application proposes two studies with significant mentoring opportunities within my long- term research objective to improve the health and well-being of youth with chronic pain. Study 1 characterizes the lived experience of youth with musculoskeletal (MSK) pain seeking, completing, and reflecting on pain care. Study 2 aims to codesign an optimization of our evidence-based graded exposure treatment for adolescents with chronic MSK pain and their parents, GET Living. The K24 builds on my previous research, leverages existing cohorts and data, adds new training, and solidifies collaborations with leaders in patient participatory research and qualitative data analysis to provide effective mentorship to the next generation of POR pediatric pain scientists. With support from the K24 award, I will enhance my mentoring capacity and I will work to enhance my career development with activities relevant to my mentees, my research, and my professional development. Specifically, I plan to deepen my understanding of qualitative data methods and analysis and patient participatory research methods. Moreover, I will dedicate time to ensure continued training in legal and ethical issues associated with research on human subjects and clinical trials and strengthen my professional leadership skills. The proposed studies provide the ideal context for enhancing mentorship opportunities via hands-on training and scientific development in the biobehavioral aspects of pediatric chronic pain applying patient-centered methods. With dedicated time and training from the K24, I will be better equipped to mentor the next generation of POR pediatric pain scientists and weave a patient-centered approach into all research from inception to execution.

项目摘要 该K24应用的总体目的是扩大我目前面向患者的研究（POR）和 指导将患者参与到从研究到分发护理以改善生物行为的参与度 护理慢性MSK疼痛的青年。该奖项将为提高我的质量提供关键的保护时间 以及重点关注POR的初级调查人员的指导数量，包括当前的K获奖者，未来的T-32 研究员和临床研究员（医师和心理学）。我目前支持的POR包含翻译 有针对性的生物心理社会评估对机械知情的治疗方法的最佳临床治疗方法 护理，再加上疼痛神经科学心理学，利用实验和神经影像学方法 对与儿童的功能结合的认知和情感过程获得机械理解 慢性疼痛和他们的父母。所有项目都利用数字健康的普遍性来增强患者的访问 并到达。我们的实验室在针对患者的理论和机制研究方面具有世界领先的专业知识， 他们的家人。通过该奖项支持的新研究方向重点是获得新的专业知识 在科学严格的定性和代码方面，可以与患者及其家人合作 研究阶段。该申请提出了两项​​研究，并在我的长期内具有重要的指导机会 术语研究目标，以改善慢性疼痛的青年的健康和福祉。研究1的特征 肌肉骨骼（MSK）疼痛寻求，完成和反思疼痛护理的年轻人的生活经验。 研究2旨在编码我们针对青少年的基于证据的分级暴露处理的优化 慢性MSK疼痛及其父母，生活。 K24以我以前的研究为基础 人群和数据，增加了新的培训，并巩固了与患者参与性研究领导者的合作 和定性数据分析，为下一代小儿疼痛提供有效的指导 科学家。在K24奖的支持下，我将增强我的指导能力，我将努力增强我的指导能力 与我的受训者，研究和我的专业发展有关的活动的职业发展。 具体而言，我计划加深对定性数据方法和分析以及患者参与性的理解 研究方法。此外，我将花时间确保在法律和道德问题上继续培训 与人类受试者和临床试验的研究相关，并增强了我的专业领导能力。 拟议的研究为通过动手培训增强指导机会的理想背景 以及小儿慢性疼痛的生物行为方面的科学发展，以患者为中心 方法。通过K24的专门时间和培训，我将有能力指导下一代 小儿小儿疼痛科学家，并以患者为中心的方法从开始到所有研究 执行。