Integrators of Metastatic Potential

转移潜能积分器

• 批准号: 10372682
• 负责人: Pradipta Ghosh
• 金额: $ 9.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372682
• 关键词: Automobile Driving; Back; Biochemical; Biological Assay; Biomedical Research; Breast Cancer Cell; Breast cancer metastasis; Cells; Cellular biology; Cessation of life; Complement; Data Analyses; Family; Grant; Learning; Manuscripts; Mechanics; Metastatic breast cancer; Methods; Molecular Biology; Morbidity - disease rate; Neoplasm Metastasis; Patients; Process; Publishing; Quantitative Microscopy; Research; Signal Transduction; Signaling Molecule; Solid Neoplasm; base; career; experimental study; malignant breast neoplasm; mouse model; predictive marker; skills; therapeutic target

Metastases cause major morbidities and nearly all of deaths in patients with breast cancer and other solid tumors. Our preliminary studies point to an intracellular signaling molecule, GIV, as a central determinant of metastatic potential of breast cancer cells. GIV integrates signals from multiple biochemical and mechanical inputs, placing this molecule as a central hub for key processes driving metastasis. In the parental RO1, we propose to investigate functions of GIV in breast cancer metastasis through a combination of cell-based assays and mouse models. We expect these studies to establish GIV as a potential predictive biomarker and therapeutic target for breast cancer. The research re-entry supplement will support the applicant and her return to a research career. The applicant will participate in all aspects of the proposed research, including planning experiments, analyzing data, and publishing manuscripts. She will learn new experimental methods focused on multi-scale, quantitative microscopy to complement her existing skills in cell and molecular biology. The supplement will enable the applicant to successfully transition back into a successful career in biomedical research.

转移引起乳腺癌和其他固体患者的主要病毒和几乎所有死亡 肿瘤。我们的初步研究指出，细胞内信号分子GIV作为中心决定因素 乳腺癌细胞的转移潜力。 GIV集成了来自多种生化和机械的信号 输入，将该分子作为驱动转移的关键过程的中心枢纽。在父母的RO1中，我们 建议通过基于细胞的组合研究GIV在乳腺癌转移中的功能 测定和鼠标模型。我们希望这些研究将GIV确立为潜在的预测生物标志物，并且 乳腺癌的治疗靶标。研究重新进入补充剂将支持申请人及其返回 从事研究职业。申请人将参与拟议研究的各个方面，包括计划 实验，分析数据和发布手稿。她将学习专注于的新实验方法 多尺度的定量显微镜，以补充其现有的细胞和分子生物学技能。这 补充剂将使申请人能够成功地过渡到生物医学领域的成功职业 研究。