Menstrual Phase and Sexual Dysfunction After Concussion in Women

女性脑震荡后的月经期和性功能障碍

• 批准号: 10369768
• 负责人: Martina Anto-Ocrah
• 金额: $ 3.63万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369768
• 关键词: Accident and Emergency department; Acute; Affect; Age; Arousal; Biological; Biological Markers; Brain Concussion; Brain Injuries; Caring; Clinical; Consequentialism; Development Plans; Disease; Drops; Emergency department visit; Emotional; Epidemiologist; Epidemiology; Female; Goals; Health; Hormonal; Human; Hypothalamic structure; Injury; Measures; Menstrual cycle; Mental Health; Mentors; Mild Concussions; Minority; Morbidity - disease rate; National Institute of Neurological Disorders and Stroke; Neurology; Outcome; Participant; Pathology; Patient Self-Report; Patients; Phase; Physiological; Pituitary Gland; Post-Concussion Syndrome; Premenopause; Progesterone; Progestins; Prospective cohort; Public Health; Quality of life; Questionnaires; Recovery; Reporting; Reproductive Health; Research; Research Project Grants; Research Proposals; Risk; Serum; Sex Behavior; Sex Differences; Sex Functioning; Sexual Arousal; Sexual Dysfunction; Sexuality; Source; Subgroup; Surveys; Symptoms; Testing; Time; Training; Withdrawal; Woman; Women' s Group; Women' s Health; World Health Organization; affective disturbance; base; birth control; bridge program; career; career development; clinical care; cohort; concussive symptom; design; digital; experience; follow-up; functional decline; high risk; high risk population; improved; injured; interest; limb injury; men; mild traumatic brain injury; novel; patient subsets; physical conditioning; proliferative phase Menstrual cycle; psychologic; recruit; reproductive; reproductive epidemiology; response; risk stratification; satisfaction; sex; sexual encounter; steroid hormone; tool; trauma centers

Emerging research suggests that changes in sexual functioning after concussion/mild traumatic brain injury (mTBI) are common in women of reproductive age (18-45years). Findings from my pilot research show that 61.3% of women who sustain a concussion report sexual dysfunctions (SD)-defined as disordered sexual interest, desire, arousal or satisfaction-compared to 40% of extremity injured controls of similar menstrual and birth control status. Although concussion symptoms typically resolve within weeks, this line of research demonstrates that for a subgroup of patients, symptoms can linger into months if not years, and can adversely affect an important, yet understudied, aspect of women’s health and function. Human sexuality, according to the World Health Organization (WHO), is an essential aspect of health, a central aspect of “being human.” Poor sexual functioning assumes pathology in the experience of sexual arousal, interest, desire and response, and it has been associated with adverse physical and mental health. It is a marker of quality of life (QOL). In order to decrease the public health burden of mTBI and improve the clinical care of women with concussion, research is needed to identify women at greatest risk for post- concussion SD. Understanding sex-difference in TBI outcomes and the unique challenges faced by women with TBI is a priority for the Neurology’s National Institute of Neurological Disorders and Stroke (NINDS). This K01 application proposes a research plan that incorporates hormonal biomarkers as a novel risk stratification tool to identify high risk groups of female concussion patients. Study participants will use the Ovia® digital reproductive health tracking application (app) and other validated questionnaires to document their sexual activities and relevant covariates. In Aim 1 we test the hypothesis that compared to women with extremity injuries, concussed women will a) have a lower mean score on the BIQS measure of sexual function and b) have fewer sexual encounters reported with Ovia app, evaluated at 1& 3-months post-injury. In Aim 2 we test if women with mTBI injured during the luteal menstrual phase will have a higher risk of SD than women with mTBI injured during the follicular menstrual phase (lower mean score on BIQS and fewer sexual encounters with app); and if the magnitude of the association will be significantly higher for women with mTBI than for women with extremity injuries. I will receive mentoring, career advising and training to develop an independent research program that bridges my epidemiologic skillset with my interests in neurology and reproductive epidemiology.

新兴研究表明，脑震荡/轻度创伤性脑损伤后性功能的变化 （MTBI）在生殖年龄（18-45岁）中很常见。 61.3％的维持脑震荡的妇女报告性功能障碍（SD）被定义为无序的性功能 兴趣，欲望，唤醒或饱腹感，占相似月经的四肢受伤控制的40％ 节育状态。 证明，对于患者亚组，症状可能会持续数月，即使不是不明确 影响妇女健康和功能的重要而又研究的方面。 根据世界卫生组织（WHO）的说法，人类性行为是健康的一个方面 “成为人类”的主要方面。性功能不佳 唤醒，兴趣，欲望和反应，并且与不利和心理健康有关。 是生活质量的标志（QOL）。 需要进行脑震荡的女性的临床护理，需要进行研究，以确定妇女的最大风险。 脑震荡SD。 TBI是神经病学国家神经系统疾病和中风研究所（NINDS）的优先事项。 该K01应用提出了一项研究计划，将荷尔蒙生物标志物纳入一种新型风险 分层工具确定女性一致性的高风险群体。 OVIA®数字生殖健康跟踪应用程序（APP）和其他经过验证的问卷 他们的性活动和相关的协变量。 在AIM 1中，我们检验了与肢体伤害妇女相比的假设，脑震荡的女性将A） 在性功能的BIQ量度上，平均得分较低，而性交的次数较少 用OVIA应用报告，在伤害后1个月和3个月进行评估。 在AIM 2中，我们测试了在黄体月经期间MTBI受伤的妇女是否会有更高的SD风险 比在卵泡月经期受伤的女性受伤的女性（BIQ的平均得分较低，更少 与应用程序的性相遇；如果有关联的幅度将大大适用于女性。 MTBI比肢体受伤。 我将获得指导，职业咨询和培训，以制定一个独立的研究计划 桥接我对神经病学和生殖流行病学的兴趣的流行病学技能。