North Carolina Translational and Clinical Science Institute (NC TraCS) TL1

北卡罗来纳州转化与临床科学研究所 (NC TraCS) TL1

基本信息

批准号：
10364744
负责人：
PRABIR ROY-CHAUDHURY
金额：
$ 41.7万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-30 至 2023-02-28
项目状态：
已结题

项目摘要

J. Training Core Abstract Collaborative interdisciplinary teams are critical to achieve and translate high impact science, yet multiple fields of expertise, each having its own language and culture, must be integrated and coordinated to achieve the goal of translation. To diminish barriers to translational efficiency, innovative training programs are needed to develop a cadre of researchers with the skills to `speak the language' across the translational continuum. UNC possesses the resources and commitment to develop innovative strategies to address this critical training need. This emerging translational research workforce will become key team members and leaders who bridge current divides across disciplines and setting, adapt methods and approaches from different disciplines and integrate them into research, and effectively communicate with a broad group of stakeholders. In our view, three core milestones are central to the translation of biomedical discoveries: (1) moving discoveries through the process of commercialization/entrepreneurship; (2) evaluating products in clinical trials; and (3) bringing discoveries or evidence-based practices into integrated health systems. We propose a new TL1 postdoctoral training program focused toward track-specific immersion in one of these three translational themes. We have chosen the tracks in this program because they are in alignment with the goals of TraCS and the NIH. We will leverage existing programs and expertise including those of TraCS, the Carolina Health Informatics Program (CHIP) and Computational Biology programs, the clinical trials infrastructure, our Partnership for Entrepreneurial Commercialization of UNC Chapel Hill Technology, and the UNC Health Care System. The experienced Training Core Leadership Team will be joined by: (1) faculty mentors who have the scientific and/or clinical content expertise to further translate this product or idea, (2) resource experts whose primary responsibilities are to operationalize translation, and (3) discipline-specific informatics experts who can direct the trainee to informatics methods and resources relevant to their project. Our overarching goal is: to train a cadre of postdoctoral fellows who wish to become translational scientists by immersing them in the translation of research products within one of three tracks in the translational pipeline— clinical trials, commercialization and entrepreneurship, or health systems. We will accomplish this goal by: (1) providing fellows with the didactic and experiential training to develop and apply skills in their targeted area to become leaders and effective members of translational research teams, and (2) increasing retention in translational science by facilitating transition of fellows to individual research training awards, employment or other appropriate mechanisms of research support. Effective translation is a “team sport”, and our goal is to create a training environment that includes the best science coupled with effective operationalization required for translation. This training will prepare TL1 fellows to serve as leaders across the translational pipeline who can both coalesce and manage future teams.

J. 培训核心摘要跨学科协作团队对于实现和转化高影响力的科学至关重要，但涉及多个领域各种专业知识都有自己的语言和文化，必须整合和协调才能实现目标为了减少翻译效率的障碍，需要创新的培训计划培养一支具有跨北卡罗来纳大学翻译连续体“讲语言”技能的研究人员队伍。拥有资源和承诺来制定创新战略来解决这一关键培训这些新兴的转化研究人员将成为关键的团队成员和领导者。当前跨学科和环境的分歧，来自不同学科和领域的适应性方法和方法我们认为，将它们纳入研究，并与广泛的利益相关者进行有效沟通。三个核心里程碑对于生物医学发现的转化至关重要：(1) 将发现转化为商业化/创业过程；（2）评估临床试验中的产品；以及（3）将发现或基于证据的实践纳入综合卫生系统。我们提出了一个新的 TL1 博士后培训计划，专注于特定领域的沉浸其中我们在这个节目中选择了三个翻译主题，因为它们与我们将利用 TraCS 和 NIH 的现有计划和专业知识。卡罗莱纳州健康信息学计划 (CHIP) 和计算生物学计划、临床试验基础设施、我们的北卡罗来纳大学教堂山技术创业商业化合作伙伴关系，以及北卡罗来纳大学医疗保健系统经验丰富的培训核心领导团队将由以下人员组成：(1) 教职员工拥有科学和/或临床内容专业知识以进一步转化该产品或想法的导师，(2) 主要职责是实施翻译的资源专家，以及 (3) 特定学科信息学专家可以指导学员了解与其项目相关的信息学方法和资源。我们的总体目标是：培养一批希望成为转化科学家的博士后骨干让他们沉浸在翻译管道中三个轨道之一的研究产品翻译中—— 临床试验、商业化和创业或卫生系统我们将通过以下方式实现这一目标：(1) 为研究员提供教学和体验培训，以发展和应用其目标领域的技能成为转化研究团队的领导者和有效成员，以及（2）提高保留率转化科学，通过促进研究员过渡到个人研究培训奖项、就业或其他适当的研究支持机制。有效的翻译是一项“团队运动”，我们的目标是创造一个包括最优秀人才的培训环境科学与翻译所需的有效操作相结合，该培训将为 TL1 研究员做好准备。担任整个转化管道的领导者，既可以合并又可以管理未来的团队。