Core B: Small Animal Radiation Core

核心B：小动物辐射核心

基本信息

批准号：
10360421
负责人：
Constantinos Koumenis
金额：
$ 18.39万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10360421
关键词：
Address Affect Animal Housing Animal Model Animals Area Back Blood Body Temperature Breeding Center for Translational Science Activities Clinical Clinical Oncology Collection Dose Ecosystem Elevator Ensure Experimental Neoplasms Exposure to Goals Grant Housing Human Resources Image Immune response Immune system Immunotherapy Implant Institution Investigation Knowledge Malignant Neoplasms Modality Modeling Monitor Movement Mus Normal tissue morphology Patients Photons Physics Procedures Process Proton Radiation Protons Quality Control Radiation Radiation Dose Unit Radiation Oncology Radiation therapy Radioimmunotherapy Regulation Reproducibility of Results Research Research Personnel Robotics Role Running Schedule Scheme Schools Services Standardization Supervision System Systems Analysis Temperature Tissue Harvesting Tissues Transplantation Tumor Tissue Variant Washington animal facility base cone-beam computed tomography cost efficient design dosimetry experience experimental study image-guided radiation immune checkpoint blockade innovation instrument irradiation microbiome operation pancreatic cancer model pathogen programs proton beam proton therapy radiation delivery radiation response response treatment delivery technique treatment planning tumor tumor-immune system interactions

项目摘要

PROJECT SUMMARY The overall goal of the Small Animal Radiation Core (SARC) is to provide “turn-key” animal housing and photon and proton radiation (including image-guided radiation) to tumors implanted into syngeneic mice as well as spontaneous, autocthonous tumors. Moreover, it will furnish accurate dosimetry and quality control necessary for successful completion of the studies proposed in Projects 2 and 3. A key feature of this Core is the centralization and standardization of services intended to minimize inter-animal variability in terms of immune system regulation and tumor response to radiation. We have devised a streamlined process for movement of animals from ordering (C57/Bl6) or procuring them from breeding (KPC pancreatic tumor model) to tumor radiation and back to housing until the animals are euthanized and tumors and tissues are harvested. At the center of this Core is a dedicated animal holding facility and a brand new renovated animal treatment room which will house and already available and established Small Animal Radiation Research Platform (SARRP) instrument from X-Strahl, Inc as well as dedicated proton Beam available in the Smilow Center for Translational Research (SCTR). The three main aims of this core are: Aim 1: To establish a dedicated housing suite with controlled environmental parameters. Aim 2: To deliver both Photon and Proton-based irradiation to mouse tumors in a conformal manner using the Small Animal Radiaiton Platform (SARRP) and available Proton Beam thereby avoiding radiation of normal tissues as much as possible. Aim 3: To develop precise dosimetry and quality-control analysis systems to ensure the prescribed dose was delivered to the target. The two co-Directors, Drs. Koumenis and Solberg, bring considerable expertise in small animal radiation as well as managing radiation facilities both at Penn and prior Institutions. Successful implementation of these services will provide the Project Leaders seamless and uniform treatment modalities and has the potential to serve as a model facility for other similar research efforts world-wide.

项目概要小动物辐射核心 (SARC) 的总体目标是为动物提供“交钥匙”服务对植入肿瘤的外壳以及光子和质子辐射（包括图像引导辐射）此外，它还将提供同基因小鼠以及自发的、自体肿瘤。成功完成研究所必需的准确剂量测定和质量控制项目 2 和 3 中提出。该核心的一个关键特征是集中化和服务标准化旨在最大限度地减少动物间免疫方面的差异系统调节和肿瘤对辐射的反应我们设计了一个简化的流程。动物从订购（C57/Bl6）或从繁殖中采购（KPC 胰肿瘤模型）到肿瘤辐射并返回饲养室，直到动物被安乐死并该核心的中心是一个专门的动物饲养场。设施和一个全新装修的动物治疗室，将容纳并已经可用并已建立的小动物辐射研究平台（SARRP）仪器 X-Strahl, Inc 以及 Smilow 转化中心提供的专用质子束研究 (SCTR)。该核心的三个主要目标是：目标 1：建立专门的研究中心。目标 2：提供光子和环境参数。使用小动物以保形方式对小鼠肿瘤进行质子照射辐射平台 (SARRP) 和可用的质子束从而避免正常辐射目标 3：开发精确的剂量测定和质量控制分析。系统，以确保将规定的剂量输送到目标。两位联合主任博士。 Koumenis 和 Solberg 带来了小动物辐射方面的丰富专业知识以及管理宾夕法尼亚大学和先前机构的辐射设施。这些服务将为项目负责人提供无缝、统一的治疗方式和有潜力成为世界范围内其他类似研究工作的典范设施。