Marijuana Use in Older Adults: Health, Function and Fall-Related Injury

老年人吸食大麻：健康、功能和跌倒相关伤害

• 批准号: 10360509
• 负责人: Salomeh Keyhani
• 金额: $ 57.81万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360509
• 关键词: Address; Adult; Adverse effects; Adverse event; Area; Benefits and Risks; Benzodiazepines; Caregivers; Cessation of life; Characteristics; Cognition; Cognitive deficits; Confusion; Data; Databases; Disorientation; Dizziness; Dose; Drowsiness; Elderly; Equilibrium; Event; Fatigue; Goals; Hallucinations; Health; Health Benefit; Health Status; Health behavior; Hospitalization; Injury; Interview; Legal; Link; Literature; Marijuana; Medical Records; Medicare; Memory impairment; Methods; Mood Disorders; Multiple Sclerosis; Nausea; Opioid; Outcome; Pain; Pain management; Paranoia; Patients; Perception; Pharmaceutical Preparations; Pharmacologic Substance; Plants; Polypharmacy; Population; Prevalence; Prospective cohort; Psyche structure; Psychoses; Psychotropic Drugs; Recording of previous events; Reporting; Research; Respiratory Tract Infections; Risk; Serious Adverse Event; Sleep; Sleeplessness; Smoking; Stress; Subgroup; Surveys; Telephone; Telephone Interviews; Tetrahydrocannabinol; Text; Veterans Health Administration; Vomiting; Washington; adverse event risk; adverse outcome; base; chronic pain; cohort; design; evidence base; fall injury; fall risk; follow-up; high risk; insight; marijuana use; marijuana user; mental state; older patient; respiratory; response; secondary outcome; side effect; systematic review

The prevalence of marijuana use among older adults is rising dramatically. Marijuana is being promoted as a harmless “herbal” treatment that can be used to treat insomnia, stress, caregiver fatigue, and pain, conditions that are common among the elderly. However, there is a complete lack of data on the effects of marijuana and its active component, tetrahydrocannabinol (THC), among older adults. In trials examining the effect of THC-based pharmaceuticals among younger populations and in specific conditions, serious adverse events reported included dizziness, nausea, somnolence, vomiting, disorientation, confusion, loss of balance, and hallucination. These adverse events of THC-based pharmaceuticals provide a framework to understand the potential harms of plant-based marijuana use in older adults. We hypothesize that marijuana use in older adults is associated with fall-related injury, any injury, and hospitalization for altered mental status and mood disorders. In addition, as smoking is the predominant form of use, respiratory complications are also likely. To address the extensive gap in the literature on the potential harms of marijuana in older adults, we propose to construct a cohort of patients 65 years and older in the Veterans Health Administration (VA) using merged national VA and Medicare data. Specifically, we propose to use validated text processing methods to review medical record notes and identify mentions of marijuana use to preliminarily categorize patients into marijuana users and non-users. We will then perform an in-depth 25-minute telephone health interview with each patient to ascertain exposure history and baseline characteristics. After adjusting for the baseline differences between users and non-users using the comprehensive interview data collected and the national VA data available, we will compare the rates of events among 2250 current marijuana users and 2250 non- users during the follow-up period. Our proposal will accomplish four goals: (1): To use a prospective cohort design to examine the association between marijuana use and the primary adverse outcome of all-cause hospitalization and the secondary composite outcome of all-cause hospitalization and death. (2) To use a prospective cohort design to examine the association between marijuana and the secondary outcomes of fall-related injury, any injury, altered mental status, mood disorders, and respiratory infections. (3) To examine whether specific subgroups of older patients are more likely to experience adverse outcomes. (4) To determine whether there is a level of safe use of marijuana in older adults. Though very little is known about the physical harms of marijuana in older adults, it is likely that use of marijuana is associated with adverse effects. Given increasing use among older adults, a better understanding of the risks of marijuana use in this population is urgently needed to disseminate accurate information to the public.

老年人吸食大麻的流行率正在急剧上升。 作为一种无害的“草药”疗法，可用于治疗失眠、压力、护理人员疲劳和疼痛， 然而，完全缺乏有关其影响的数据。 在检查老年人中大麻及其活性成分四氢大麻酚（THC）。 基于 THC 的药物对年轻人和特定条件下的影响，严重不良反应 报告的事件包括头晕、恶心、嗜睡、呕吐、迷失方向、精神错乱、失去平衡、 THC 药物的这些不良事件提供了一个理解框架。 老年人使用植物性大麻的潜在危害。 成人与跌倒相关的伤害、任何伤害以及因精神状态和情绪而住院治疗有关 此外，由于吸烟是主要的使用方式，因此也可能出现呼吸道并发症。 为了解决有关大麻对老年人潜在危害的文献中存在的巨大空白，我们 建议在退伍军人健康管理局 (VA) 中构建一组 65 岁及以上的患者队列，使用 具体来说，我们建议使用经过验证的文本处理方法来合并国家 VA 和 Medicare 数据。 审查病历记录并识别大麻使用的提及，以将患者初步分类为 然后，我们将对大麻使用者和非使用者进行深入的 25 分钟电话健康访谈。 调整基线后，确定每位患者的暴露史和基线特征。 使用收集到的综合访谈数据和国家统计数据来了解用户和非用户之间的差异 VA 数据可用，我们将比较 2250 名当前大麻使用者和 2250 名非大麻使用者的事件发生率 后续期间的用户。 我们的建议将实现四个目标：（1）：使用前瞻性队列设计来检查 大麻使用与全因住院主要不良结局之间的关联 (2) 采用前瞻性队列设计 检查大麻与跌倒相关伤害、任何伤害、 (3) 检查特定子组是否 (4)判断是否存在等级 老年人安全使用大麻。 尽管人们对大麻对老年人的身体危害知之甚少，但使用大麻很可能 鉴于老年人使用大麻的情况越来越多，人们对大麻的认识也越来越深入。 迫切需要了解该人群吸食大麻的风险，以便向公众传播准确的信息 民众。