Sleep-dependent negative overgeneralization in peri-pubertal anxiety

围青春期焦虑中睡眠依赖性消极过度概括

基本信息

批准号：
10357320
负责人：
DANA L MCMAKIN
金额：
$ 4.41万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10357320
关键词：
Address Adolescent Age Anger Anxiety Anxiety Disorders Award Behavior Behavioral Canis familiaris Child Childhood Clinic Clinical Data Clinical Services Clinical Trials Cognitive Therapy Complex Data Data Collection Data Reporting Development Diffuse Distal Etiology Evidence based treatment Exhibits Exposure to Fire - disasters Functional Magnetic Resonance Imaging Future Generations Hand Health Hippocampus (Brain)Intervention Life Experience Measures Memory Mental Depression Methods Modeling National Institute of Mental Health Neurosciences Outcome Participant Patient Self-Report Phenotype Positioning Attribute Process Protocols documentation Puberty Research Research Support Research Training Severities Sleep Stimulus Strategic Planning Suicide Testing Theoretical model Treatment outcome Youth anxiety reduction base behavior measurement career development childhood anxiety conditioned fear high risk indexing insight learning extinction memory recall multimodality neuroimaging novel outcome prediction parent grant precision medicine prospective recruit relating to nervous system response substance use theories therapy outcome treatment of anxiety disorders

项目摘要

PROJECT SUMMARY Cognitive-Behavioral Therapy (CBT) is the most well-established treatment for anxiety disorders, yet up to one- half of peri-pubertal youth show insufficient response, leaving these youth at high risk for continued anxiety, depression, substance use, and suicide. This proposed Diversity Supplement aims to supplement parent grant data on negative overgeneralization with data collected from clinical services CBT, offered to participating youth, to (a) examine negative overgeneralization as a predictor of CBT outcomes and (b) support the research training and career development of the candidate, Carlos Yeguez. Negative overgeneralization is a phenotype of anxiety that refers to the tendency to generalize aversive responses from one context (house fire) to other contexts (camp-fire) that share features. In our conceptual model, participants who exhibit high negative overgeneralization present a broad, diffuse target that hinders CBT outcomes. Specifically, in these participants information learned in the context of exposure to one anxiety-provoking stimulus will not readily transfer to distally-related stimuli, requiring more intensive and longer exposure to achieve optimal outcomes. Peri-puberty provides the optimal window for preliminarily testing aspects of our conceptual model because gradients of negative overgeneralization become more pronounced during this developmental window. In accordance with the NIMH strategic plan, we examine negative overgeneralization as a multi-modality derived phenotype associated with CBT outcome using neuroimaging, behavior task, and self-report data from the parent grant. Further, we characterize the phenotype of negative overgeneralization using a declarative memory paradigm. Declarative memory paradigms are sensitive to neurodevelopmental differences in youth with anxiety disorders and enhance ecological validity because they approximate complex experiences of life and use of exposures in CBT. Further, our paradigm allows us to measure neurocomputational processes underlying negative overgeneralization based on theory and data from our team documenting its relationship with anxiety severity in peri-pubertal youth. In this proposed supplement, we will recruit a subset of N=50 peri- pubertal youths ages 10-13 years with anxiety disorders drawn from the parent grant. After completing the parent grant protocol, participants will then complete CBT for anxiety disorders offered through our team’s clinic and supplemental data collection on anxiety outcomes and self-report measures of negative overgeneralization. In Aim 1 we examine a behavioral measure of negative overgeneralization as a predictor of CBT outcome. In Aim 2 we examine a neural measure of negative overgeneralization as a predictor of CBT outcome. In Aim 3 we examine whether self-reported negative overgeneralization is associated with behavioral and neural measures of negative overgeneralization at baseline, and whether our behavioral, neural, and self- report indices of negative overgeneralization at baseline predict self-reported negative overgeneralization across treatment by examining changes in weekly self-reported negative overgeneralization.

项目摘要认知行为疗法（CBT）是焦虑症的最公认的治疗方法，但最多可青年周日青年的一半表现不足，使这些年轻人有持续动画的高风险，抑郁，吸毒和自杀。拟议的多样性补充旨在补充父母的赠款从临床服务CBT收集的数据中，有关负面概括过度概括的数据，旨在参与年轻人，（a）检查负面概括是CBT结果的预测指标，（b）支持候选人Carlos Yeguez的研究培训和职业发展。负过度概括是焦虑表型是指从一种情况下概括厌恶反应的趋势（房屋火）在其他共享特征的情况下（营地）。在我们的概念模型中，暴露高的参与者负过度概括提出了阻碍CBT结果的广泛，弥漫性的目标。具体而言，在这些中参与者在暴露于一种焦虑的刺激的背景下学习的信息将不容易转移到与单独的相关刺激中，需要更密集，更长的暴露才能获得最佳结果。 Peri-Puberty为我们概念模型的初步测试方面提供了最佳窗口，因为在此发展窗口中，负过度泛化的梯度变得更加明显。在因此，通过NIMH战略计划，我们将负面概括性过度归类为多模式得出使用神经影像学，行为任务和自我报告数据与CBT结局相关的表型父母赠款。此外，我们使用声明性表征了负过度笼过的表型内存范式。声明性记忆范例对青年的神经发育差异敏感焦虑症并提高生态有效性，因为它们近似生命的复杂经历并在CBT中使用暴露。此外，我们的范式使我们能够测量神经计算过程基于基于理论和我们团队文档的数据的负面概括性过度过度化的关系青年周日青年的焦虑严重程度。在此拟议的补充中，我们将招募n = 50的子集从父母赠款中提取的焦虑症的青少年年轻人10-13岁。完成后父母赠款协议，参与者将完成CBT，以解决我们团队提供的动画障碍临床和补充数据收集焦虑症状和自我报告量度负面的措施过度概括。在AIM 1中，我们研究了负面过度过度化的行为测量作为预测指标 CBT结果。在AIM 2中，我们检查了对CBT的预测指标的神经度量的神经度量结果。在AIM 3中，我们检查了自我报告的负面过度笼过是否与行为相关基线时负面概括过度过度的神经测量，以及我们的行为，神经和自我基线时负面概括过度过度概括的报告指数预测自我报告的负面概括通过检查每周自我报告的负面概括过度的变化，通过检查治疗。