RADx-UP CDCC SAY YES COVID Test Study

RADx-UP CDCC 同意 COVID 测试研究

• 批准号: 10366485
• 负责人: Michael Cohen-Wolkowiez
• 金额: $ 765.38万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-27 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10366485
• 关键词: 2019-nCoV; Address; Admission activity; Affect; Attitude; Behavior; Behavioral; Bioinformatics; Biometry; COVID test; COVID-19 pandemic; Centers for Disease Control and Prevention (U.S.); Cessation of life; Clinical Research; Clinical Trials; Communities; Consent; Contact Tracing; County; Data; Data Collection; Disease; Epidemiology; Evaluation; Future; Goals; Health; Health Knowledge, Attitudes, Practice; Health behavior; High Prevalence; Home; Hospitalization; Hospitals; Human; Individual; Infection; Infrastructure; Intervention; Knowledge; Lead; Leadership; Measures; Morbidity - disease rate; North Carolina; Outcome; Participant; Population; Population Programs; Prevention; Public Health; Quarantine; RADx; Research; Research Institute; SARS-CoV-2 infection; SARS-CoV-2 transmission; Science; Site; Social Interaction; Target Populations; Testing; Time; Underserved Population; United States National Institutes of Health; Universities; Vaccines; Viral; Virus; Vision; cohort; community engagement; coronavirus disease; cost; experience; health care service utilization; health equity; home test; indexing; marginalized population; novel; novel strategies; operation; pandemic disease; primary outcome; programs; public health intervention; rapid test; research study; screening; secondary outcome; skills; smartphone Application; transmission process; uptake; wastewater surveillance

Over 4 million people have been infected with the SARS-CoV-2 virus and more than 460,000 have died. Novel mitigation strategies and community level public health interventions are critical to stop the spread of this virus. The goal of frequent home testing is to identify SARS-CoV-2 index cases early, trigger isolation and quarantining precautions, and ultimately decrease community transmission. We will evaluate a public health intervention combining frequent at-home testing with broad community engagement strategies, to reduce SARS-CoV-2 virus community transmission and conduct a study in a cohort of the population to understand the human behavior factors affecting viral testing. This approach will allow us to answer questions regarding community transmission for the SARS-CoV-2 pandemic as well as additional questions relevant for implementation of public health interventions in future pandemics. We will partner with the CDC to evaluate community dissemination of 2 million rapid tests in a public health intervention of rapid, twice weekly at home testing in up to 3 communities 1) with high prevalence of disease 2) that have reliable publicly available outcome data and 3) that overlap with current RADx-UP sites to leverage the robust infrastructure of the CDCC and support community engagement through the testing projects. To evaluate whether frequent rapid at-home testing strategy decreases community transmission of and morbidity from SARS-CoV-2 over a 5-week period, our primary outcomes include measures of community transmission (hospital capacity/health care utilization, composite measure of community transmission, wastewater surveillance), and morbidity (hospitalizations, covid-like illness). Our secondary outcomes include (community mobility, PCR turn-around time, ICU admissions, contact tracing episodes, and percent test positivity). In addition, we will conduct a substudy to assess behavioral determinants of testing (social interaction, health behaviors, healthcare utilization, prevention knowledge and vaccine attitudes) using a smart phone application with consenting participants in the public health intervention.

超过400万人感染了SARS-COV-2病毒，超过460,000人死亡。小说 缓解策略和社区层面的公共卫生干预措施对于阻止该病毒的传播至关重要。 频繁进行家庭测试的目的是尽早确定SARS-COV-2指数案例，触发隔离和 隔离预防措施，并最终减少社区传播。我们将评估公共卫生 干预将频繁的家庭测试与广泛的社区参与策略相结合，以减少 SARS-COV-2病毒社区传播并在一群人群中进行研究以了解 影响病毒测试的人类行为因素。这种方法将使我们回答有关 SARS-COV-2大流行的社区传播以及与 在未来大流行中实施公共卫生干预措施。我们将与CDC合作评估 社区传播200万快速测试，在快速的公共卫生干预措施中，每周两次 在多达3个社区中进行测试1）疾病患病率很高2）公开可靠的 结果数据和3）与当前RADX站点重叠以利用CDCC的稳健基础架构 并通过测试项目支持社区参与。评估是否频繁地在家中 测试策略可在5周的时间内降低SARS-COV-2的社区传播和发病率， 我们的主要结果包括社区传播的措施（医院能力/医疗保健利用， 社区传播，废水监测的综合度量）和发病率（住院， 类似疾病）。我们的次要结果包括（社区移动性，PCR转身时间，ICU 入学，接触示意发作和测试阳性百分比）。此外，我们将进行 评估测试的行为决定因素（社交互动，健康行为，医疗保健利用， 预防知识和疫苗态度）使用同意参与者使用智能手机应用程序 公共卫生干预。