Bringing to market an innovative, new mass spectrometer for rapid, robust, and detailed data on all components in complex mixtures

将创新型新型质谱仪推向市场，可快速、可靠且详细地获取复杂混合物中所有成分的数据

• 批准号: 10054996
• 金额: $ 110.74万
• 依托单位: VERDEL INSTRUMENTS LTD
• 依托单位国家: 英国
• 项目类别: Investment Accelerator
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10054996
• 关键词: Bringing; market; innovative; new; mass

Verdel Instruments Ltd, a University of Warwick spin-out, is developing an innovative and patented technology which will allow scientists to obtain detailed structural information for thousands of molecular compounds simultaneously. This uses a new technique called Total Correlation Mass Spectrometry (TOC-MS) that allows a user to fragment a wide range of molecules simultaneously and, at the same time, track which fragments come from which precursor molecules. Because TOC-MS performs these fragmentation studies in parallel on all compounds at once, rather than serially one compound at a time, it greatly speeds up the experiment.Verdel is developing a product akin to a routine benchtop instrument which will be fast enough to provide these comprehensive fragmentation datasets in a few seconds.TOC-MS can be applied across diverse areas, with current focus on lipid analysis to enable more detailed research into Parkinson's, Alzheimer's as well as cancer and metabolic diseases. Lipids are a wide and important class of chemical in the body ranging from hormones to lipoproteins.TOC-MS will also play an important role in the wider field of Proteomics, for example, the ability to measure all proteins in blood and to diagnose a wide range of diseases in one go. Further, by identifying the expressed (or under expressed) proteins of say cancer mutations, this technique could be a key enabling tool for precision medicine.More widely, this technology represents a step change in performance for almost all Mass Spec applications where there are complex mixtures and the additional information which will be produced with each analysis can provide a rich fingerprint of origin in the food and pharmaceutical industries as well as illegal drugs.This project will take the laboratory demonstrator design into a production-ready instrument for sale to customers over 12-18 months.

Verdel Instruments Ltd 是华威大学的子公司，正在开发一项创新的专利技术，该技术将使科学家能够同时获得数千种分子化合物的详细结构信息。它使用了一种称为全相关质谱 (TOC-MS) 的新技术，允许用户同时对多种分子进行碎片化，同时跟踪哪些碎片来自哪些前体分子。由于 TOC-MS 可以同时对所有化合物进行这些碎片研究，而不是一次连续研究一种化合物，因此大大加快了实验速度。Verdel 正在开发一种类似于常规台式仪器的产品，其速度足够快，可以提供TOC-MS 可应用于不同领域，目前的重点是脂质分析，以便对帕金森病、阿尔茨海默病以及癌症和代谢疾病进行更详细的研究。脂质是体内一类广泛而重要的化学物质，从激素到脂蛋白，TOC-MS 还将在更广泛的蛋白质组学领域发挥重要作用，例如，能够测量血液中的所有蛋白质并诊断广泛的蛋白质。一口气解决一系列疾病。此外，通过识别癌症突变的表达（或表达不足）蛋白质，该技术可能成为精准医学的关键工具。更广泛地说，该技术代表了几乎所有复杂的质谱应用的性能的阶跃变化。混合物和每次分析产生的附加信息可以提供食品和制药行业以及非法药物的丰富来源指纹。该项目将把实验室演示器设计转化为可立即生产的仪器，以便在超过12-18 个月。