Seizure control by electric field control

通过电场控制进行咬合控制

基本信息

批准号：
10365510
负责人：
DOMINIQUE M DURAND
金额：
$ 38.41万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10365510
关键词：
Acute Antiepileptic Agents Brain Characteristics Chronic Closure by clamp Computer Models Computer Simulation Coupling Data Electrodes Electrophysiology (science)Epilepsy Extracellular Space Focal Seizure Furosemide Generations Goals Hippocampus (Brain)Human Image In Vitro Interneurons Iron Kainic Acid Laboratories Mediating Membrane Methodology Methods Modeling Nerve Block Neurons Osmolar Concentration Partial Epilepsies Patients Pharmaceutical Preparations Play Preparation Recurrence Research Resistance Rodent Role Seizures System Techniques Technology Temporal Lobe Epilepsy Testing Tissues Travel Treatment Efficacy alternative treatment base design efficacy testing electric field experimental study extracellular in vivo neurotechnology new technology novel novel strategies novel therapeutics optogenetics prevent recruit relating to nervous system voltage voltage clamp

项目摘要

Abstract A seizure is an abnormal neural activity in the brain and the main characteristic of epilepsy. About one-third of the patients have seizures resistant to anti-epileptic medication and therefore, an alternative treatment is necessary. Recent studies show that neurons can be recruited and seizures can propagate by a mechanism known as electric field coupling. Our laboratory has shown that canceling the electric field in the extracellular space can prevent neural propagation and recruitment. We now propose to develop a novel neurotechnology that not only can control the propagation of seizures but prevent the seizure from being generated by controlling the extracellular electric field. With a combined methodology of in-vitro electrophysiology with state-of-the-art neural imaging, computer modeling and in-vivo preparations in rodents, we will implement the seizure control system and study its mechanism with four specific aims: 1) Prevent neuronal synchronization in hyperexcitable neural tissue, 2) Develop a novel technology of extracellular voltage clamp to control seizures in-vivo, 3) Determine the mechanisms of seizure control by an extracellular voltage clamp system, 4) Determine the role of the extracellular space in the clamping efficiency. Current electrical responsive control therapy detects a seizure and then applies stimulation. The proposed neurotechnology will prevent the synchronization between neurons to stop the generation of seizures before they arise at very low current amplitude thereby providing a novel therapeutic paradigm for treating epilepsy.

抽象的癫痫发作是大脑中异常的神经活性，也是癫痫的主要特征。大约三分之一患者的癫痫发作对抗癫痫药有抗性，因此，另一种治疗方法是必要的。最近的研究表明，可以招募神经元，并且癫痫发作可以通过一种机制传播称为电场耦合。我们的实验室表明，取消细胞外电场空间可以防止神经传播和招募。我们现在建议开发一种新颖的神经技术不仅可以控制癫痫发作的传播，而且可以防止癫痫发作通过控制产生细胞外电场。与维特罗电生理学的结合方法和最先进的方法论神经成像，计算机建模和啮齿动物中的体内制剂，我们将实施癫痫发作控制系统并以四个特定目的研究其机制：1）防止过度兴奋的神经元同步神经组织，2）开发了一种新型的细胞外电压夹具，以控制癫痫发作，3）通过细胞外电压夹系统确定癫痫发作控制的机制，4）确定夹紧效率的细胞外空间。当前的电反应性控制疗法检测到癫痫发作然后应用刺激。提出的神经技术将防止神经元之间的同步要在非常低的电流幅度出现之前停止发作的产生，从而提供了小说治疗癫痫的治疗范例。