Advancing Research on Mechanisms of Resilience (ARMOR): Prospective Longitudinal

推进弹性机制（ARMOR）的研究：前瞻性纵向

• 批准号: 10350682
• 负责人: MELISSA A. POLUSNY
• 金额: $ 60.2万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10350682
• 关键词: Adverse event; Alcohol consumption; Anxiety; Area; Attention; Behavior; Behavioral; Cognition; Cognitive; Collaborations; Data Collection; Data Set; Drug usage; Electroencephalography; Emotions; Enrollment; Environment; Evaluation; Exposure to; Goals; Growth; Healthcare Systems; Image; Individual Differences; Informal Social Control; Integrative Medicine; Laboratories; Life; Longevity; Longitudinal Studies; Longitudinal cohort study; Magnetic Resonance Imaging; Measurement; Measures; Mental Depression; Mental Health; Methods; Military Personnel; Mind-Body Intervention; Minnesota; Modeling; Monitor; Neurobiology; Participant; Pathway interactions; Patient Self-Report; Pattern; Personality Traits; Persons; Phase; Pilot Projects; Populations at Risk; Prevention; Probability; Procedures; Process; Psyche structure; Psychopathology; Psychophysiology; Regulation; Research; Research Personnel; Risk; Risk Factors; Scanning; Services; Social Functioning; Soldier; Spouses; Statistical Algorithm; Statistical Models; Stress; Surveys; Symptoms; Task Performances; Time; Training; Universities; Work; acceptability and feasibility; base; cognitive neuroscience; cohort; combat training; conduct problem; contextual factors; cost; developmental psychology; farmer; field study; first responder; flexibility; high risk; infancy; military service; neurobehavioral; novel; prediction algorithm; predictive modeling; preventive intervention; prospective; protective factors; recruit; resilience; response; service member; social; stressor

Background: Resilience is defined as the capacity to adapt successfully through multiple processes in response to adverse events. While explanatory models are still in their infancy, theoretical and empirical evidence suggest that self-regulatory processes may underlie resilient functioning. This proposal will develop (Phase 1, Year 1) and then implement (Phase 2, Years 2-5) a study of 1,200 National Guard recruits in the first two years of their enlistment in order to identify patterns and processes of adaptive (resilient) functioning in the face of Basic Combat Training (BCT) and other adverse events. Aims: The aims for Phase 1 are focused on planning and preparing for a longitudinal study of resilience in National Guard recruits and include: 1) Use prior datasets to develop statistical algorithms for selecting ilot baseline data collection procedures to determine feasibility of enrollment and response rate targets for longitudinal study, 3) Develop and refine contextualized measures of National Guard training stressor exposure, and 4) Evaluate the feasibility and acceptability of neurobehavioral markers of resilience processes. During Phase 2, a comprehensive model of resilience will be investigated using a four-year, mixed-method, longitudinal study to participants with high and low probabilities of resilience, 2) P 1) Characterize latent trajectories of adjustment among new military recruits beginning prior to BCT over two years, 2) Identify promotive and protective predictors of resilient functioning in National Guard soldiers, and 3) Investigate neurobehavioral pathways of self-regulation predictive of resilience trajectories in new military recruits. Procedures and Analyses: In Phase 1, prediction algorithms will be established using analysis of datasets gathered in prior National Guard studies. The measurement of BCT stressors, and feasibility of Phase 2 recruitment plans, will involve online surveys of 100 National Guard recruits before, during and immediately after BCT. The feasibility and acceptability of neurobiological measures through imaging and laboratory tasks piloting procedures will be assessed with 10 recruits undergoing procedures before and after BCT. In Phase 2, on-line self-reports of symptoms (depression, anxiety, alcohol or drug use), adaptive social functioning, and promotive, protective, and risk factors will be collected before and at 4 time points after BCT with 1200 National Guard recruits. Growth mixture modeling will establish resilient and non-resilient trajectories of adaptive functioning. Aim 2 will use predictive modeling of trajectories using predictors collected during the baseline and subsequent time points. In Aim 3, 120 recruits will complete laboratory tasks (Farmer's task, go/no-go task, dot probe task, performance monitoring task) before and after BCT while undergoing MRI or EEG scans. Analyses will determine if these tasks can discriminate between recruits in the resilient vs. non- resilient trajectories of functioning established in Aim 1.

背景：弹性定义为通过多个过程成功适应的能力 对不利事件的响应。虽然解释性模型仍处于起步阶段，但理论和经验 有证据表明，自我调节过程可能是弹性功能的基础。该建议将发展 （第1阶段，1年）然后在第一个中对1200名国民警卫队新兵进行了实施（第2阶段，第2-5年） 他们入伍的两年是为了识别自适应（弹性）功能的模式和过程 面对基本战斗训练（BCT）和其他不利事件。 目的：第一阶段的目的是计划和准备纵向研究的弹性研究 国民警卫队的新兵包括： 1）使用先验数据集开发选择统计算法 ILOT基线数据收集程序 确定纵向研究的入学人数和应答率目标的可行性，3）发展和完善 国民警卫队训练压力源暴露的情境化措施，以及4）评估可行性和 弹性过程的神经行为标记的可接受性。在第2阶段，一个全面的模型 将使用四年的混合方法，纵向研究对弹性进行研究 弹性概率高和低概率的参与者，2）P 1）表征潜在 两年内BCT之前从BCT之前开始的新军事新兵的调整轨迹，2）确定 国民警卫队士兵中有弹性功能的促进和保护性预测指标，3）调查 自我调节的神经行为途径可以预测新军事新兵的弹性轨迹。 过程和分析：在第1阶段，将使用数据集的分析来建立预测算法 聚集在先前的国民警卫队研究中。 BCT应激源的测量以及2阶段的可行性 招聘计划将涉及在线调查100名国民警卫队新兵 BCT之后。通过成像和实验室任务的神经生物学措施的可行性和可接受性 将在BCT之前和之后的10名新兵评估试点程序。 在第2阶段，症状的在线自我报告（抑郁，焦虑，酒精或吸毒），适应性社交 BCT之前和4个时间点的功能，促进，保护和风险因素将收集 有1200名国民警卫队新兵。生长混合物建模将建立弹性和非弹性轨迹 自适应功能。 AIM 2将使用在此期间收集的预测因素对轨迹进行预测建模 基线和随后的时间点。在AIM 3中，120名新兵将完成实验室任务（农民的任务， 在进行MRI或 脑电图扫描。分析将确定这些任务是否可以在弹性和非 - 非 - AIM 1中建立的功能轨迹的弹性轨迹。