Predictors of Momentary Smoking Lapse Among African American Menthol Cigarette Smokers

非洲裔美国薄荷醇卷烟吸烟者短暂戒烟的预测因素

• 批准号: 10351234
• 负责人: Dina Marie Jones
• 金额: $ 16.05万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10351234
• 关键词: Abstinence; Affect; African American; African American population; Behavior Therapy; Behavioral trial; Biochemical; Black race; Carbon Monoxide; Cessation of life; Cigarette; Cigarette Smoker; Competence; Consumption; Data; Dependence; Development Plans; Ecological momentary assessment; Electronic cigarette; Ethnic Origin; Exhalation; Goals; Health; Health Disparities Research; Intervention; Interview; K-Series Research Career Programs; Literature; Malignant Neoplasms; Mediating; Menthol; Mentorship; Moods; Morbidity - disease rate; Nicotine; Nicotine Dependence; Observational Study; Participant; Predictive Factor; Race; Randomized; Relapse; Research; Research Personnel; Role; Science; Scientist; Smoke; Smoker; Smoking; Smoking Prevention; Smoking Status; Surveys; Technology; Testing; Time; Tobacco; Training; aged; base; career; career development; cigarette smoke; cigarette smoking; contextual factors; efficacy testing; electronic cigarette use; experience; follow-up; mHealth; mobile application; negative affect; nicotine craving; novel; perceived discrimination; perceived stress; positive mood; prevent; primary outcome; recruit; secondary outcome; smoking cessation; smoking relapse; social disadvantage; statistics; success; summer institute; tobacco regulatory science

PROJECT SUMMARY Black cigarette smokers, 85% of whom smoke menthol cigarettes, suffer excess tobacco-caused morbidity and death, including cancer. Menthol (v. non-menthol) cigarette smokers, especially Black smokers, have a greater dependence on nicotine and are less likely to quit smoking, despite having more quit attempts. This may be partly due to greater abstinence-induced declines in positive mood/affect and nicotine cravings. However, there are limited data on the underlying mechanisms that explain smoking lapses among Black menthol smokers. Prior studies have used ecological momentary assessment (EMA) to examine how negative affect (i.e., poor mood), nicotine craving (i.e., urge to smoke), and contextual factors predict cigarette smoking lapse in real- time. Understanding these underlying mechanisms will help us develop effective cessation interventions for Black menthol smokers. To fill these critical research gaps, this study will use EMA to 1) examine the within- subject association between momentary negative affect, nicotine craving, and smoking lapse (aim 1) and 2) examine momentary perceived stress and discrimination as moderators of the momentary affect, nicotine craving, and smoking lapse relationship (aim 2) among Black menthol cigarette smokers who do and do not use e-cigarettes. Our central hypothesis is that, at the within-subjects level, higher levels of negative affect than usual will be associated with stronger nicotine cravings, and in turn predict momentary smoking lapse (any v. no smoking) among Black menthol cigarette smokers during a quit attempt. We will recruit 150 Black Arkansan menthol cigarette smokers aged 21-64 who plan to quit smoking in the next 30 days (n=100 cigarette only smokers; n=50 cigarette-e-cigarette dual users) to test our hypothesis on the primary outcome momentary of smoking lapse (any v no smoking). Secondary outcomes include time to smoking lapse, time to smoking relapse, and cigarette consumption. We will also conduct exploratory between-subject analyses by e-cigarette use status. Participants will complete a baseline 7-day pre-quit EMA wave and 7-day post-quit EMA wave, as well as baseline, 1 month, 3-month, and 6-month follow-up online surveys. Smoking status will be verified using exhaled carbon monoxide. This study will fill literary gaps on momentary predictors of smoking lapses among Black menthol smokers and will provide preliminary data for an R01 application. The PI has assembled an outstanding mentorship team who will guide her rigorous training and career development plans. Through formal coursework, summer institutes, hands-on training, and external trainings the PI will increase her competency in EMA/mHealth, randomized behavioral trials, advanced statistics, and tobacco disparities and regulatory science research. Receipt of this K award will strengthen the PI's likelihood of achieving her career goal to become an independent researcher and conduct technology-supported observational studies and interventions that aim to increase successful smoking cessation among socially-disadvantaged smokers.

项目摘要 黑色的吸烟者，其中85％的吸烟薄荷香烟遭受了过多的烟草引起的发病率和 死亡，包括癌症。薄荷醇（v。Non-Menthol）吸烟者，尤其是黑人吸烟者，有更大的 尽管有更多的戒烟尝试，但对尼古丁的依赖性不太可能戒烟。这可能是 部分原因是戒酒引起的积极情绪/情感和尼古丁的渴望下降。但是，那里 关于解释黑色薄荷醇吸烟者吸烟失误的潜在机制的数据有限。 先前的研究使用了生态时刻评估（EMA）来检查负面影响如何（即较差 情绪），尼古丁的渴望（即吸烟的敦促）和上下文因素可以预测实时吸烟的烟雾 时间。了解这些基本机制将有助于我们制定有效的停止干预措施 黑色薄荷醇。为了填补这些关键的研究空白，本研究将使用EMA到1）检查内部 瞬时负面影响，尼古丁渴望和吸烟失误之间的主题关联（AIM 1）和2） 将暂时的感知压力和歧视视为瞬时影响的主持人 渴望和吸烟失误关系（AIM 2）在黑人薄荷醇烟吸烟者中 使用电子烟。我们的中心假设是，在受试者内部，负面影响较高 比平时将与更强烈的尼古丁渴望有关，进而预测瞬时吸烟失误 （任何v。否吸烟）在戒烟尝试中，黑色薄荷烟吸烟者中的吸烟者。我们将招募150黑色 计划在接下来的30天内戒烟的阿肯色薄荷香烟吸烟者21-64岁（n = 100烟） 只有吸烟者； n = 50个香烟烟双用户）测试我们对主要结果的假设 吸烟失误（任何V无吸烟）。次要结果包括抽烟的时间，吸烟时间 复发和消费量。我们还将通过电子烟进行探索性分析 使用状态。参与者将完成7天前EMA波和7天EMA Wave的基线，AS 以及基线，1个月，3个月和6个月的随访在线调查。吸烟状况将得到验证 使用呼出的一氧化碳。这项研究将填补关于吸烟失误的瞬时预测指标的文学空白 在黑色薄荷醇吸烟者中，将为R01应用提供初步数据。 PI组装了 一个杰出的指导团队，将指导她严格的培训和职业发展计划。通过 正式的课程工作，夏季学院，动手培训和外部培训，PI将增加她 EMA/MHealth的能力，随机行为试验，高级统计和烟草差异以及 监管科学研究。获得此K奖的收到将加强PI实现职业生涯的可能性 成为一名独立研究人员并进行技术支持的观察性研究和 旨在增加社会游离吸烟者中成功戒烟的干预措施。