PsycheMERGE: Leveraging electronic health records and genomics for mental health research

PsycheMERGE：利用电子健康记录和基因组学进行心理健康研究

基本信息

批准号：
10339357
负责人：
Lea K Davis
金额：
$ 74.19万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-15 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10339357
关键词：
Address Adult Age Algorithms Attention deficit hyperactivity disorder Biological Bipolar Disorder Childhood Chronic Disease Clinical Clinical Research Communities Complex Computerized Medical Record Data Diagnosis Diagnostic Disease Early Diagnosis Early treatment Eating Disorders Electronic Health Record Electronic Medical Records and Genomics Network Ethnic Origin Genetic Genetic Research Genomic medicine Genomics Gilles de la Tourette syndrome Goals Health Health system Heritability Individual Infrastructure Insurance Coverage Link Machine Learning Major Depressive Disorder Mental Health Mental disorders Methods Modeling Mood Disorders National Human Genome Research Institute Obsessive-Compulsive Disorder Outcome Patients Performance Phenotype Probability Process Psychiatry Psychopathology Public Health Race Research Research Personnel Resources Risk Risk Factors Schizophrenia Site Suicide Surveillance Modeling Testing Training Validation Variant autism spectrum disorder base biobank case control clinical decision support clinical risk clinically relevant comorbidity cost data resource delay sex diagnostic algorithm disability disorder risk effective therapy genome wide association study genome-wide genomic predictors health care service utilization high risk improved indexing mortality neuropsychiatric disorder phenotyping algorithm polygenic risk score precision medicine prediction algorithm predictive modeling psychiatric genomics random forest risk prediction sex support tools support vector machine

项目摘要

Neuropsychiatric disorders are the leading causes of disability in the US and are associated with increased mortality (e.g. through suicide and associations with chronic diseases and their risk factors). Evidence suggests that early detection and treatment of psychiatric illness is essential to improving long-term outcomes and may even modify illness trajectories at a biological level. Unfortunately, a substantial proportion of patients undergo a long diagnostic odyssey before receiving an appropriate diagnosis and initiating effective treatment. Efforts to improve surveillance for emerging or occult psychopathology are often complex, costly, and have limited yield. Thus, there is an urgent public health need to improve clinical decision support for the early detection of psychiatric disorders in clinical settings. The growing availability of large-scale biobanks linking EHRs to biospecimens has created a powerful, but still relatively untapped, opportunity for psychiatric research. In 2007, the NHGRI organized the Electronic Medical Records and Genomics (eMERGE) network which has brought together investigators around the U.S. to facilitate EHR-based genomic research and the implementation of genomic medicine. To date, however, EHR-based risk prediction and genomics have not been widely leveraged for psychiatric research. To address this gap, we have created a new, large-scale collaborative consortium—PsycheMERGE—which leverages the resources and existing infrastructure of the eMERGE network, the Psychiatric Genomics Consortium (PGC), and local EHR and biobank resources. In this proposal, we aim to: (1) phenotypically and genomically validate and harmonize case and control phenotypes across multiple disorders (2) build clinically-useful risk surveillance models for mood disorders that also leverage cross-institutional genomewide data, and (3) examine whether EHR- and genomic-based risk profiles are associated with clinically-relevant health outcomes. We will further use these risk profiles to examine disparities in diagnostic delay by age, sex and race/ethnicity. The resulting diagnostic and risk prediction algorithms will be made available to the scientific community through the eMERGE network. Successful completion of these aims would represent a major advance in demonstrating the utility of EHR resources for precision medicine approaches to psychiatry, provide the first step toward clinical decision support tools that can be implemented within health systems, and create an invaluable resource for the scientific community.

神经精神疾病是美国残疾的主要原因，与增加有关死亡率（例如，通过自杀和与慢性疾病及其危险因素的关联）。证据表明早期发现和治疗精神病对于改善长期结局至关重要甚至可以在生物学水平上修改疾病轨迹。不幸的是，很大一部分患者在接受适当的诊断并启动有效治疗之前，要经历长时间的诊断奥德赛。改善新兴或神秘心理病理学监视的努力通常是复杂，昂贵的，并且产量有限。这是紧迫的公共卫生需要改善早期的临床决策支持在临床环境中检测精神疾病。大规模生物库链接的可用性不断增长 EHRS到生物测量已经创造了一个有力但相对尚未开发的精神病机会的机会研究。 2007年，NHGRI组织了电子病历和基因组学（Emerge）网络这使美国各地的调查人员聚集在一起，以促进基于EHR的基因组研究和基因组医学的实施。但是，迄今为止，基于EHR的风险预测和基因组学尚未被广泛杠杆化用于精神病研究。为了解决这一差距，我们创建了一个新的大规模合作联盟（Psychemerge） Emerge Network，精神病基因组学联盟（PGC）以及本地EHR和生物库资源。在这个提案，我们的目的是：（1）在表观上和基因组上验证并协调案例和控制表型跨多种疾病（2）为情绪障碍建立临床可用性的风险监视模型利用跨机构全基因组的数据，以及（3）检查基于EHR和基因组的风险概况是否与临床上的健康结果有关。我们将进一步使用这些风险概况来检查年龄，性别和种族/种族的诊断延迟差异。由此产生的诊断和风险预测算法将通过出现的网络提供给科学界。成功的这些目标的完成将代表证明EHR资源实用性的重大进步精神病学的精确医学方法，提供迈向临床决策支持工具的第一步可以在卫生系统中实施，并为科学界创造宝贵的资源。