Modulating prefrontal circuits underlying behavioral flexibility in OCD: a TMS study

调节强迫症行为灵活性背后的前额叶回路：一项 TMS 研究

基本信息

批准号：
10338144
负责人：
Sarah Lynn Garnaat
金额：
$ 27.6万
依托单位：
BUTLER HOSPITAL (PROVIDENCE, RI)
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-01 至 2022-12-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10338144
关键词：
Acute Affect Anatomy Anterior Area Award Base of the Brain Behavior Behavior Control Behavioral Brain Brain region Centers of Research Excellence Chronic Clinical Corpus striatum structure Data Correlations Development Disease Dorsal Enrollment Foundations Frequencies Functional Magnetic Resonance Imaging Functional disorder Goals Impairment Individual Intervention Investigation Knowledge Measures Mentors Obsessive-Compulsive Disorder Participant Patients Pattern Performance Play Population Prefrontal Cortex Procedures Process Research Research Project Grants Rest Reversal Learning Role Staff Development System Testing Training Transcranial magnetic stimulation Translations Treatment outcome Ventral Striatum Work age group base behavior change behavioral impairment behavioral outcome cingulate cortex cognitive control cognitive task compulsion disorder control flexibility healthy volunteer improved neural circuit neural patterning neuroimaging neuropsychiatric disorder neuropsychiatry neuroregulation recruit relating to nervous system repetitive transcranial magnetic stimulation response

项目摘要

PROJECT SUMMARY/ABSTRACT The primary goal of this proposed COBRE Center for Neuromodulation Project is to elucidate neural circuits underlying impairments in behavioral flexibility in OCD, using transcranial magnetic stimulation as a probe of the system and fMRI to measure functional changes within neural circuitry implicated in behavioral (in)flexibility in obsessive-compulsive disorder (OCD). OCD is a chronic and impairing neuropsychiatric disorders associated with impairments in behavioral flexibility – most notably, the compulsions which are a hallmark of the disorder. Patients with OCD also show impaired behavioral flexibility on a range of experimental tasks (e.g., set-shifting, task-switching, reversal learning). Moreover, neuroimaging findings in OCD routinely show abnormal patterns of activation during tasks probing behavioral flexibility. The proposed research project will use slow frequency (1-Hz) rTMS to probe dysfunctional circuitry, targeting frontal pole, an area involved in higher level cognitive control processes which likely plays a key role in coordination between multiple neural circuits involved in behavioral flexibility and which shares structural and functional connections to circuitry implicated in behavioral inflexibility in OCD. We aim to test whether (1) slow frequency (1-Hz) rTMS to frontal pole can affect functional changes within circuits showing abnormal functioning during behavioral flexibility in OCD, (2) whether rTMS targeting this circuitry can affect behavioral changes in a population with deficits in behavioral flexibility, and (3) whether circuit functioning relates to behavioral performance following rTMS. While a number of studies have shown abnormal neural circuit functioning during behavioral flexibility tasks in OCD, to our knowledge, this will be the first to move beyond correlational findings to directly examine changes to circuit functioning following a probe of the system using TMS. The long-term goal of this work is to inform target identification for development of neurocircuit-based interventions which may improve treatment outcomes for those with OCD.

项目概要/摘要 COBRE 神经调节中心项目的主要目标是阐明神经回路使用经颅磁刺激作为强迫症行为灵活性的潜在损害该系统和功能磁共振成像测量与行为灵活性有关的神经回路内的功能变化强迫症 (OCD) 是一种慢性且损害性的神经精神疾病。与行为灵活性受损有关——最值得注意的是，强迫行为是行为灵活性的标志强迫症患者在一系列实验任务中也表现出行为灵活性受损。（例如，设定转移、任务转换、逆向学习）此外，强迫症的神经影像学结果通常显示。拟议的研究项目将在探索行为灵活性的任务期间出现异常的激活模式。使用慢频 (1-Hz) rTMS 来探测功能失调的电路，针对额极，这是一个涉及的区域更高水平的认知控制过程可能在多个神经元之间的协调中发挥关键作用涉及行为灵活性并与电路共享结构和功能连接的电路我们的目标是测试 (1) 额叶的慢频率 (1-Hz) rTMS 是否与强迫症的行为僵化有关。极可以影响电路内的功能变化，在行为灵活性期间表现出异常功能强迫症，(2) 针对该电路的 rTMS 是否可以影响具有缺陷的人群的行为变化行为灵活性，以及 (3) 回路功能是否与 rTMS 后的行为表现相关。虽然许多研究表明，在行为灵活性任务中，神经回路功能异常据我们所知，OCD 将是第一个超越相关发现直接检查变化的项目使用 TMS 探测系统后的电路功能这项工作的长期目标是提供信息。确定目标以开发基于神经回路的干预措施，从而改善治疗强迫症患者的结果。