Animal Models of Digestive Disease Core

消化系统疾病动物模型核心

基本信息

批准号：
10337322
负责人：
Suzanne L Craig
金额：
$ 21.2万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-03 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10337322
关键词：
American Animal Experimentation Animal Model Animals Area Biological Products Biomedical Research Caring Catheters Cells Centers of Research Excellence Chemicals Cirrhosis Complex Core Facility Data Diet Digestive System Disorders Disease model Educational workshop Environment Extramural Activities Faculty Feedback Fibrosis Funding Future Generations Genetic Germ-Free Gnotobiotic Housing Individual Inflammation Knowledge Laboratories Laboratory Animals Laboratory mice Ligation Liver diseases Malignant Neoplasms Medical Mentors Mentorship Metabolic Diseases Modeling Modification Mus Needs Assessment Operative Surgical Procedures Organoids Partial Hepatectomy Performance Procedures Pump Research Research Infrastructure Research Personnel Research Project Grants Resources Services South Carolina Surveys Training Universities Update Work animal facility animal resource base bile duct driving force experience follow-up gastrointestinal system implantation in vivo in vivo Model meetings member microbiome microbiome research microorganism tool

项目摘要

Animal Models of Digestive Disease Core – Project Summary The objective of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enhance research infrastructure and expand research capacity to enable outstanding and collaborative biomedical research in digestive and liver diseases. We wish to establish and sustain the CDLD as the driving force for digestive and liver diseases research at the Medical University of South Carolina (MUSC). We further envision that the MUSC CDLD will become a major focal point for digestive and liver diseases in the state of South Carolina, becoming a hub for trainees and established investigators alike. The topic of this COBRE is particularly relevant given the enormous impact of digestive and liver diseases on a broad range of Americans, including the citizens of South Carolina. Performance of digestive disease research requires utilization of unique and complex models of disease. Thus, we have developed a Core intended to specifically provide the COBRE in Digestive & Liver Diseases (CDLD) with a distinctive, unified, and skilled core facility that provides access to essential animal models and guidance on research project planning and implementation. The proposed core will leverage existing resources and expertise within the MUSC Division of Laboratory Animal Resources (DLAR) in order to efficiently develop new capabilities that focus on producing in vivo models of digestive disease. Core leaders will offer CDLD Junior Investigators (JIs) specialized knowledge, mentorship and training on animal models so that they obtain sufficient, high quality data for their projects, which will then form the basis of their successful competition for future independent extramural funding. Supporting JIs’ research is the a objective for the AMDDC; however, all investigators at MUSC will have access to the models, resources, and training the Core provides. To achieve the stated objective, the AMDDC will be composed of three distinct but interactive components as follows: 1) Animal models of digestive and liver diseases, 2) A gnotobiotics facility, and 3) A focused and extensive training and mentoring component. Members of this core are skilled and highly experienced, supporting the generation of high quality data. !

消化系统疾病动物模型核心——项目总结消化与肝脏疾病 (CDLD) 生物医学卓越研究中心 (COBRE) 的目标是加强研究基础设施和扩大研究能力，以实现杰出和协作我们希望建立并维持 CDLD 作为驱动力。南卡罗来纳医科大学（MUSC）消化和肝脏疾病研究的力量我们进一步。预计 MUSC CDLD 将成为该州消化和肝脏疾病的主要焦点南卡罗来纳州，成为实习生和资深调查员的中心本次 COBRE 的主题是。鉴于消化系统和肝脏疾病对广大美国人的巨大影响，这一点尤其重要，包括南卡罗来纳州的公民。消化系统疾病研究的进行需要利用独特且复杂的疾病模型。我们开发了一个核心，旨在专门提供消化道和肝脏疾病 (CDLD) 中的 COBRE 拥有独特、统一且技术精湛的核心设施，可提供基本的动物模型和指导拟议的核心将利用现有资源和实施。 MUSC 实验动物资源部 (DLAR) 内的专业知识，以便有效地开发新的专注于生产消化系统疾病体内模型的能力核心领导者将提供 CDLD Junior。研究人员 (JI) 动物模型方面的专业知识、指导和培训，以便他们获得为他们的项目提供充足、高质量的数据，这将成为他们成功竞争的基础然而，AMDDC 的目标是支持 JI 的未来独立外部资助； MUSC 的研究人员将能够访问核心提供的模型、资源和培训。为了实现既定目标，AMDDC 将由三个不同但互动的部分组成：如下：1) 消化系统和肝脏疾病的动物模型，2) 一个无菌设施，以及 3) 一个集中和该核心成员拥有广泛的培训和指导，技术精湛，经验丰富，支持高质量数据的生成。！