ACC BioRepository

ACC生物样本库

基本信息

批准号：
10330978
负责人：
MICHAEL D FELDMAN
金额：
$ 0.21万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-01-15 至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10330978
关键词：
Address Air Conditioning Basic Science Biological Specimen Banks Biological Specimen database Biopsy Biopsy Specimen Blood Blood specimen Cancer Center Cancer Center Support Grant Cell Survival Cells Clinical Data Clinical Investigator Clinical Pathology Clinical Protocols Clinical Research Clinical Sciences Clinical Trials Collaborations Collection Consent Consultations Coupled DNA Data Development Disease Electronic Health Record Ensure Equipment and supply inventories Excision Farm Freezing Genotype Home Hospitals Human Image Guided Biopsy Immunosuppression Industry Interventional radiology Laboratories Lead Link Location Malignant Neoplasms Medicine Mission Monitor Nature Neoplasm Circulating Cells Normal tissue morphology Operative Surgical Procedures Outcome Pathologic Pathology Patients Pennsylvania Plasma Population Population Sciences Precancerous Conditions Procedures Process Proteins Protocols documentation Pumpkins Radiology Specialty Reporting Research Research Personnel Resource Sharing Resources Review Committee Sampling Security Serum Services Side Specimen System Time Tissue Banks Tissue Sample Tissues Translational Research Tumor Tissue University Hospitals Utilization Review Work biobank blood product cancer imaging cancer surgery clinical care cohort cost effectiveness data registry exome exome sequencing exosome extracellular vesicles genomic data informatics infrastructure interest liquid biopsy medical schools member programmed cell death ligand 1 programs prospective radiologist remote monitoring repository sample archive sample collection sensor tumor tumor DNA tumor registry vapor

项目摘要

PROJECT SUMMARY – Abramson Cancer Center BioRepository (ABR) The Abramson Cancer Center BioRepository (ABR) is a shared core laboratory comprised of four integrated components that together enable the collection of tumor and normal tissue samples from surgical resections and radiology guided biopsy (supporting clinical trials), blood collections (buffy coats, serum and plasma), and liquid biopsy (ctDNA, CTC, soluble proteins and extra-cellular vesicles). This integrated Shared Resource leverages uniformity of quality across a breadth of biosamples and enhanced efficiencies gained through use of a universal consent. The tumor tissue, blood collection and liquid biopsy material collections are supported by a new prospective universal consent allowing for collection of blood and tissue (at time of surgery), patient re-contact, “omics” study of the collected biosamples, and linkage to electronic health records for outcome- related translational research. Biosample inventory data are managed through Open Specimen, a commercial biosample database on the tissue side, and Pumpkin, a home-grown system for blood sample processing – both well-suited to handle large volume sample collections and archiving. Penn Medicine has a centralized informatics infrastructure (PennOmics v2) composed of an enterprise DataLake that combines EHR data, tumor registry data, and genomic data (germline and somatic studies) that links to stored biosample inventories across our biosample database (Open Specimen and Pumpkin) that allows for cohort exploration and requesting biosamples from these cohorts. Biosamples are stored in two new freezer farms recently constructed at the Perelman School of Medicine in either -80 freezers (buffy coats, plasma and serum) or LN2 vapor (tissue or viable cells). Both freezer farms have completely redundant air conditioning, electric and central monitoring resources including remote monitoring and alarms with O2 security sensors to support LN2 vapor storage. ABR is tightly coupled with a larger institutional biosample repository (Penn Medicine Biobank) which has grown to >60K patient blood samples, including whole exome sequencing and genotyping on >15K of these patients. The Penn Medicine Biobank is a broad effort across Penn Medicine that seeks to collect blood and tissues across a wide range of both normal patients as well as patients with a variety of diseases. The ABR Shared Resource is directed by Dr. Michael Feldman, who has been leading the tumor tissue and blood repository since its inception in 2005. Ms. Joellen Weaver, Technical Director, has worked in biobanking for 20 years. ACC members accounted for 43 of 62 investigators (69%) using this Shared Resource during the most recent reporting period (07/01/18-06/30/19). ABR has supported high-impact research, e.g. changing the fundamental understanding of immune suppression in tumors via PDL1-carrying exosomes (Chen et al., Nature, 2018). ABR facilitates access to a wide variety and number of biospecimens for ACC members across the basic, clinical, and population science Programs, addressing the changing scientific needs of ACC membership and increased research demand for tissue and blood products.

项目摘要 - 艾布拉姆森癌症中心生物座席（ABR）艾布拉姆森癌症中心生物座席（ABR）是一个共享的核心实验室，完成了四个集成的可以从外科手术切除术的肿瘤和正常组织样品的组件共同收集和放射学指导活检（支持临床试验），血液收集（Buffy Coats，血清和血浆）和液体活检（CTDNA，CTC，固体蛋白质和细胞外蔬菜）。这个集成的共享资源在宽阔的生物样本中利用质量统一，并通过使用提高效率普遍同意。支持肿瘤组织，血液收集和液体活检材料收集通过新的前瞻性普遍同意，允许收集血液和组织（手术时），患者重新连接，对收集的生物样本的“ OMICS”研究，以及与电子健康记录的联系相关的翻译研究。生物样品清单数据是通过广告开放标本来管理的组织侧的生物样品数据库和南瓜，这是一种用于血液样本处理的本土系统 - 两者都非常适合处理大量的样品集和归档。宾夕法尼亚医学有一个集中的信息基础架构（pennomics V2）由结合EHR数据的企业数据组成，肿瘤注册表数据和基因组数据（种系和体细胞研究），与存储的生物样品库存联系在我们的生物样品数据库（开放标本和南瓜）中，可以进行队列探索和从这些同类中要求生物样本。生物样本最近存储在两个新的冰柜农场中在-80个冰柜（Buffy Coats，等离子体和血清）或LN2的Perelman医学院建造蒸气（组织或活细胞）。两个冰柜农场都有完全冗余的空调，电动和中央监控资源，包括远程监控和使用O2安全传感器的警报，以支持LN2 蒸气存储。 ABR与较大的机构生物样品存储库（Penn Medicine Biobank）紧密结合已经长达到> 60k的患者血液样本，包括整个外显子组测序和> 15k的基因分型这些患者。 Penn Medicine Biobank是宾夕法尼亚医学的广泛努力，试图收集广泛的正常患者以及各种疾病的患者的血液和组织。 ABR共享资源由一直领导肿瘤组织的Michael Feldman博士指导自2005年成立以来，血液存储库。 20年。 ACC成员使用此共享资源在62名调查人员中有43位（69％）占最近的报告期（07/01/18-06/30/19）。 ABR支持高影响研究，例如更改通过PDL1携带外泌体对肿瘤中免疫抑制的基本了解（Chen等，大自然，2018年）。 ABR收藏夹访问ACC成员的各种各样的生物测量和数量基本，临床和人口科学计划，以满足ACC不断变化的科学需求成员资格并增加了组织和血液产品的研究需求。