MI-CARES: The Michigan Cancer and Research on the Environment Study

MI-CARES：密歇根癌症与环境研究

基本信息

批准号：
10336238
负责人：
Dana Dolinoy
金额：
$ 111.07万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10336238
关键词：
Address Adult African Air Pollution Animal Feed Area Awareness Behavior Biological Aging Biological Assay Biological Markers Birth Records Blood Body mass index Carcinogens Cell Aging Chemicals Cities Collection Communication Communities DNA Methylation Data Data Collection Enrollment Environment Environmental Carcinogens Environmental Exposure Environmental Impact Environmental Pollutants Environmental Pollution Ethnic Origin Ethnic group Exposure to Feasibility Studies Garbage Geographic Locations Goals Government Health Health protection Heavy Metals Hispanics Individual Industrialization Inflammation Institutional Review Boards Laboratories Laboratory Study Lead Life Cycle Stages Life Style Location Malignant Neoplasms Measurement Measures Mediating Metabolic Pathway Metals Michigan Modeling Modification Morbidity - disease rate Nested Case-Control Study Noise Oils Participant Patient Self-Report Perinatal Perinatal Exposure Phase Polybrominated Biphenyls Population Predisposition Private Enterprises Procedures Protocols documentation Public Health Questionnaires Race Recording of previous events Reporting Research Risk Rivers Safety Saliva Sampling Socioeconomic Status Spottings Steel Testing Toxin Water Supply Woman Xenobiotics aged anticancer research base cancer biomarkers cancer risk carcinogenicity case control coal-fired power plant cohort community engagement contaminated water design environment related cancer epigenetic regulation ethnic diversity experience follow-up immune function lead contamination lifestyle factors member men metabolic profile metabolomics metropolitan mortality novel personal care products racial and ethnic recruit sociodemographics

项目摘要

Many communities around the U.S. have been failed by private enterprise and governmental stewardship in protecting their local environments and thus health. The goal of this proposal is to establish MI-CARES: The Michigan Cancer and Research on the Environment Study to describe and quantify the impact of known and novel environmental exposures on cancer risk. With MI-CARES we will examine well-established environmental carcinogens such as air pollution and heavy metals, but also focus on less characterized exposures including per- and polyfluoroalkyl substances (PFAS), noise, and chemicals in personal care products for which there are urgent needs to assess carcinogenicity. As disparities in these exposures are common by geographic region, socioeconomic status, race/ethnicity, and lifestyle, research is required to understand how these factors impact the relationships between the environment and cancer risk. Michigan (MI) is an ideal location to carry out research on environmental exposures and cancer risk. Michiganders have experienced a tragic suite of environmental exposures ranging from contaminated animal feed with polybrominated biphenyls (PBBs) in the 1970s, to the lead contamination of Flint’s water supply, and the highest known PFAS levels of any state. The “Tri-Cities” area of metro Detroit, a predominantly Black and Hispanic community, is the most polluted region in Michigan and high-ranking in the entire U.S. These exposures in MI are profound and the strong history of community engagement makes MI-CARES feasible. In this project, we hypothesize that environmental exposures impact inflammation, cellular aging, epigenetic regulation, and immune function to ultimately increase cancer risk. To investigate this hypothesis, we propose to establish MI-CARES, a racially/ethnically diverse cohort of 100,000 cancer-free men and women aged 25-44 residing in environmental injustice hotspots in MI: the Detroit metropolitan area, Flint, Grand Rapids, Kalamazoo, Lansing, and Saginaw. We will recruit equal numbers of Black, Hispanic, Middle Eastern and North African (MENA), and White participants; all but the latter are underrepresented in environmental and cancer research. Questionnaire, community-level data, and birth records will be collected for all participants using a life course approach to capture data during critical windows of susceptibility. Data collection will include information on individual sociodemographics, residential histories, health, and lifestyle. Lifetime exposures to environmental pollutants will be ascertained through questionnaire, residential proximity-based measures or models. In addition, biospecimens (blood spots and saliva) will be collected on all participants. Within MI-CARES, we will form an enhanced measurement cohort (n=1,000 cancer- free cohort members) and a nested case-control sample (n=250 cancer cases and 250 matched cancer-free cohort controls) in whom a comprehensive laboratory-based exposure and intermediate cancer biomarker assessment will be conducted, including PFAS, metals, untargeted metabolomics, DNA methylation, and inflammation biomarkers.

美国的许多社区都因私营企业和政府管理而失败保护他们的本地环境，从而健康。该提议的目的是建立Mi-cares：密歇根州癌症和环境研究研究，以描述和量化已知和的影响新的环境暴露于癌症风险。使用MI-CARES，我们将检查建立良好的环境诸如空气污染和重金属之类的致癌物，但也集中于特征性较低的暴露人类护理产品中的各种和多氟烷基物质（PFA），噪声和化学物质迫切需要评估致癌性。由于这些暴露的差异是地理区域常见的，因此社会经济地位，种族/种族和生活方式，需要研究才能了解这些因素如何影响环境与癌症风险之间的关系。密歇根州（MI）是执行的理想场所关于环境暴露和癌症风险的研究。密歇根州经历了一套悲惨的套房环境暴露范围从污染的动物饲料中用多溴双苯基（PBB）的污染动物饲料 1970年代，弗林特供水的铅污染以及任何州已知最高的PFA水平。这底特律大都会地区的“三城市”地区是一个主要是黑人和西班牙裔社区，是污染最严重的地区密歇根州和整个美国的高级排名社区参与使Mi-Cares可行。在这个项目中，我们假设环境暴露会影响炎症，细胞衰老，表观遗传调节和免疫功能，以最终增加癌症风险。为了研究这一假设，我们建议建立Mi-cares，这是一种种族/种族多样的在MI中居住在环境损伤热点中的100,000名无癌的男性和女性的队列：底特律都会区，弗林特，大急流城，卡拉马祖，兰辛和萨吉诺。我们将同等招募黑人，西班牙裔，中东和北非（MENA）以及白人参与者的数量；除了后者之外在环境和癌症研究中的人为不足。问卷，社区级数据和出生将使用生命课程方法为所有参与者收集记录，以捕获关键窗口中的数据易感性。数据收集将包括有关单个社会人口统计学，居民历史的信息，健康和生活方式。通过问卷调查，将确定对环境污染物的终身暴露居民基于接近度的措施或模型。此外，生物测量（血点和唾液）将是收集所有参与者。在Mi-cares中，我们将形成增强的测量队列（n = 1,000个癌症 - 免费队列成员）和嵌套的病例对照样本（n = 250例癌症病例和250个匹配的无癌症队列控制），其中全面的基于实验室的暴露和中间癌症生物标志物评估将进行，包括PFA，金属，未靶向代谢组学，DNA甲基化和炎症生物标志物。