Multi-site Study of Dyslexia

阅读障碍的多中心研究

• 批准号: 10328238
• 负责人: MARK A ECKERT
• 金额: $ 28.14万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-03 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328238
• 关键词: Achievement; Address; Affect; Anatomy; Animal Model; Anterior; Auditory area; Autopsy; Behavioral; Behavioral Genetics; Brain; Brain region; Cerebrum; Child; Communities; Comprehension; Computer software; Consensus; Data; Data Set; Databases; Development; Dyslexia; Ensure; Female; Funding; Genes; Genetic; Genetic Risk; Heterogeneity; Hippocampus (Brain); Image; Image Analysis; Impairment; Incentives; Inferior frontal gyrus; Influentials; Infrastructure; Insula of Reil; Language; Language Development; Link; Literature; Manuals; Maps; Measurement; Measures; Meta-Analysis; Methods; Neurons; Oral; Parietal Lobe; Pathway interactions; Pattern; Persons; Physical shape; Procedures; Quality Control; Reading Disabilities; Research; Research Personnel; Resolution; Resources; Risk; Sample Size; Sampling; Site; Speech Sound; Structure; Sylvius fissure; Testing; base; brain morphology; case control; cloud based; collaborative approach; data de-identification; data sharing; data tools; design; developmental disease; imaging study; language impairment; large datasets; male; migration; neurodevelopment; neurogenetics; neuroimaging; novel; phonology; relating to nervous system; risk prediction; risk variant; sex; software development; tool

PROJECT SUMMARY/ABSTRACT [The proposed research tests the hypothesis that atypical cerebral symmetries increase the risk for dyslexia through the expression of dyslexia-related genes that are known to regulate brain development.] While there were early promising findings linking planum temporale symmetry to dyslexia, study limitations due to small sample size, inconsistent measurement methods, and varied behavioral and genetic profiles of the subjects produced inconsistent results. [Here we examine planum temporale and other cerebral symmetries associated with dyslexia]. We address the limitations of previous studies by using a large dataset of existing genetic, neuroimaging, and behavioral data, as well as multi-site methods that we developed in the current funding period that make it possible to address dyslexia hypotheses with large multisite datasets. We have demonstrated the ability to deal with missing data, varied image acquisitions, and the behavioral heterogeneity of dyslexia samples that is influenced by sampling approaches. [Specific Aim 1 is to test the hypothesis that atypical cerebral asymmetries are observed for specific reading disability profiles, which are theoretically and empirically-grounded and map to different genetic risks. Specific Aim 2 is to examine the degree to which specific genetic risk variants for dyslexia influence the development of cerebral asymmetries. Specific Aim 3 is to develop the cloud-based infrastructure to provide investigators with secondary data for use in their studies and to replicate our findings (e.g., cerebral asymmetry measures related to dyslexia). The results will provide a consensus on the cerebral asymmetry hypothesis for dyslexia because of our large dataset and collaborative approach, provide behavioral neurogenetic explanations for dyslexia, and provide resources to the research community to advance our understanding of dyslexia and other developmental disorders.]

项目概要/摘要 [拟议的研究检验了非典型大脑对称性会增加患此病的风险的假设 阅读障碍是通过阅读障碍相关基因的表达来调节大脑发育的。] 早期有希望的发现将颞平面对称性与阅读障碍联系起来，但由于研究的局限性 小样本量、不一致的测量方法以及不同的行为和遗传特征 受试者产生不一致的结果。 [在这里我们检查颞平面和其他大脑对称性 与阅读障碍有关]。我们通过使用现有的大型数据集来解决以前研究的局限性 遗传、神经影像和行为数据，以及我们当前开发的多位点方法 资助期使利用大型多站点数据集解决阅读障碍假设成为可能。我们有 展示了处理缺失数据、不同图像采集和行为异质性的能力 受采样方法影响的阅读障碍样本。 [具体目标 1 是检验以下假设： 观察到特定阅读障碍特征的非典型大脑不对称性，这在理论上和 以经验为基础并映射到不同的遗传风险。具体目标 2 是检验 阅读障碍的特定遗传风险变异会影响大脑不对称的发展。具体目标 3 是开发基于云的基础设施，为研究人员提供用于研究的二手数据 并复制我们的发现（例如，与阅读障碍相关的大脑不对称测量）。结果将提供 由于我们的大量数据集和协作，就阅读障碍的大脑不对称假说达成共识 方法，提供阅读障碍的行为神经遗传学解释，并为研究提供资源 社区以增进我们对阅读障碍和其他发育障碍的理解。]