HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUES

高场 MRI 和迷路：前庭刺激和新成像技术

• 批准号: 10321281
• 负责人: Bryan Kevin Ward
• 金额: $ 19.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10321281
• 关键词: Address; Anatomy; Animals; Asphyxia; Aspiration Pneumonia; Atelectasis; Award; Biomedical Engineering; Chinchilla (genus); Clinical; Conscious; Curiosities; Data; Development; Diagnosis; Disease; Dizziness; Edema; Endolymph; Environment; Ethics; Functional disorder; Funding; Future; Goals; Grant; Hair Cells; Head; Head and Neck Surgery; Head and neck structure; Health; Human; Image; Imaging Techniques; Interdisciplinary Study; K-Series Research Career Programs; Knowledge; Labyrinth; Lead; Liquid substance; MRI Scans; Magnetic Resonance Imaging; Magnetism; Mammals; Meniere' s Disease; Mentors; Methods; Movement; Nausea; Nausea and Vomiting; Neurology; Noise; North America; Otolaryngology; Otology; Participant; Pathologic Nystagmus; Pathology; Patients; Pattern; Performance; Phase; Physics; Physiological; Positional Vertigo; Positioning Attribute; Problem Solving; Prospective Studies; Protocols documentation; Publishing; Radiology Specialty; Research; Research Personnel; Resolution; Safety; Scanning; Signal Transduction; Structure; Supination; Surface; System; Target Populations; Techniques; Technology; Testing; Time; Training; Universities; Vertigo; Vestibular Labyrinth; Vestibule; Work; anatomic imaging; career; cellular transduction; clinical practice; cost; cost effective; experience; fluid flow; high resolution imaging; human imaging; imaging modality; improved; in vivo; inner ear diseases; magnetic field; medical schools; membranous labyrinth; nervous system disorder; novel; professor; programs; recruit; responsible research conduct; risk minimization; skills; temporal measurement; vector; ward

ABSTRACT Dr. Bryan Ward is an assistant professor in the department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine, where he is dedicating his clinical practice to vestibular disorders, otology and neurotology. He is seeking a mentored career development award in order to fill knowledge gaps in imaging of the inner ear using MRI. His long-term goal is establishing an independent research program that is devoted to using imaging to improve the diagnosis and treatment of patients with dizziness and imbalance. The candidate proposes expanding on his prior work studying the physiologic effects of strong magnetic fields on the inner ear vestibular system to imaging the fluid flow in the labyrinth of healthy chinchillas and humans. The training plan immerses Dr. Ward in the multidisciplinary research and clinical environments in the departments of radiology, neurology, biomedical engineering and otolaryngology at the Johns Hopkins University School of Medicine. Specific training goals include: (1) receive training in the physics of MRI and how images are acquired, (2) complete training in MRI safety and performing prospective studies using imaging modalities, (3) pursue additional training in the ethical and responsible conduct of research, and (4) integrate his clinical training in vestibular disorders with this knowledge as he develops into an independent investigator. High magnetic field MRIs can increase spatial and temporal resolution of images as a result of increased signal-to-noise ratio; however, these MRI machines also cause dizziness and vertigo in humans. We previously showed that all healthy humans have nystagmus in an MRI and hypothesized that this is due to a Lorentz force occurring in the labyrinth. The specific aims of the proposed research are to: (1) test the hypothesis that a Lorentz force causes fluid flow that can be observed in vivo using phase contrast/flow imaging in MRI, (2) to develop and implement a cost-effective countermeasure that minimizes the risk of vertigo in high-strength MRI fields, and (3) to image the human labyrinth in 7T and 3T MRI combining anatomic and flow imaging sequences. The study will involve chinchillas in aim 1 and the recruitment of healthy human participants in aims 2 and 3. Completion of the proposed research plan will provide evidence for the cause of dizziness in strong MRI, a low-cost method to mitigate the effects of dizziness in an MRI regardless of the magnetic field strength, and support that improved MRI can provide higher resolution images of the labyrinth. At the conclusion of this award, the candidate will be well-positioned to compete successfully for funding, having acquired relevant knowledge and skills to become a leader in using high-strength MRI to identify new vestibular pathophysiology and improve diagnosis of common conditions that cause dizziness and vertigo.

抽象的 布莱恩·沃德（Bryan Ward）博士是耳鼻喉科和颈部手术系的助理教授 约翰·霍普金斯医学院（Johns Hopkins Medicine 和神经病学。他正在寻求指导的职业发展奖，以填补知识空白 使用MRI对内耳进行成像。他的长期目标是建立一个独立的研究计划 致力于使用成像来改善头晕和失衡患者的诊断和治疗。这 候选人提议扩大他的先前工作，以研究强磁场的生理影响 内耳的前庭系统，以对健康的龙猫和人类迷宫中的流体进行成像。这 培训计划将沃德博士浸入部门的多学科研究和临床环境中 约翰·霍普金斯大学学校放射学，神经病学，生物医学工程和耳鼻喉科学院 药品。具体的培训目标包括：（1）接受MRI物理学的培训以及图像的方式 获得，（2）使用成像方式进行MRI安全性和进行前瞻性研究的完整培训，（3） 在道德和负责任的研究中进行其他培训，以及（4）整合他的临床 当他发展成为独立研究者时，他对前庭疾病的培训。 高磁场MRI可以增加图像的空间和时间分辨率，导致图像的增加 信噪比；但是，这些MRI机器也会在人类中引起头晕和眩晕。我们 以前表明，所有健康的人都有MRI中的眼球震颤，并假设这是由于A 在迷宫中出现的洛伦兹力。拟议研究的具体目的是：（1）测试 假设洛伦兹力会导致流体流动，可以在体内观察到使用相位对比/流动 在MRI中进行成像，（2）开发和实施具有成本效益的对策，以最大程度地减少眩晕的风险 在高强度的MRI场中，（3）在7T和3T MRI中对人迷宫进行图像结合解剖学 和流成像序列。这项研究将涉及丁香糖在AIM 1和健康人类的招募 目标2和3的参与者。拟议的研究计划的完成将为原因提供证据 强烈MRI的头晕，这是一种低成本方法，可以减轻MRI中头晕的影响 磁场强度和改善的MRI支持可以提供迷宫的更高分辨率图像。 在该奖项结束时，候选人将有充分的位置以成功竞争资金， 获得了相关的知识和技能，成为使用高强度MRI识别新的领导者 前庭病理生理学并改善引起头晕和眩晕的常见状况的诊断。