Novel edible cellulose microcarriers for the cultured meat industry

用于培养肉行业的新型食用纤维素微载体

• 批准号: 10048301
• 金额: $ 53.31万
• 依托单位: NATURBEADS LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10048301
• 关键词: Novel; edible; cellulose; microcarriers; cultured

Seventy years ago, Churchill famously said: 'We shall escape the absurdity of growing a whole chicken in order to eat the breast or wing, by growing these parts separately under a suitable medium.' Cultured meat is a healthier (less antibiotics), more ethical (better animal welfare), more efficient (better use of land) and sustainable way to produce meat and meet the protein demand of a growing population. The market for cultured meat is estimated to reach £30B in 2030 (McKinsey).To scale the production process there is a need for enabling technologies, like edible microcarriers that allow anchorage, proliferation and differentiation of stem cells, and then harvesting of the final product. Naturbeads cellulose beads production process (currently scaling from pilot to demo plant) allows customizing the properties of the cellulose beads to promote cells attachment, growth, and differentiation. We have already developed a prototype that shows performance in cell culture plates (2D) superior to commercially available scaffolding that are currently only used in R&D due to their prohibitive costs. With this project we aim to move from proof of concept to a commercial prototype that we can sell by the end of the project for industrial R&D to lock in customers for scaled up production. Naturbeads will work together with Cellular Agriculture to test the performance of the cellulose microcarriers in bioreactors (3D) to optimize the parameters for cell proliferation, differentiation in stirred tanks, and cell detachment.Naturbeads carriers are made of cellulose a natural, edible, and biocompatible biopolymer, that can be sourced sustainably from forestry groups part of PEFC (Programme for the endorsement of Forest Certification). It is also inexpensive, offering a low-cost scaffolding structure with the potential to lower production costs of culture meat, allowing it to reach price parity with conventional meat within the next five years.

七十年前，丘吉尔（Churchill）著名地说：“我们将通过在合适的培养基中分别种植这些部分来逃避种植整只鸡以食用乳房或翅膀的荒谬性。”培养的肉是一种更健康的（较少的抗生素），更符合道德（更好的动物福利），更有效的效率（更好地利用土地）和可持续的生产肉类并满足人口增长的蛋白质需求。据估计，培养肉类的市场在2030年（麦肯锡）达到30B英镑。为了扩展生产过程，需要启用技术，例如可食用的微载体，这些微载体允许干细胞的锚固，增殖和分化，然后收集最终产品。 Naturbeads纤维素珠的生产过程（目前从飞行员到演示植物的扩展）允许自定义纤维素珠的性质，以促进细胞的附着，生长和分化。我们已经开发了一个原型，该原型显示了细胞培养板（2D）的性能（2D）优于市售脚手架，该脚手架目前仅在研发中仅用于研发，因为它们的成本被禁止。通过这个项目，我们旨在从概念验证到商业原型，我们可以在工业研发项目结束时出售，以锁定客户以扩大生产。 Naturbeads will work together with Cellular Agriculture to test the performance of the cellulose microcarriers in bioreactors (3D) to optimize the parameters for cell proliferation, Differentiation in developed tanks, and cell detachment.Naturbeads carriers are made of cellulose a natural, edible, and biocompatible biopolymer, that can be sourced sustainably from forestry groups part of PEFC (Programme for the endorsement of Forest 认证）。它也很便宜，提供了低成本的脚手架结构，有可能降低培养肉类的生产成本，从而使其在未来五年内与常规肉类达到价格均等。