Brain-based Mechanisms of Emotion Regulation in Aging and Mood Disorders

衰老和情绪障碍中基于大脑的情绪调节机制

基本信息

批准号：
10319173
负责人：
Katherine Elizabeth Burdick
金额：
$ 82.12万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-15 至 2025-10-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10319173
关键词：
Address Adult Affect Affective Age Aging Amygdaloid structure Attention Attenuated Base of the Brain Behavior Biological Biological Assay Bipolar Disorder Brain Clinical Cognition Cognitive Cognitive deficits Complex Coping Skills Depressive disorder Development Diagnostic Disease remission Elderly Emotional Emotions Enrollment Goals Impairment Intervention Learning Longevity Maintenance Major Depressive Disorder Maps Measures Mediating Memory Mental Depression Mental disorders Mood Disorders Moods National Institute of Mental Health Negative Valence Onset of illness Outcome Patient Self-Report Patients Pattern Performance Personal Satisfaction Play Process Recurrence Relapse Reporting Research Domain Criteria Rest Risk Role Sampling Services Social Functioning Stimulus Strategic Planning Structure Thinking Well in self Work age related aging brain attentional bias base clinically relevant cognitive control critical period emotion regulation emotional experience executive function flexibility functional disability heuristics improved middle age negative affect network dysfunction novel sex social social deficits therapy design therapy resistant trait white matter change

项目摘要

PROJECT SUMMARY Effective emotion regulation (ER) requires the ability to flexibly and dynamically respond to affectively-valenced stimuli in the service of goal-directed behaviors. Patients with major mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD) are characterized by brain-based abnormalities in affective processing and cognitive deficits that make it difficult for them to regulate their emotions. Disruptions in ER are thought to play a role in risk for onset of illness, a relapsing course, and incomplete remission. Aging may amplify poor outcomes in older adults with depression, as reflected in a more severe course and treatment resistance. In contrast, in healthy adults, ER improves across the lifespan with a shift from attending to negative to attending to positive stimuli in attention, learning and memory. Consistent with RDoC, we will leverage multiple units of analysis (circuit, performance, self-report) in a transdiagnostic sample enriched for a range of ER-related network functions, implicit attentional biases, and ER strategies. We will enroll 200 adults (ages 41-80) with an affectively-stable mood disorder (100 BD, 100 MDD), and 100 demographically-matched healthy controls, allowing us to capture the range from extreme positive to extreme negative emotional experience. We will assess performance-based affective biases, cognitive control, and resting-state functional connectivity (FC), to define age-related changes in ER circuitry. We will assay habitual use of ER strategies, social functioning, and well-being to determine how brain-based processes affect these functionally- and clinically-relevant outcomes. Impact. The goals of this project are directly aligned with the NIMH Strategic Plan to develop new ways of characterizing and treating mental illness that are predicated on understanding brain-based mechanisms. Beyond the heuristic value of understanding the specific mechanisms and developmental trajectory of ER in mid and late life, results can be used to inform the development of novel interventions (e.g., neurostimulation, cognitive interventions) designed to “rescue” the specific network dysfunctions that give rise to maladaptive ER in depressive disorders.

项目摘要有效的情绪调节（ER）需要能够灵活，动态地响应情感上的能力为目标指导行为提供刺激。患有主要情绪障碍的患者，包括躁郁症（BD）和主要抑郁症（MDD）的特征是情感中基于大脑的异常处理和认知定义了使他们难以调节情绪的困难。 ER中的干扰是想想在疾病发作，中继课程和不完全缓解的风险中发挥作用。衰老可能会放大抑郁症的老年人的结局不佳，这反映在更严重的病程和治疗耐药性中。在对比，在健康的成年人中，ER在整个生命周期中都改善了注意力，学习和记忆的积极刺激。与RDOC一致，我们将利用多个分析单位（电路，性能，自我报告）转诊样品丰富了一系列与ER相关的网络函数，隐式注意力偏见和ER 策略。我们将招募200名成年人（41-80岁），患有更稳定的情绪障碍（100 BD，100 MDD），和100个人口统计学匹配的健康对照，使我们能够捕获从极端正到的范围极端的负面情绪体验。我们将评估基于绩效的情感偏见，认知控制，以及静止状态功能连接性（FC），以定义与年龄相关的ER电路变化。我们将分析习惯使用ER策略，社会功能和福祉，以确定基于大脑的过程如何影响这些在功能和临床上的结果。影响。该项目的目标与NIMH战略计划直接保持一致，以制定新的方式表征和治疗精神疾病，这些精神疾病预测了基于大脑的机制。除了了解中期的ER的特定机制和发展轨迹的启发式价值之外和后期的生活，结果可用于告知新干预措施的发展（例如，神经刺激，认知干预措施）旨在“挽救”引起不良适应性ER的特定网络功能障碍抑郁症。