Oral Microbiome: Beyond Bacteria

口腔微生物组：超越细菌

基本信息

批准号：
10318787
负责人：
Xuesong He
金额：
$ 0.9万
依托单位：
ADA FORSYTH INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2022-06-30
项目状态：
已结题

项目摘要

This R13 proposal seeks support for Forsyth Symposium 2021 “Oral Microbiome: Beyond Bacteria” at the Forsyth Institute on October 28-29, 2021. The overall objective of the symposium is to promote better understanding of oral microbiome from a holistic perspective. Oral microbiome is composed of diverse bacterial species, fungal and viral (bacteriophage) components, as well as recently identified nano-sized parasitic Candidate Phyla Radiation (CPR) organisms. Effective management of oral microbiome-related diseases calls for a more comprehensive understanding of the impact of the oral microbiota on host health and disease, which requires a holistic view of intra- and cross-kingdom interactions among different members of the oral microbiome (including bacteria, fungi, phages and CPR organisms), as well as microbial-host interaction. The symposium will bring together a group of scientists with diverse research backgrounds in oral microbiome (including oral bacsteriome, mycobiome, phageome and CPR) and different career stages to share their research and ideas. The Symposium will include poster presentations by attendees and talks by: Ann Griffen, Matthew M. Ramsey, Hyun (Michel) Koo, Jill Banfield, Mircea Podar, Jeff McLean, Xuesong He, Kathryn Kauffman, David Moyes, Mahmoud Ghannoum, Patricia Diaz, Jessica Mark Welch, Yang-Yu Liu, and Anna Edlund. Another key objective is to identify biological questions and technical roadblocks that must be overcome to achieve a more comprehensive understanding of the impact of the oral microbiota on host health and disease from a holistic point of view. Meanwhile, the symposium will promote new collaborative researches which will expand from bacterial interspecies interactions to inter-kingdom interactions which include bacteria, CPR, fungi, and phages. It will also provide a great opportunity for trainees to interact with experts in the field and promote their research. More importantly, by encouraging female trainees and trainees with disabilities or of minority groups, the symposium aims to promote the engagement of underrepresented groups in dental research. The conference will create a community of investigators who have previously resided in scientific silos that did not meet or communicate with each other: oral bacteriome, mycobiome, phageome and CPR. These investigators will now communicate and hopefully develop collaborative research to achieve a fundamental understanding of oral microbiome from a holistic perspective, which will ultimately improve our ability to diagnose and treat microbial infections.

该R13提案寻求支持2021年Forsyth研讨会“口服微生物组：超越细菌” 福赛斯研究所（Forsyth Institute）于2021年10月28日至29日。专题讨论会的总体目标是更好地促进从整体的角度了解口服微生物组。口服微生物组由潜水员组成细菌种，真菌和病毒（噬菌体）成分，以及最近确定的纳米大小寄生虫门辐射（CPR）生物。与口服微生物组相关的有效管理疾病要求对口腔微生物群对宿主健康的影响有更全面的了解和疾病，这需要对不同成员之间的内部和跨王国相互作用的整体视野口服微生物组（包括细菌，真菌，噬菌体和CPR生物）以及微生物宿主相互作用。研讨会将汇集一群具有口头领域潜水员研究背景的科学家微生物组（包括口腔bacsteriome，mycobiome，Phageome和CPR）以及不同的职业阶段分享他们的研究和想法。研讨会将包括与会者的海报演讲，并通过： Ann Griffen，Matthew M. Ramsey，Hyun（Michel）Koo，Jill Banfield，Mircea Podar，Jeff McLean，Xuesong He， Kathryn Kauffman，David Moyes，Mahmoud Ghannoum，Patricia Diaz，Jessica Mark Welch，Yang-Yu Liu和安娜·埃德隆德（Anna Edlund）。另一个主要目标是确定必须是的生物学问题和技术障碍克服对口腔微生物群对宿主健康的影响的更全面的了解从整体的角度来看。意思是，研讨会将促进新的合作将从细菌的种间相互作用到昆神之间的相互作用的研究包括细菌，CPR，真菌和噬菌体。这也将为学员互动提供一个绝佳的机会该领域的专家并促进他们的研究。更重要的是，通过鼓励女学员和疾病或少数群体的学员，旨在促进参与牙科研究中代表性不足的群体。会议将创建一个调查员社区以前一直呆在没有相遇或交流的科学孤岛中：口服细菌群，， Mycobiome，Phageome和CPR。这些调查人员现在将进行交流并希望发展合作研究以从整体的角度来实现对口腔微生物组的基本理解，最终将提高我们诊断和治疗微生物感染的能力。