Oral Microbiome: Beyond Bacteria

口腔微生物组：超越细菌

基本信息

批准号：
10318787
负责人：
Xuesong He
金额：
$ 0.9万
依托单位：
ADA FORSYTH INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2022-06-30
项目状态：
已结题

项目摘要

This R13 proposal seeks support for Forsyth Symposium 2021 “Oral Microbiome: Beyond Bacteria” at the Forsyth Institute on October 28-29, 2021. The overall objective of the symposium is to promote better understanding of oral microbiome from a holistic perspective. Oral microbiome is composed of diverse bacterial species, fungal and viral (bacteriophage) components, as well as recently identified nano-sized parasitic Candidate Phyla Radiation (CPR) organisms. Effective management of oral microbiome-related diseases calls for a more comprehensive understanding of the impact of the oral microbiota on host health and disease, which requires a holistic view of intra- and cross-kingdom interactions among different members of the oral microbiome (including bacteria, fungi, phages and CPR organisms), as well as microbial-host interaction. The symposium will bring together a group of scientists with diverse research backgrounds in oral microbiome (including oral bacsteriome, mycobiome, phageome and CPR) and different career stages to share their research and ideas. The Symposium will include poster presentations by attendees and talks by: Ann Griffen, Matthew M. Ramsey, Hyun (Michel) Koo, Jill Banfield, Mircea Podar, Jeff McLean, Xuesong He, Kathryn Kauffman, David Moyes, Mahmoud Ghannoum, Patricia Diaz, Jessica Mark Welch, Yang-Yu Liu, and Anna Edlund. Another key objective is to identify biological questions and technical roadblocks that must be overcome to achieve a more comprehensive understanding of the impact of the oral microbiota on host health and disease from a holistic point of view. Meanwhile, the symposium will promote new collaborative researches which will expand from bacterial interspecies interactions to inter-kingdom interactions which include bacteria, CPR, fungi, and phages. It will also provide a great opportunity for trainees to interact with experts in the field and promote their research. More importantly, by encouraging female trainees and trainees with disabilities or of minority groups, the symposium aims to promote the engagement of underrepresented groups in dental research. The conference will create a community of investigators who have previously resided in scientific silos that did not meet or communicate with each other: oral bacteriome, mycobiome, phageome and CPR. These investigators will now communicate and hopefully develop collaborative research to achieve a fundamental understanding of oral microbiome from a holistic perspective, which will ultimately improve our ability to diagnose and treat microbial infections.

该 R13 提案寻求对 2021 年福赛思研讨会“口腔微生物组：超越细菌”的支持福赛斯研究所于2021年10月28-29日举行。研讨会的总体目标是促进更好的从整体角度理解口腔微生物组由多种组成。物种细菌、真菌和病毒（噬菌体）成分，以及最近发现的纳米尺寸寄生候选门辐射（CPR）生物体的口腔微生物组相关的有效管理。疾病需要更全面地了解口腔微生物群对宿主健康的影响和疾病，这需要对不同成员之间的内部和跨王国相互作用有一个整体的看法口腔微生物群（包括细菌、真菌、噬菌体和 CPR 生物体）以及微生物宿主研讨会将汇集一群具有不同口语研究背景的科学家。微生物组（包括口腔细菌组、真菌组、噬菌体组和心肺复苏）和不同的职业阶段研讨会将包括与会者的海报展示和以下人员的演讲：安·格里芬、马修·拉姆齐、Hyun (Michel) Koo、吉尔·班菲尔德、米尔恰·波达尔、杰夫·麦克莱恩、何雪松、凯瑟琳·考夫曼、大卫·莫耶斯、马哈茂德·加努姆、帕特里夏·迪亚兹、杰西卡·马克·韦尔奇、刘阳宇和安娜·埃德伦德（Anna Edlund）的另一个关键目标是确定必须解决的生物学问题和技术障碍。克服困难，更全面地了解口腔微生物群对宿主健康的影响同时，研讨会将促进新的合作。研究将从细菌种间相互作用扩展到王国间相互作用包括细菌、心肺复苏、真菌和噬菌体，这也将为学员提供一个很好的互动机会。更重要的是，通过鼓励女性学员和该领域的专家来促进他们的研究。研讨会旨在促进残疾或少数群体学员的参与该会议将创建一个由牙科研究领域代表性不足的群体组成的研究人员社区。以前居住在彼此不见面或交流的科学孤岛中：口腔细菌组，这些研究人员现在将进行交流并有望发展。合作研究，从整体角度对口腔微生物组有基本的了解，这最终将提高我们诊断和治疗微生物感染的能力。